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Questions and Answers
Which of the following are brand names of Fluticasone/Salmeterol?
Which of the following are brand names of Fluticasone/Salmeterol?
What are the common FDA indications for Fluticasone/Salmeterol?
What are the common FDA indications for Fluticasone/Salmeterol?
What is the drug class of Fluticasone/Salmeterol?
What is the drug class of Fluticasone/Salmeterol?
Inhaled Corticosteroid and Long-Acting β2-Adrenergic Agonist Combination
What is the mechanism of action (MOA) of Fluticasone/Salmeterol?
What is the mechanism of action (MOA) of Fluticasone/Salmeterol?
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Renal dosing adjustment is required for Fluticasone/Salmeterol.
Renal dosing adjustment is required for Fluticasone/Salmeterol.
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Which of the following are available dosage forms for Fluticasone/Salmeterol?
Which of the following are available dosage forms for Fluticasone/Salmeterol?
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What is the dosing for asthma treatment with Fluticasone/Salmeterol?
What is the dosing for asthma treatment with Fluticasone/Salmeterol?
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What are some common adverse drug reactions (ADRs) associated with Fluticasone/Salmeterol?
What are some common adverse drug reactions (ADRs) associated with Fluticasone/Salmeterol?
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What are serious adverse drug reactions (ADRs) associated with Fluticasone/Salmeterol?
What are serious adverse drug reactions (ADRs) associated with Fluticasone/Salmeterol?
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What should be monitored in patients using Fluticasone/Salmeterol?
What should be monitored in patients using Fluticasone/Salmeterol?
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What is an important counseling point for patients using Fluticasone/Salmeterol?
What is an important counseling point for patients using Fluticasone/Salmeterol?
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What type of drug interactions should be considered with Fluticasone/Salmeterol?
What type of drug interactions should be considered with Fluticasone/Salmeterol?
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Fluticasone/Salmeterol should not be used as primary treatment for status asthmaticus.
Fluticasone/Salmeterol should not be used as primary treatment for status asthmaticus.
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There is a black box warning for increased asthma-related deaths with Fluticasone/Salmeterol.
There is a black box warning for increased asthma-related deaths with Fluticasone/Salmeterol.
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Study Notes
Brand Names
- Advair Diskus and Advair HFA are the brand names for Fluticasone/Salmeterol.
Common FDA Indications
- Approved for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Drug Class
- Classified as a combination of an Inhaled Corticosteroid and a Long-Acting β2-Adrenergic Agonist.
Mechanism of Action (MOA)
- Fluticasone functions as a synthetic corticosteroid with anti-inflammatory properties, acting as a human glucocorticoid receptor agonist that inhibits various cell types and mediators involved in asthma and COPD.
- Salmeterol, a long-acting β2-adrenergic agonist, stimulates adenylyl cyclase to convert ATP to cyclic AMP, resulting in bronchodilation and reduced mediator release from mast cells.
Renal Dosing Adjustment
- No renal dosing adjustment is required for use.
Available Dosage Forms
- Available as an aerosol powder for inhalation and metered dose inhaler (MDI).
Dosing Information
- For asthma, recommended dose is one disk or two MDI puffs every 12 hours, adjusted according to patient response.
- For COPD, recommended dose is one disk every 12 hours, also adjusted based on patient response.
Common Adverse Drug Reactions (ADRs)
- Frequently reported side effects include headache, pharyngitis, upper respiratory infection, and difficulty speaking.
- Less common side effects may include nausea, oral candidiasis, musculoskeletal pain, throat irritation, bronchitis, and dizziness.
Serious Adverse Drug Reactions
- Potential serious reactions include atrial fibrillation, myocardial infarction, anaphylaxis, osteoporosis, bronchospasm, exacerbation of asthma, and paradoxical bronchospasm.
Monitoring Parameters
- Monitor control of asthma or COPD symptoms, assessed through pulmonary function tests (PFTs).
- Assess for toxicity, focusing on bone mineral density and growth in children, routine ophthalmologic examinations, and signs of adrenal suppression or infection, including oral candidiasis.
Counseling Points
- Instruct on proper inhalation technique, advising to rinse the mouth with water post-use to prevent oral infections.
- Advise monitoring for toxicity signs like adrenal insufficiency and worsening pulmonary function.
Drug Interactions
- Be cautious with CYP3A4/5 inhibitors, as they may interact with Fluticasone/Salmeterol.
Contraindications
- Not to be used in cases of hypersensitivity to any component, including milk proteins.
- Should not be the primary treatment for status asthmaticus or acute episodes of asthma or COPD, and caution is advised with coadministration of posaconazole.
Black Box Warnings
- There is a risk of increased asthma-related deaths associated with this medication.
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Description
Test your knowledge with these flashcards on Fluticasone and Salmeterol. Learn about brand names, FDA indications, drug class, and the mechanism of action. Perfect for pharmacy students and healthcare professionals!
