Fungal Infections in Pharmacy
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Questions and Answers

What is the primary mechanism of action of butenafine, naftifine, and terbinafine?

  • Disruption of the fungal mitotic spindle
  • Inhibition of fungal cell wall synthesis
  • Disruption of the fungal cell membrane
  • Inhibition of squalene epoxidase (correct)
  • Which of the following is the drug of choice for treating dermatophyte onychomycosis (fungal nail infections)?

  • Amphotericin B
  • Terbinafine (correct)
  • Itraconazole
  • Griseofulvin
  • Which of the following is true regarding the use of topical antifungals for tinea capitis (scalp infection)?

  • Topical antifungals can be used in combination with oral antifungals for tinea capitis
  • Topical antifungals are ineffective for tinea capitis, oral antifungals are needed (correct)
  • Topical antifungals are as effective as oral antifungals for tinea capitis
  • Topical antifungals are the preferred treatment for tinea capitis
  • Which of the following adverse effects is commonly associated with terbinafine?

    <p>Gastrointestinal distress</p> Signup and view all the answers

    How does the absorption of griseofulvin from the gastrointestinal tract differ from other oral antifungal medications?

    <p>Griseofulvin absorption is enhanced by high-fat meals</p> Signup and view all the answers

    What is the primary mechanism of action of griseofulvin as an antifungal agent?

    <p>Disruption of the fungal mitotic spindle</p> Signup and view all the answers

    What is the mechanism of action of echinocandins like caspofungin, micafungin, and anidulafungin?

    <p>Inhibiting fungal cell wall synthesis by blocking (1,3)-D-glucan</p> Signup and view all the answers

    Which of the following statements about fluconazole is correct?

    <p>It has the least effect on the CYP450 enzyme system.</p> Signup and view all the answers

    Which of the following is a common adverse effect associated with echinocandins like caspofungin, micafungin, and anidulafungin?

    <p>Phlebitis at the infusion site</p> Signup and view all the answers

    Which class of antifungal agents acts as antimetabolites?

    <p>Squalene epoxidase inhibitors</p> Signup and view all the answers

    Amphotericin B is a member of which class of antifungal agents?

    <p>Polyene antifungals</p> Signup and view all the answers

    What is the mechanism of action of amphotericin B?

    <p>It binds to ergosterol in the fungal cell membrane and forms pores, leading to cell death.</p> Signup and view all the answers

    How is amphotericin B typically administered?

    <p>Intravenously as a lipid formulation, as it is insoluble in water.</p> Signup and view all the answers

    Which of the following is a common adverse effect of amphotericin B?

    <p>Renal damage</p> Signup and view all the answers

    What is the mechanism of action of flucytosine?

    <p>It is converted to 5-fluorouracil, which inhibits thymidylate synthase and DNA synthesis.</p> Signup and view all the answers

    Which of the following statements about flucytosine is true?

    <p>It is often used in combination with other antifungal drugs due to its narrow spectrum.</p> Signup and view all the answers

    What is the primary mechanism of action of azole antifungals?

    <p>They inhibit the 14-demethylase enzyme, blocking ergosterol biosynthesis in fungi.</p> Signup and view all the answers

    Which of the following is a common adverse effect associated with azole antifungals?

    <p>Gastrointestinal upset</p> Signup and view all the answers

    Which statement about the pharmacokinetics of amphotericin B is true?

    <p>Inflammation favors its penetration into various body fluids, except CSF.</p> Signup and view all the answers

    Which of the following statements about azole antifungals is true?

    <p>They have a high incidence of drug interactions due to their inhibition of the CYP3A4 enzyme.</p> Signup and view all the answers

    Which of the following statements about amphotericin B is false?

    <p>It is well absorbed from the gastrointestinal tract.</p> Signup and view all the answers

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