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Questions and Answers
Which receptor does FIV Env bind to initiate infection?
Which receptor does FIV Env bind to initiate infection?
- CD4
- CXCR4 (correct)
- CCR5
- ACE2
What is the function of reverse transcriptase in FIV replication?
What is the function of reverse transcriptase in FIV replication?
- It releases the viral genome
- It encodes viral core proteins
- It forms the template for new virions
- It copies the viral genome into DNA (correct)
What is the most common FIV subtype?
What is the most common FIV subtype?
- A (correct)
- B
- C
- D
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Study Notes
- Understanding virus structure and replication informs diagnostic testing and persistent infection outcome.
- FIV virion contains duplicate, single-stranded RNA genome.
- Three major genes encode viral core proteins, enzymes, and envelope glycoproteins.
- Env binds primary receptor CD134 to initiate infection and co-receptor CXCR4 for cell entry.
- Viral genome is released and copied into DNA by reverse transcriptase.
- Provirus can remain latent or form template for new virions.
- FIV mutates frequently, creating a pool of variant viruses.
- Phylogenetic classification of FIV into major subtypes or clades A to E.
- Subtype classification is complex and uncertain in predicting biological properties.
- Subtypes A, B, and C are most common with regional variation in prevalence.
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