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Questions and Answers

What is the primary function of erythrocytes?

  • Responsible for the transport of nutrients
  • Responsible for immune response
  • Responsible for the transport of oxygen and carbon dioxide (correct)
  • Responsible for waste removal

Why do residents living at higher altitudes generally have more red blood cells?

  • Due to a decrease in red blood cell count
  • Due to an increase in platelet count
  • Due to adaptation to lower oxygen levels (correct)
  • Due to a decrease in white blood cell count

What is the average lifespan of human erythrocytes?

  • 120 days (correct)
  • 60 days
  • 90 days
  • 180 days

Which organ is responsible for destroying old red blood cells bearing specific sugar groups?

<p>Spleen (D)</p> Signup and view all the answers

What structural adaptation of erythrocytes enhances their capability for gaseous exchange?

<p>Biconcave disc-like shape (C)</p> Signup and view all the answers

What is the main function of haemoglobin in red blood cells?

<p>Facilitate gaseous exchange (C)</p> Signup and view all the answers

Which proteins are part of the cytoskeleton network in red blood cells?

<p>Spectrin, Actin, and Adducin (B)</p> Signup and view all the answers

What condition is caused by defects in cytoskeletal components of erythrocytes?

<p>Hereditary spherocytosis (B)</p> Signup and view all the answers

What is the clinical consequence of hereditary spherocytosis on oxygen transport?

<p>Less oxygen transport compared to normal erythrocytes (C)</p> Signup and view all the answers

Which ion channels are involved in ions transport in red blood cells?

<p>Calcium-dependent potassium channels (B)</p> Signup and view all the answers

What controls the mitotic activity and differentiation of progenitor cells?

<p>Specific hemopoietic factors (D)</p> Signup and view all the answers

Which cytokine is NOT involved in the control of erythropoiesis?

<p>Interferon (B)</p> Signup and view all the answers

At what stage does Hb synthesis start during erythropoiesis?

<p>Polychromatophilic erythroblasts (D)</p> Signup and view all the answers

Which stage in erythropoiesis results in the nucleus becoming eccentric for expulsion?

<p>Orthochromatophilic erythroblast (B)</p> Signup and view all the answers

What is a distinguishing feature of reticulocytes?

<p>They are spherical with remnants of ribosomes (D)</p> Signup and view all the answers

What is responsible for the MNS blood groups among transmembrane glycoproteins?

<p>Glycophorin A (B)</p> Signup and view all the answers

Which specific carbohydrate chains on the red blood cell plasmalemma determine an individual's blood group?

<p>Inherited carbohydrate chains (C)</p> Signup and view all the answers

What regulates the process of hemopoiesis during which stem cells differentiate into mature blood cells?

<p>Growth factors and cytokines (D)</p> Signup and view all the answers

Which cells are responsible for the formation of various progenitor cells during hemopoiesis?

<p>Pluripotent hemopoietic stem cells (PHSCs) (D)</p> Signup and view all the answers

What accounts for about 0.1% of the nucleated cell population of bone marrow and gives rise to two types of multipotential hemopoietic stem cells?

<p>Pluripotent hemopoietic stem cells (PHSCs) (D)</p> Signup and view all the answers

What is the main role of haemoglobin in red blood cells?

<p>Facilitating gaseous exchange (B)</p> Signup and view all the answers

Which component is responsible for maintaining the biconcave disk shape of erythrocytes?

<p>Spectrin (A)</p> Signup and view all the answers

What clinical condition results from the synthesis of abnormal spectrin?

<p>Hereditary spherocytosis (D)</p> Signup and view all the answers

Which ion channels are involved in ions transport in red blood cells, according to the text?

<p>Calcium-dependent potassium channels and Na+-K+ ATPase (B)</p> Signup and view all the answers

What is the main reason for residents living at higher altitudes having more red blood cells?

<p>Increased production of erythropoietin in response to low oxygen levels (A)</p> Signup and view all the answers

What is the significance of the biconcave disc-like shape of erythrocytes?

<p>It allows for a greater amount of hemoglobin to be packed into the cell (B)</p> Signup and view all the answers

Why do erythrocytes expel all cell organelles and the nucleus during their development in the bone marrow?

<p>To provide more space for hemoglobin within the cell (B)</p> Signup and view all the answers

What happens when red blood cells display a group of oligosaccharides on their surface?

<p>They are destroyed by macrophages in the spleen, bone marrow, and liver (B)</p> Signup and view all the answers

How does the lack of a nucleus benefit mature erythrocytes in their function?

<p>Provides more space for storing hemoglobin molecules (B)</p> Signup and view all the answers

Which stage of erythropoiesis is characterized by abundant ribosomes for hemoglobin synthesis?

<p>Basophilic erythroblast (A)</p> Signup and view all the answers

What is the main physiological function of steel factor in erythropoiesis?

<p>Promoting differentiation of hematopoietic stem cells into erythroid progenitor cells (D)</p> Signup and view all the answers

Which cytokine is involved in the control of erythropoiesis but is not specifically mentioned in the text?

<p>Interleukin-7 (IL-7) (B)</p> Signup and view all the answers

What is the defining characteristic of a reticulocyte?

<p>Presence of a nucleus (B)</p> Signup and view all the answers

During which stage of erythropoiesis does the nucleus become eccentric in preparation for expulsion?

<p>Orthochromatophilic erythroblast (B)</p> Signup and view all the answers

Which cell population is responsible for the formation of various progenitor cells during hemopoiesis?

<p>Multipotential hemopoietic stem cells (MHSCs) (C)</p> Signup and view all the answers

What role do specific inherited carbohydrate chains play in the red blood cell plasmalemma?

<p>Acting as antigens and determining blood group (B)</p> Signup and view all the answers

What regulates the type of blood cells formed and their rate of formation during hemopoiesis?

<p>Growth factors (D)</p> Signup and view all the answers

Which stage of cell development results in stem cells differentiating through several intermediate stages to give rise to mature blood cells?

<p>Intermediate progenitor cell stage (D)</p> Signup and view all the answers

Which factor accounts for about 0.1% of the nucleated cell population of bone marrow and gives rise to two types of multipotential hemopoietic stem cells?

<p>Pluripotential hemopoietic stem cells (PHSCs) (B)</p> Signup and view all the answers

What is the main function of hemoglobin in red blood cells?

<p>Transporting oxygen from the lungs to tissues (D)</p> Signup and view all the answers

What is the significance of the hematocrit value in relation to red blood cells?

<p>Measuring the percentage of red blood cells in whole blood (D)</p> Signup and view all the answers

Why do mature red blood cells lack a nucleus?

<p>To increase their internal space for oxygen transport (D)</p> Signup and view all the answers

In which capillaries do red blood cells pick up oxygen and form oxyhemoglobin?

<p>Pulmonary capillaries (D)</p> Signup and view all the answers

What is the normal range of red blood cell count in adults per microliter of blood?

<p>$4.5$ to $5.5$ million cells (B)</p> Signup and view all the answers

What is the primary role of red blood cells in the body?

<p>Transporting oxygen to tissues (B)</p> Signup and view all the answers

How does hemoglobin change when it reaches systemic capillaries?

<p>It releases most of its oxygen and becomes reduced hemoglobin (A)</p> Signup and view all the answers

Why are mature red blood cells highly specialized for their oxygen transport function?

<p>As they lack a nucleus, all internal space is available for oxygen transport (B)</p> Signup and view all the answers

What is responsible for the majority of erythropoietin production in the body?

<p>Kidney (A)</p> Signup and view all the answers

Which hormone promotes tissue metabolism in general and is required for erythropoiesis?

<p>Thyroxine (C)</p> Signup and view all the answers

In what organ does erythropoiesis primarily occur during embryonic life?

<p>Liver (A)</p> Signup and view all the answers

What deficiency can result from the destruction of bone marrow by irradiation, chemicals, drugs, or bacterial toxins?

<p>Aplastic anemia (C)</p> Signup and view all the answers

What factor stimulates the rate of red blood cell production in response to hypoxia?

<p>Erythropoietin (C)</p> Signup and view all the answers

Which organ secretes a small amount of erythropoietin?

<p>Kidneys (A)</p> Signup and view all the answers

When O2 transport to tissues exceeds normal levels, what happens to the production of erythropoietin?

<p>Decreases (D)</p> Signup and view all the answers

Which factor is essential for the maturation of red blood cells, important for nuclear maturation and cell division of red cell precursors?

<p>Vitamin B12 (C)</p> Signup and view all the answers

What does a healthy liver manufacture and store that is essential for normal red blood cell formation?

<p>Globin and iron (A)</p> Signup and view all the answers

What is the primary regulating factor for erythropoiesis in the body?

<p>Oxygen levels (C)</p> Signup and view all the answers

What vitamins are essential for the maturation of red blood cells, aiding in nuclear maturation and cell division?

<p>Vitamin B12 and folic acid (B)</p> Signup and view all the answers

Which substance is NOT necessary for the development and maturation of erythrocytes, according to the text?

<p>Iron (A)</p> Signup and view all the answers

Which external source influences general metabolism, growth of body tissues including bone marrow, but is not specific to red blood cell formation?

<p>Vitamin C (C)</p> Signup and view all the answers

Where does erythropoiesis primarily occur during postnatal and adult life?

<p>Red bone marrow (B)</p> Signup and view all the answers

What type of food is the main source of Vitamin B12 according to the text?

<p>&quot;Animal food&quot; (A)</p> Signup and view all the answers

Which hormone is responsible for stimulating the red bone marrow to increase red blood cell production?

<p>Erythropoietin (B)</p> Signup and view all the answers

What is the primary function of the intrinsic factor produced by parietal cells in the stomach lining?

<p>Promote absorption of vitamin B12 (B)</p> Signup and view all the answers

What is the storage organ for absorbed vitamin B12 in the human body?

<p>Liver (A)</p> Signup and view all the answers

Which nutrient is essential for the formation of the heme part of hemoglobin?

<p>Iron (D)</p> Signup and view all the answers

What are the roles of copper and cobalt in hemoglobin synthesis?

<p>Catalysts for hemoglobin synthesis (B)</p> Signup and view all the answers

What is the average hemoglobin concentration in blood for men according to the text?

<p>$16 ext{ g/dl}$ (D)</p> Signup and view all the answers

How many heme fractions are present in each hemoglobin molecule?

<p>$4$ (D)</p> Signup and view all the answers

What is the main function of hemoglobin in red blood cells according to the text?

<p>$O_2$ and $CO_2$ transport (D)</p> Signup and view all the answers

Where are the majority of animal proteins that are superior in producing haemoglobin found?

<p>Muscles (D)</p> Signup and view all the answers

What compound is formed by the combination of Hb with CO2?

<p>Carbaminohaemoglobin (B)</p> Signup and view all the answers

Which derivative of Hb remains in the ferrous state?

<p>Oxyhaemoglobin (C)</p> Signup and view all the answers

What occurs when blood is exposed to drugs causing the conversion of Fe++ to Fe+++?

<p>Formation of Methaemoglobin (C)</p> Signup and view all the answers

Which compound has an affinity for CO that is 200 times more than its affinity for O2?

<p>Methaemoglobin (B)</p> Signup and view all the answers

What is the primary characteristic of Methaemoglobin?

<p>Contains Fe+++ instead of Fe++ (D)</p> Signup and view all the answers

Which type of Hb results when O2 is released from oxyhaemoglobin?

<p>Deoxyhaemoglobin (A)</p> Signup and view all the answers

What happens when Hb binds to carbon monoxide (CO)?

<p>Production of Carboxyhaemoglobin (C)</p> Signup and view all the answers

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