Gangrene: Types and Pathogenesis

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Questions and Answers

What is the common cause of gradual loss of arterial supply to an organ or tissue, leading to gangrene?

  • Atherosclerosis and trauma
  • Ergot poisoning and arteriosclerosis
  • Trauma and ergot poisoning
  • All of the above (correct)

Which type of gangrene is characterized by severe bacterial infection superimposed on necrosis?

  • Coagulative necrosis
  • Caseous necrosis
  • Dry gangrene
  • Wet gangrene (correct)

What is the characteristic feature of caseous necrosis?

  • Edema and foul smell
  • White, cheese-like, friable foci of necrosis (correct)
  • Coagulative necrosis with preserved tissue architecture
  • Blackening of tissue due to iron sulfide formation

What is the term used to describe the inflammatory border surrounding caseous necrosis?

<p>Granuloma (C)</p> Signup and view all the answers

What is the characteristic feature of an infarct?

<p>Localized area of coagulative necrosis (A)</p> Signup and view all the answers

What is the term used to describe tissue architecture preservation with intense eosinophilia and loss of nuclear details?

<p>Acidophilic tombstone (C)</p> Signup and view all the answers

What does the 'T' component of the TNM staging system represent?

<p>Primary tumor (A)</p> Signup and view all the answers

What is the term for permanent changes in the DNA?

<p>Mutation (C)</p> Signup and view all the answers

How many genes do humans have that can be involved in changes to their structure, causing diseases?

<p>30,000 genes (B)</p> Signup and view all the answers

What percentage of undifferentiated cells corresponds to Grade IV according to Brooder's classification?

<p>0-25% (C)</p> Signup and view all the answers

What type of mutation involves the substitution of a single nucleotide base, resulting in the replacement of a single amino acid in a protein molecule?

<p>Point mutation (C)</p> Signup and view all the answers

Which stage of cancer has the characteristics of a small and localized tumor confined to one location?

<p>Stage 1 (A)</p> Signup and view all the answers

What is the term for the spread of cancer cells to other areas and establishment of new tumors in different organs?

<p>Metastasis (C)</p> Signup and view all the answers

What is the term for a genetic disorder resulting from mutations in single genes?

<p>Mendelian disorder (B)</p> Signup and view all the answers

What is the term for genetic disorders involving multiple genes as well as environmental influences?

<p>Complex disorder (B)</p> Signup and view all the answers

According to SEER Scales, which stage of cancer has the characteristics of cancer cells detectable in the surrounding lymph nodes?

<p>Stage 3 (C)</p> Signup and view all the answers

What is the term for cancer that is not yet fully defined and has an unknown number of staging?

<p>Not yet fully defined (C)</p> Signup and view all the answers

According to Brooder's classification, what percentage of differentiated cells corresponds to Grade I?

<p>75-100% (A)</p> Signup and view all the answers

What is the characteristic color of congested tissues?

<p>Abnormal blue-red (D)</p> Signup and view all the answers

Which of the following syndromes is characterized by a single palmar crease?

<p>Edward's Syndrome (B)</p> Signup and view all the answers

What is the primary cause of Edward's Syndrome?

<p>Trisomy 18 (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of Cri du Chat Syndrome?

<p>Cleft lip and palate (D)</p> Signup and view all the answers

What is the characteristic facial feature of Cri du Chat Syndrome?

<p>Round face, hypertelorism (C)</p> Signup and view all the answers

Which of the following syndromes is characterized by polydactyly?

<p>Patau's Syndrome (B)</p> Signup and view all the answers

What is a key consideration when selecting tissue for sectioning?

<p>The tissue should be thin enough to allow penetration by fixative within a reasonable amount of time (C)</p> Signup and view all the answers

What is the primary reason for fixing the brain tissue before grossing or sectioning?

<p>It is generally soft when unfixed (C)</p> Signup and view all the answers

What is a consequence of prolonged fixation?

<p>Loss of immunohistochemical antigenicity (D)</p> Signup and view all the answers

What is the effect of refrigeration on tissue decomposition?

<p>It slows down decomposition (A)</p> Signup and view all the answers

What is one of the benefits of using fixative on tissue?

<p>It makes cells resistant to damage and distortion by hypertonic and hypotonic solutions (A)</p> Signup and view all the answers

What is a unique characteristic of bone marrow compared to brain cells?

<p>It continues to undergo mitosis up to 30 minutes if refrigerated (A)</p> Signup and view all the answers

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