Fluticasone and Salmeterol Overview

Questions and Answers

What are some brand names for Fluticasone/Salmeterol?

AirDuo RespiClick (correct)

Advair HFA (correct)

Relvar Ellipta

Advair Diskus (correct)

What is the drug class for Fluticasone/Salmeterol?

Inhaled corticosteroid, long-acting beta2 agonist

What are the indications for Fluticasone/Salmeterol?

Asthma, COPD

What is the mechanism of action of Fluticasone?

Anti-inflammatory activity, immunosuppressive properties and anti-proliferation properties Signup and view all the answers

How does Salmeterol work?

Relaxes bronchial smooth muscle by selective action on beta 2 receptors with little effect on heart rate Signup and view all the answers

What are the contraindications for Fluticasone/Salmeterol?

Status asthmaticus, acute episodes of asthma or COPD, hypersensitivity to milk proteins Signup and view all the answers

What is the Black Box warning for Fluticasone/Salmeterol?

Long-acting beta agonists/inhaled corticosteroid safety alert Signup and view all the answers

What are common adverse reactions to Fluticasone/Salmeterol?

Upper respiratory tract infection, pneumonia, pharyngitis Signup and view all the answers

What formulations are available for Fluticasone/Salmeterol?

Aerosol, powder Signup and view all the answers

Study Notes

Fluticasone/Salmeterol Overview

Commonly marketed as Advair Diskus, Advair HFA, and AirDuo RespiClick.
Combines an inhaled corticosteroid with a long-acting beta2 agonist.

Drug Classification

Categorized as an inhaled corticosteroid and long-acting beta2 agonist.

Indications for Use

Approved for the management of asthma and Chronic Obstructive Pulmonary Disease (COPD).

Mechanism of Action (Fluticasone)

Exhibits anti-inflammatory activity.
Possesses immunosuppressive properties and inhibits cellular proliferation.

Mechanism of Action (Salmeterol)

Relaxes bronchial smooth muscle through selective action on beta2 receptors, minimally affecting the heart rate.

Contraindications

Not recommended for the treatment of status asthmaticus or acute exacerbations of asthma or COPD.
Contraindicated in patients with a hypersensitivity to milk proteins.

Black Box Warning

Contains a safety alert regarding the use of long-acting beta agonists in combination with inhaled corticosteroids, indicating potential risks.

Adverse Reactions

Possible side effects include upper respiratory tract infections, pneumonia, and pharyngitis.

Formulations Available

Available in aerosol and powder forms for inhalation.

Description

This quiz covers the pharmacology of Fluticasone and Salmeterol, including their classifications and mechanisms of action. Learn about their approved uses for asthma and COPD management and essential safety information such as contraindications and black box warnings.