Factors Influencing Enzyme Reaction Velocity
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Questions and Answers

Which of the following best defines enzyme kinetics?

  • The study of how enzymes are inhibited by drugs
  • The study of chemical reactions that are catalyzed by enzymes (correct)
  • The study of how enzymes work
  • The study of how enzymes control metabolism

    • What does the Michaelis-Menten equation describe?

  • How enzyme kinetics vary with substrate concentration (correct)
  • How enzyme activity is controlled
  • How enzyme inhibitors work
  • How enzymes form ES complexes

    • Who were the scientists behind the Michaelis-Menten equation?

  • Enzymes Part 2
  • Leonor Michaelis and Maud Menten (correct)
  • Clara Camargo and DVM
  • Carnotcycle WordPress

    • What is the Lineweaver-Burk plot used for?

    <p>To interpret 1/Vmax and 1/Km</p> Signup and view all the answers

    What are the two types of enzyme inhibition?

    <p>Competitive and noncompetitive</p> Signup and view all the answers

    How can competitive and noncompetitive inhibitors be explained using the Michaelis-Menten curve and Lineweaver-Burk plot?

    <p>By interpreting 1/Vmax and 1/Km values</p> Signup and view all the answers

    What is an example of an enzyme inhibitor?

    <p>Drugs</p> Signup and view all the answers

    Which factor affects the rate of an enzyme-catalyzed reaction until a maximal velocity is reached?

    <p>Substrate concentration</p> Signup and view all the answers

    What happens to the reaction velocity when the temperature is further elevated beyond the optimal temperature for most mammalian enzymes?

    <p>It decreases</p> Signup and view all the answers

    How does extreme pH conditions affect the reaction velocity of enzymes?

    <p>It decreases the reaction velocity</p> Signup and view all the answers

    What is the effect of a competitive inhibitor on the Vmax of an enzyme-catalyzed reaction?

    <p>It has no effect on Vmax</p> Signup and view all the answers

    How does a competitive inhibitor affect the Km for a given substrate?

    <p>It increases Km</p> Signup and view all the answers

    What is the effect of a competitive inhibitor on the Lineweaver-Burk plot?

    <p>Vmax is unchanged</p> Signup and view all the answers

    What is the effect of irreversible inhibitors on enzymes?

    <p>They denature enzymes</p> Signup and view all the answers

    Which of the following is true about the Michaelis-Menten kinetics?

    <p>Km is equal to the substrate concentration at which the reaction velocity is ½ Vmax</p> Signup and view all the answers

    Which of the following conclusions can be drawn from the Michaelis-Menten equation?

    <p>Enzyme 1 has a high affinity for its substrate because a low concentration of substrate is needed to half-saturate the enzyme</p> Signup and view all the answers

    Which of the following statements is true about the oxyhemoglobin dissociation curve?

    <p>It shows a sigmoidal curve</p> Signup and view all the answers

    Which type of kinetics do allosteric enzymes exhibit?

    <p>Sigmoidal curve</p> Signup and view all the answers

    Which of the following is true about the Lineweaver-Burk plot?

    <p>It is used to calculate Km and Vmax</p> Signup and view all the answers

    Which order of reaction is observed when [S] << Km?

    <p>Zero order</p> Signup and view all the answers

    Which of the following is true about the total enzyme concentration [E] in the Michaelis-Menten kinetics?

    <p>It does not change over time</p> Signup and view all the answers

    Which enzyme do statin drugs inhibit?

    <p>Cholesterol biosynthesis hydroxymethylglutaryl-CoA reductase</p> Signup and view all the answers

    What is the mechanism of action of statin drugs?

    <p>Prevent de novo cholesterol synthesis</p> Signup and view all the answers

    Where do noncompetitive inhibitors bind?

    <p>Allosteric site</p> Signup and view all the answers

    What is the effect of noncompetitive inhibitors on Vmax?

    <p>Decrease Vmax</p> Signup and view all the answers

    What is the effect of noncompetitive inhibitors on Km?

    <p>Km remains unchanged</p> Signup and view all the answers

    Which type of inhibitors bind at a site different from the substrate?

    <p>Noncompetitive inhibitors</p> Signup and view all the answers

    What is the main target of β-lactam antibiotics?

    <p>Enzymes important for bacterial cell wall synthesis</p> Signup and view all the answers

    What is the mechanism of action of ACE inhibitors?

    <p>Block the enzyme that cleaves angiotensin I to angiotensin II</p> Signup and view all the answers

    What does aspirin irreversibly inhibit?

    <p>Prostaglandin and thromboxane synthesis</p> Signup and view all the answers

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