COPY: Functions and Types of Immune System
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Questions and Answers

Which type of immunity is present in all normal individuals?

  • Innate immunity (correct)
  • Active immunity
  • Passive immunity
  • Acquired immunity
  • What are the components of innate resistance?

  • Hormones, neurotransmitters, enzymes, and antigens
  • Physical barriers, phagocytic cells, proteins, and presence of normal flora (correct)
  • Antibodies, T cells, B cells, and cytokines
  • Pathogens, antigens, toxins, and allergens
  • Which major activity involves the immune system's ability to remember past infections?

  • Response
  • Elimination
  • Recognition
  • Memory (correct)
  • What does innate immunity discriminate among?

    <p>It doesn't discriminate amongst microorganisms of different species</p> Signup and view all the answers

    Which type of immunity is acquired through clinical or subclinical infection?

    <p>Active immunity</p> Signup and view all the answers

    What regulates innate immunity?

    <p>Physiological conditions such as nutrition, age, hormones, etc.</p> Signup and view all the answers

    Which cells are involved in innate resistance as phagocytic cells?

    <p>Neutrophils, Macrophages and Natural Killer cells</p> Signup and view all the answers

    What type of immunization involves exposure to microbial products like toxins?

    <p>Exposure to toxins and toxoids</p> Signup and view all the answers

    Which type of immunity does not alter in intensity upon reexposure?

    <p>Innate immunity</p> Signup and view all the answers

    Which of the following is NOT a characteristic of innate immunity?

    <p>It is selective</p> Signup and view all the answers

    Which of the following components is NOT part of innate resistance?

    <p>T cells</p> Signup and view all the answers

    What type of immunity involves immunization with live or killed infectious agents or their antigens?

    <p>Acquired immunity</p> Signup and view all the answers

    Which physiological conditions regulate innate immunity?

    <p>All of the above</p> Signup and view all the answers

    Which major activity of the immune response involves the ability to recognize pathogens?

    <p>Recognition</p> Signup and view all the answers

    Which type of immunity is regulated by physiological conditions such as nutrition, age, and hormones?

    <p>Innate immunity</p> Signup and view all the answers

    What type of immunity is present in all normal individuals?

    <p>Innate immunity</p> Signup and view all the answers

    What is the function of phagocytic cells in innate resistance?

    <p>They engulf and digest pathogens</p> Signup and view all the answers

    Which component provides competitive inhibition as part of innate resistance?

    <p>Normal flora</p> Signup and view all the answers

    Which antibody is the most abundant class in serum?

    <p>IgG</p> Signup and view all the answers

    What is the molecular weight of IgM?

    <p>900,000</p> Signup and view all the answers

    Which antibody is the predominant antibody in secondary response?

    <p>IgG</p> Signup and view all the answers

    In which secretions is IgA the major Ig?

    <p>Respiratory, Intestinal &amp; Genital tract secretions</p> Signup and view all the answers

    Which antibody exists mainly as a monomer in serum but can occur in polymeric forms?

    <p>IgA</p> Signup and view all the answers

    Which antibody is the first Ig in the primary response and is synthesized by neonates?

    <p>IgM</p> Signup and view all the answers

    Which antibody opsonizes/activates complement and is the only one to cross the placenta?

    <p>IgG</p> Signup and view all the answers

    What are the effector molecules of humoral immunity and are present in the serum?

    <p>Antibodies</p> Signup and view all the answers

    Which antibody primarily functions as a B-Cell receptor and may participate in B-Cell maturation, maintenance, and activation?

    <p>IgD</p> Signup and view all the answers

    Which Ig constitutes approximately 15% of total Ig in serum and is a major Ig in secretions such as colostrum, saliva, and tears?

    <p>IgA</p> Signup and view all the answers

    Which antibody is important in host defense against helminth or worm infections?

    <p>IgE</p> Signup and view all the answers

    Which antibody has the Fc portion that binds to the surface of mast cells and basophils, mediating immediate hypersensitive reactions?

    <p>IgE</p> Signup and view all the answers

    What is the mechanism of action of Polyenes such as Amphotericin B?

    <p>Formation of a complex with Ergosterol leading to cytoplasmic leakage</p> Signup and view all the answers

    Which enzyme do Azoles inhibit to cause depletion of ergosterol in the fungal cell membrane?

    <p>Cytochrome p450 3A-dependent C14demethylase</p> Signup and view all the answers

    What is the primary mechanism of action of Glucan synthesis Inhibitors like Caspofungin and Micafungin?

    <p>Inhibition of 1,3 D-glucan synthase</p> Signup and view all the answers

    How do Allylamines act as anti-fungal agents?

    <p>Inhibition of ergosterol synthesis by inhibiting squalene oxidase</p> Signup and view all the answers

    How does Griseofulvin act to prevent fungal cell division?

    <p>Disruption of fungal cell mitotic spindles</p> Signup and view all the answers

    What is the MOA of Polyenes such as Amphotericin B?

    <p>Formation of a complex with Ergosterol leading to cytoplasmic leakage</p> Signup and view all the answers

    Which anti-fungal agent primarily acts by inhibiting the fungal cytochrome p450 3A –dependent C 14demethylase?

    <p>Flucytosine</p> Signup and view all the answers

    How do Azoles such as Clotrimazole and Fluconazole act as anti-fungal agents?

    <p>Inhibiting ergosterol synthesis</p> Signup and view all the answers

    Which anti-fungal agent inhibits fungal cell wall synthesis by inhibiting 1,3 D-glucan synthase?

    <p>Caspofungin</p> Signup and view all the answers

    What is the primary mode of action of Allylamines like Terbinafine?

    <p>Inhibition of ergosterol synthesis</p> Signup and view all the answers

    What is the mechanism of action of Griseofulvin as an anti-fungal agent?

    <p>Disruption of fungal cell mitotic spindles</p> Signup and view all the answers

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