10 Questions
Which of the following is a component of the tetrahydrofolate molecule (THF)?
Pteridine portion
What is the role of folic acid in protein synthesis?
Participates in formylation of transference RNAs
Why is folic acid supplementation particularly important during pregnancy?
Essential for nucleic acid synthesis
Which metabolic function highlights the importance of antifolates?
Essential for cell survival
In which biosynthetic pathways does folate participate?
Protein and nucleic acid synthesis
Which of the following is NOT a component of the tetrahydrofolate molecule (THF)?
Riboflavin
What is the role of folic acid in protein synthesis?
Formylation of transference RNAs
Why is folic acid supplementation important during pregnancy?
Promotes fetal brain development
In which biosynthetic pathway does folate participate?
Nucleic acid synthesis
What are antifolates known for?
Inhibiting folic acid metabolism
Study Notes
Tetrahydrofolate Molecule (THF)
- A component of THF is p-aminobenzoic acid (PABA)
Folic Acid in Protein Synthesis
- Folic acid is essential for one-carbon metabolism, allowing for the synthesis of amino acids, such as methionine and serine
- Folic acid is necessary for the transfer of one-carbon units in amino acid synthesis
Folic Acid Supplementation in Pregnancy
- Folic acid supplementation during pregnancy helps prevent neural tube defects in the fetus
- Supplementation is critical, as the demand for folate increases during fetal development
Antifolates and Metabolic Function
- Antifolates, such as methotrexate, inhibit the action of folic acid, highlighting the importance of folic acid in cell growth and proliferation
- Antifolates are used to treat cancer, as they inhibit the rapid cell division characteristic of cancer cells
Biosynthetic Pathways
- Folate participates in the synthesis of methionine, serine, and glycine
- Folate is essential for the interconversion of amino acids, such as homocysteine and methionine
Antifolates
- Antifolates are known for their ability to inhibit cell growth and proliferation by blocking the action of folic acid
Test your knowledge of folic acid metabolism, an essential process for the functioning of all living cells. Explore the role of folic acid in diverse metabolic functions and its composition as tetrahydrofolate molecule (THF).
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