Factors Affecting Drug Solubility

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Questions and Answers

What is the process of binding solvent to solute molecules called?

  • Hydration
  • Evaporation
  • Condensation
  • Solvation (correct)

Which ion has the largest heat of hydration?

  • Ca2+
  • Mg2+ (correct)
  • K+
  • Na+

What happens when ΔS is negative?

  • The disorder of the system is increased
  • The order of the system is decreased
  • The disorder of the system is decreased
  • The order of the system is increased (correct)

Which ion shows the most favorable interaction with water due to its greater charge density on the surface?

<p>Ba2+ (A)</p> Signup and view all the answers

What is the measure of energy released to the surrounding or energy absorbed from the surrounding?

<p>Enthalpy, H (B)</p> Signup and view all the answers

Which process involves heat being evolved when solvation takes place?

<p>Solvation (C)</p> Signup and view all the answers

Which ion has a large negative value for heat of solvation?

<p>Br- (D)</p> Signup and view all the answers

What does a small ion tend to have in terms of heat of hydration?

<p>Decrease in heat of hydration (A)</p> Signup and view all the answers

What do small ions tend to have in terms of ΔH° and ΔS°?

<p>Decrease in ΔH° and increase in ΔS° (D)</p> Signup and view all the answers

Which of the following is NOT one of the top 15 most common drug salts mentioned in the lecture?

<p>Bromide (C)</p> Signup and view all the answers

What is the relationship between heat of hydration and solute-solvent interaction?

<p>Heat of hydration is directly related to solute-solvent interaction. (D)</p> Signup and view all the answers

What is the effect of solution pH on drug solubility?

<p>Increases drug solubility (C)</p> Signup and view all the answers

Which equation is referenced when discussing the relationship between the extent of ionization, pKa, and pH?

<p>Henderson Hasselbalch equation (B)</p> Signup and view all the answers

What is the term used to describe the process of drug absorption from the gastrointestinal tract (GIT)?

<p>Drug absorption process (DAP) (C)</p> Signup and view all the answers

What theory is mentioned in the context of drug absorption process (DAP) in relation to pH?

<p>pH partition hypothesis (C)</p> Signup and view all the answers

What is the most common form in which over 50% of all drug molecules used in medicine exist?

<p>As salts (A)</p> Signup and view all the answers

How do ions interact with water?

<p>They form ion-dipole interactions with water molecules (D)</p> Signup and view all the answers

Which of the following is NOT mentioned as one of the top 15 most common drug salts?

<p>$KNO_3$ (C)</p> Signup and view all the answers

What is the percentage of drug molecules used in medicine that exist as acetate?

<p>2.5% (C)</p> Signup and view all the answers

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