Flavonoids Identification and Characterization

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Questions and Answers

What is the product of acid hydrolysis of Diosmin?

Diosmitin, glucose, and quercetin

Diosmitin, glucose, and rhamnose (correct)

Diosmitin, rhamnose, and rutinose

What is the chemical structure of Rutin?

5,7,3´,4´-tetrahydroxy flavanone-3-O-glucoside

5,7,3´,4´-tetrahydroxy flavanone-3-O-rutinoside

5,7,3´,4´-tetrahydroxy flavone-7-O-glucorhamnoside

5,7,3´,4´-tetrahydroxy flavonol-3-O-rutinoside (correct)

What is the pharmacological effect of Diosmin?

It is used to treat urinary tract infections

It is used to treat capillary fragility and hemorrhoidal disease

It is used to treat menorrhagia and varicose vein

It is used to treat all of the above (correct)

What is the classification of Diosmin?

Flavone glycoside Signup and view all the answers

What is the product of enzymatic hydrolysis of Rutin?

Quercetin, rutinose, and rhamnose Signup and view all the answers

What is the biochemical property of Rutin?

All of the above Signup and view all the answers

What is the source of Diosmin?

Barosma betulina leaves Signup and view all the answers

What is the brand name of Diosmin-containing tablets?

Diosed ®, Dioven® and Daflon' Signup and view all the answers

What is the general structure of flavonoids?

C-15 skeleton formed of two benzene rings Signup and view all the answers

What is the origin of one of the benzene rings in flavonoids?

Shikemic acid pathway only Signup and view all the answers

What is the effect of alkalies on flavonoids?

Flavonoids give a yellow color with alkalies Signup and view all the answers

What is the therapeutic use of flavonoids containing plants as buchu?

Diuretic Signup and view all the answers

What is the biochemical property of flavonoids?

Contain conjugated aromatic systems Signup and view all the answers

What is the effect of conc.H2SO4 on flavones and flavonols?

They give a yellow color with conc.H2SO4 Signup and view all the answers

What is the classification of flavonoids based on their structure?

O-glycosides and C-glycosides Signup and view all the answers

What is the pharmacological effect of isoflavone derivatives?

Estrogenic effect Signup and view all the answers

What is the result of the reaction between flavonoids and Wilson's reagent?

A bright yellow colour with yellowish green fluorescence Signup and view all the answers

What is the effect of aluminium chloride on flavonoids?

Formation of a yellow coloured complex Signup and view all the answers

What is the purpose of Shinoda's test?

To detect the presence of flavonoids Signup and view all the answers

What is the basic skeleton for all types and classes of flavonoids?

Flavon Signup and view all the answers

What is the result of the isomerization of flavanones?

Formation of chalcones which give orange to lemon colour Signup and view all the answers

What is the reaction between flavonoids and lead acetate?

Formation of a yellow coloured precipitate Signup and view all the answers

Study Notes

Flavonoids

Flavonoids are a large group of natural phenols derived from the parent substance flavone.
They are amongst the dye stuffs and water-soluble pigments of plant origin, often yellow pigments.
Flavonoids are derivatives of 1,3-diphenylpropane, with a C-15 skeleton formed of two benzene rings linked together by a pyran ring.

Structure and Classification

The basic skeleton for all types and classes of flavonoids is flavan.
Flavonoids are classified into different groups based on the presence or absence of OH- at C-3, ketone at C-4, and unsaturation between C-2 and C-3.

Identification and Characterization

Flavonoids give yellow coloured precipitate with lead acetate.
Flavonoids with free hydroxy group at C-5 react with boric acid and citric acid in anhydrous acetone to give a bright yellow colour with yellowish green fluorescence.
Flavonoids form a yellow coloured complex with 5% alcoholic AlCl3.
Alcoholic plant extract with Mg metal and conc. HCl gives red to violet or orange colour.

Occurrence and Uses

Flavonoids are abundant in many plant families such as Rutaceae, Leguminosae, Umbelliferae, and Compositae.
Flavonoids have various therapeutic uses, including as diuretics, antispasmodics, and antioxidants.

Flavone Glycosides

Apiin is a flavonoid found in parsley, used as an antispasmodic and diuretic.
Diosmin is a flavonoid found in Buchu leaves, used as a diuretic, urinary tract antiseptic, and in the treatment of peripheral vascular disorders.

Flavonol Glycosides

Rutin is a flavonol glycoside found in Ruta graveolens and Eucalyptus, used to treat capillary fragility, hemorrhage, bleeding gums, hemorrhoidal disease, menorrhagia, and varicose veins.

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Description

This quiz is about the identification and characterization of flavonoids, including their reactions with lead acetate, boric acid, and other reagents.