Factors Affecting Drug Solubility
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Questions and Answers

What is the process of binding solvent to solute molecules called?

  • Hydration
  • Evaporation
  • Condensation
  • Solvation (correct)
  • Which ion has the largest heat of hydration?

  • Ca2+
  • Mg2+ (correct)
  • K+
  • Na+
  • What happens when ΔS is negative?

  • The disorder of the system is increased
  • The order of the system is decreased
  • The disorder of the system is decreased
  • The order of the system is increased (correct)
  • Which ion shows the most favorable interaction with water due to its greater charge density on the surface?

    <p>Ba2+</p> Signup and view all the answers

    What is the measure of energy released to the surrounding or energy absorbed from the surrounding?

    <p>Enthalpy, H</p> Signup and view all the answers

    Which process involves heat being evolved when solvation takes place?

    <p>Solvation</p> Signup and view all the answers

    Which ion has a large negative value for heat of solvation?

    <p>Br-</p> Signup and view all the answers

    What does a small ion tend to have in terms of heat of hydration?

    <p>Decrease in heat of hydration</p> Signup and view all the answers

    What do small ions tend to have in terms of ΔH° and ΔS°?

    <p>Decrease in ΔH° and increase in ΔS°</p> Signup and view all the answers

    Which of the following is NOT one of the top 15 most common drug salts mentioned in the lecture?

    <p>Bromide</p> Signup and view all the answers

    What is the relationship between heat of hydration and solute-solvent interaction?

    <p>Heat of hydration is directly related to solute-solvent interaction.</p> Signup and view all the answers

    What is the effect of solution pH on drug solubility?

    <p>Increases drug solubility</p> Signup and view all the answers

    Which equation is referenced when discussing the relationship between the extent of ionization, pKa, and pH?

    <p>Henderson Hasselbalch equation</p> Signup and view all the answers

    What is the term used to describe the process of drug absorption from the gastrointestinal tract (GIT)?

    <p>Drug absorption process (DAP)</p> Signup and view all the answers

    What theory is mentioned in the context of drug absorption process (DAP) in relation to pH?

    <p>pH partition hypothesis</p> Signup and view all the answers

    What is the most common form in which over 50% of all drug molecules used in medicine exist?

    <p>As salts</p> Signup and view all the answers

    How do ions interact with water?

    <p>They form ion-dipole interactions with water molecules</p> Signup and view all the answers

    Which of the following is NOT mentioned as one of the top 15 most common drug salts?

    <p>$KNO_3$</p> Signup and view all the answers

    What is the percentage of drug molecules used in medicine that exist as acetate?

    <p>2.5%</p> Signup and view all the answers

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