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Questions and Answers

What is the primary function of erythrocytes?

  • Responsible for the transport of nutrients
  • Responsible for immune response
  • Responsible for the transport of oxygen and carbon dioxide (correct)
  • Responsible for waste removal
  • Why do residents living at higher altitudes generally have more red blood cells?

  • Due to a decrease in red blood cell count
  • Due to an increase in platelet count
  • Due to adaptation to lower oxygen levels (correct)
  • Due to a decrease in white blood cell count
  • What is the average lifespan of human erythrocytes?

  • 120 days (correct)
  • 60 days
  • 90 days
  • 180 days
  • Which organ is responsible for destroying old red blood cells bearing specific sugar groups?

    <p>Spleen</p> Signup and view all the answers

    What structural adaptation of erythrocytes enhances their capability for gaseous exchange?

    <p>Biconcave disc-like shape</p> Signup and view all the answers

    What is the main function of haemoglobin in red blood cells?

    <p>Facilitate gaseous exchange</p> Signup and view all the answers

    Which proteins are part of the cytoskeleton network in red blood cells?

    <p>Spectrin, Actin, and Adducin</p> Signup and view all the answers

    What condition is caused by defects in cytoskeletal components of erythrocytes?

    <p>Hereditary spherocytosis</p> Signup and view all the answers

    What is the clinical consequence of hereditary spherocytosis on oxygen transport?

    <p>Less oxygen transport compared to normal erythrocytes</p> Signup and view all the answers

    Which ion channels are involved in ions transport in red blood cells?

    <p>Calcium-dependent potassium channels</p> Signup and view all the answers

    What controls the mitotic activity and differentiation of progenitor cells?

    <p>Specific hemopoietic factors</p> Signup and view all the answers

    Which cytokine is NOT involved in the control of erythropoiesis?

    <p>Interferon</p> Signup and view all the answers

    At what stage does Hb synthesis start during erythropoiesis?

    <p>Polychromatophilic erythroblasts</p> Signup and view all the answers

    Which stage in erythropoiesis results in the nucleus becoming eccentric for expulsion?

    <p>Orthochromatophilic erythroblast</p> Signup and view all the answers

    What is a distinguishing feature of reticulocytes?

    <p>They are spherical with remnants of ribosomes</p> Signup and view all the answers

    What is responsible for the MNS blood groups among transmembrane glycoproteins?

    <p>Glycophorin A</p> Signup and view all the answers

    Which specific carbohydrate chains on the red blood cell plasmalemma determine an individual's blood group?

    <p>Inherited carbohydrate chains</p> Signup and view all the answers

    What regulates the process of hemopoiesis during which stem cells differentiate into mature blood cells?

    <p>Growth factors and cytokines</p> Signup and view all the answers

    Which cells are responsible for the formation of various progenitor cells during hemopoiesis?

    <p>Pluripotent hemopoietic stem cells (PHSCs)</p> Signup and view all the answers

    What accounts for about 0.1% of the nucleated cell population of bone marrow and gives rise to two types of multipotential hemopoietic stem cells?

    <p>Pluripotent hemopoietic stem cells (PHSCs)</p> Signup and view all the answers

    What is the main role of haemoglobin in red blood cells?

    <p>Facilitating gaseous exchange</p> Signup and view all the answers

    Which component is responsible for maintaining the biconcave disk shape of erythrocytes?

    <p>Spectrin</p> Signup and view all the answers

    What clinical condition results from the synthesis of abnormal spectrin?

    <p>Hereditary spherocytosis</p> Signup and view all the answers

    Which ion channels are involved in ions transport in red blood cells, according to the text?

    <p>Calcium-dependent potassium channels and Na+-K+ ATPase</p> Signup and view all the answers

    What is the main reason for residents living at higher altitudes having more red blood cells?

    <p>Increased production of erythropoietin in response to low oxygen levels</p> Signup and view all the answers

    What is the significance of the biconcave disc-like shape of erythrocytes?

    <p>It allows for a greater amount of hemoglobin to be packed into the cell</p> Signup and view all the answers

    Why do erythrocytes expel all cell organelles and the nucleus during their development in the bone marrow?

    <p>To provide more space for hemoglobin within the cell</p> Signup and view all the answers

    What happens when red blood cells display a group of oligosaccharides on their surface?

    <p>They are destroyed by macrophages in the spleen, bone marrow, and liver</p> Signup and view all the answers

    How does the lack of a nucleus benefit mature erythrocytes in their function?

    <p>Provides more space for storing hemoglobin molecules</p> Signup and view all the answers

    Which stage of erythropoiesis is characterized by abundant ribosomes for hemoglobin synthesis?

    <p>Basophilic erythroblast</p> Signup and view all the answers

    What is the main physiological function of steel factor in erythropoiesis?

    <p>Promoting differentiation of hematopoietic stem cells into erythroid progenitor cells</p> Signup and view all the answers

    Which cytokine is involved in the control of erythropoiesis but is not specifically mentioned in the text?

    <p>Interleukin-7 (IL-7)</p> Signup and view all the answers

    What is the defining characteristic of a reticulocyte?

    <p>Presence of a nucleus</p> Signup and view all the answers

    During which stage of erythropoiesis does the nucleus become eccentric in preparation for expulsion?

    <p>Orthochromatophilic erythroblast</p> Signup and view all the answers

    Which cell population is responsible for the formation of various progenitor cells during hemopoiesis?

    <p>Multipotential hemopoietic stem cells (MHSCs)</p> Signup and view all the answers

    What role do specific inherited carbohydrate chains play in the red blood cell plasmalemma?

    <p>Acting as antigens and determining blood group</p> Signup and view all the answers

    What regulates the type of blood cells formed and their rate of formation during hemopoiesis?

    <p>Growth factors</p> Signup and view all the answers

    Which stage of cell development results in stem cells differentiating through several intermediate stages to give rise to mature blood cells?

    <p>Intermediate progenitor cell stage</p> Signup and view all the answers

    Which factor accounts for about 0.1% of the nucleated cell population of bone marrow and gives rise to two types of multipotential hemopoietic stem cells?

    <p>Pluripotential hemopoietic stem cells (PHSCs)</p> Signup and view all the answers

    What is the main function of hemoglobin in red blood cells?

    <p>Transporting oxygen from the lungs to tissues</p> Signup and view all the answers

    What is the significance of the hematocrit value in relation to red blood cells?

    <p>Measuring the percentage of red blood cells in whole blood</p> Signup and view all the answers

    Why do mature red blood cells lack a nucleus?

    <p>To increase their internal space for oxygen transport</p> Signup and view all the answers

    In which capillaries do red blood cells pick up oxygen and form oxyhemoglobin?

    <p>Pulmonary capillaries</p> Signup and view all the answers

    What is the normal range of red blood cell count in adults per microliter of blood?

    <p>$4.5$ to $5.5$ million cells</p> Signup and view all the answers

    What is the primary role of red blood cells in the body?

    <p>Transporting oxygen to tissues</p> Signup and view all the answers

    How does hemoglobin change when it reaches systemic capillaries?

    <p>It releases most of its oxygen and becomes reduced hemoglobin</p> Signup and view all the answers

    Why are mature red blood cells highly specialized for their oxygen transport function?

    <p>As they lack a nucleus, all internal space is available for oxygen transport</p> Signup and view all the answers

    What is responsible for the majority of erythropoietin production in the body?

    <p>Kidney</p> Signup and view all the answers

    Which hormone promotes tissue metabolism in general and is required for erythropoiesis?

    <p>Thyroxine</p> Signup and view all the answers

    In what organ does erythropoiesis primarily occur during embryonic life?

    <p>Liver</p> Signup and view all the answers

    What deficiency can result from the destruction of bone marrow by irradiation, chemicals, drugs, or bacterial toxins?

    <p>Aplastic anemia</p> Signup and view all the answers

    What factor stimulates the rate of red blood cell production in response to hypoxia?

    <p>Erythropoietin</p> Signup and view all the answers

    Which organ secretes a small amount of erythropoietin?

    <p>Kidneys</p> Signup and view all the answers

    When O2 transport to tissues exceeds normal levels, what happens to the production of erythropoietin?

    <p>Decreases</p> Signup and view all the answers

    Which factor is essential for the maturation of red blood cells, important for nuclear maturation and cell division of red cell precursors?

    <p>Vitamin B12</p> Signup and view all the answers

    What does a healthy liver manufacture and store that is essential for normal red blood cell formation?

    <p>Globin and iron</p> Signup and view all the answers

    What is the primary regulating factor for erythropoiesis in the body?

    <p>Oxygen levels</p> Signup and view all the answers

    What vitamins are essential for the maturation of red blood cells, aiding in nuclear maturation and cell division?

    <p>Vitamin B12 and folic acid</p> Signup and view all the answers

    Which substance is NOT necessary for the development and maturation of erythrocytes, according to the text?

    <p>Iron</p> Signup and view all the answers

    Which external source influences general metabolism, growth of body tissues including bone marrow, but is not specific to red blood cell formation?

    <p>Vitamin C</p> Signup and view all the answers

    Where does erythropoiesis primarily occur during postnatal and adult life?

    <p>Red bone marrow</p> Signup and view all the answers

    What type of food is the main source of Vitamin B12 according to the text?

    <p>&quot;Animal food&quot;</p> Signup and view all the answers

    Which hormone is responsible for stimulating the red bone marrow to increase red blood cell production?

    <p>Erythropoietin</p> Signup and view all the answers

    What is the primary function of the intrinsic factor produced by parietal cells in the stomach lining?

    <p>Promote absorption of vitamin B12</p> Signup and view all the answers

    What is the storage organ for absorbed vitamin B12 in the human body?

    <p>Liver</p> Signup and view all the answers

    Which nutrient is essential for the formation of the heme part of hemoglobin?

    <p>Iron</p> Signup and view all the answers

    What are the roles of copper and cobalt in hemoglobin synthesis?

    <p>Catalysts for hemoglobin synthesis</p> Signup and view all the answers

    What is the average hemoglobin concentration in blood for men according to the text?

    <p>$16 ext{ g/dl}$</p> Signup and view all the answers

    How many heme fractions are present in each hemoglobin molecule?

    <p>$4$</p> Signup and view all the answers

    What is the main function of hemoglobin in red blood cells according to the text?

    <p>$O_2$ and $CO_2$ transport</p> Signup and view all the answers

    Where are the majority of animal proteins that are superior in producing haemoglobin found?

    <p>Muscles</p> Signup and view all the answers

    What compound is formed by the combination of Hb with CO2?

    <p>Carbaminohaemoglobin</p> Signup and view all the answers

    Which derivative of Hb remains in the ferrous state?

    <p>Oxyhaemoglobin</p> Signup and view all the answers

    What occurs when blood is exposed to drugs causing the conversion of Fe++ to Fe+++?

    <p>Formation of Methaemoglobin</p> Signup and view all the answers

    Which compound has an affinity for CO that is 200 times more than its affinity for O2?

    <p>Methaemoglobin</p> Signup and view all the answers

    What is the primary characteristic of Methaemoglobin?

    <p>Contains Fe+++ instead of Fe++</p> Signup and view all the answers

    Which type of Hb results when O2 is released from oxyhaemoglobin?

    <p>Deoxyhaemoglobin</p> Signup and view all the answers

    What happens when Hb binds to carbon monoxide (CO)?

    <p>Production of Carboxyhaemoglobin</p> Signup and view all the answers

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