Podcast
Questions and Answers
What is the melting point of cocoa butter?
What is the melting point of cocoa butter?
- Between 30°C and 35°C (correct)
- Between 25°C and 30°C
- Between 35°C and 40°C
- Between 20°C and 25°C
What is the purpose of adding wax and spermaceti to cocoa butter?
What is the purpose of adding wax and spermaceti to cocoa butter?
- To increase its melting point
- To change its crystal structure
- To correct the lowered melting point due to certain drugs (correct)
- To decrease its melting point
What is the advantage of cocoa butter as a suppository base?
What is the advantage of cocoa butter as a suppository base?
- It is non-reactive and melts at body temperature (correct)
- It is highly reactive
- It can take up large quantities of water
- It is too brittle for use
What is the maximum amount of water that cocoa butter can take up?
What is the maximum amount of water that cocoa butter can take up?
What is the purpose of 'seeding' in cocoa butter crystallization?
What is the purpose of 'seeding' in cocoa butter crystallization?
What is the temperature at which the α form of cocoa butter is obtained?
What is the temperature at which the α form of cocoa butter is obtained?
What is the characteristic of cocoa butter that causes suppositories to adhere to molds?
What is the characteristic of cocoa butter that causes suppositories to adhere to molds?
How many crystalline states can cocoa butter exist in?
How many crystalline states can cocoa butter exist in?
What influences the diffusivity of a drug to the site of absorption?
What influences the diffusivity of a drug to the site of absorption?
What is the effect of a higher melting range on absorption from fatty bases?
What is the effect of a higher melting range on absorption from fatty bases?
What is the effect of increasing hydroxyl values on the absorption rate of polyethylene glycol bases?
What is the effect of increasing hydroxyl values on the absorption rate of polyethylene glycol bases?
What is the effect of adding hydrophobic colloidal silicon oxide to a fat base?
What is the effect of adding hydrophobic colloidal silicon oxide to a fat base?
What is the effect of increasing the percentage of the cross-linking agent ethylene glycol dimethacrylate in hydrogels of hydroxyethyl methacrylate?
What is the effect of increasing the percentage of the cross-linking agent ethylene glycol dimethacrylate in hydrogels of hydroxyethyl methacrylate?
What is the effect of adding an aqueous polymer to emulsion type bases?
What is the effect of adding an aqueous polymer to emulsion type bases?
What is the effect of salicylates on the rectal absorption of water-soluble antibiotics in lipophilic bases?
What is the effect of salicylates on the rectal absorption of water-soluble antibiotics in lipophilic bases?
What is typically included in the specifications for suppository bases?
What is typically included in the specifications for suppository bases?
At what temperature range is the solidified melt tempered?
At what temperature range is the solidified melt tempered?
What is the primary function of glycerin in glycerinated gelatin suppositories?
What is the primary function of glycerin in glycerinated gelatin suppositories?
What is the characteristic of glycerinated gelatin suppositories that requires them to be stored in a cool place?
What is the characteristic of glycerinated gelatin suppositories that requires them to be stored in a cool place?
What is the general formula of polyethylene glycols?
What is the general formula of polyethylene glycols?
What is the effect of increasing average molecular weight on the water solubility of polyethylene glycols?
What is the effect of increasing average molecular weight on the water solubility of polyethylene glycols?
Why are rectal suppositories usually not compressed as tablets?
Why are rectal suppositories usually not compressed as tablets?
What is the purpose of coating the compressed rectal suppository with water-soluble polyethylene glycol?
What is the purpose of coating the compressed rectal suppository with water-soluble polyethylene glycol?
What is the typical pH of the vagina that is achieved by using boric and/or phosphoric acid in vaginal tablets?
What is the typical pH of the vagina that is achieved by using boric and/or phosphoric acid in vaginal tablets?
What is the primary cause of fracturing of suppositories made with certain bases?
What is the primary cause of fracturing of suppositories made with certain bases?
What is the purpose of adding a small amount of Tween 80, Tween 85, or fatty acid monoglycerides to the suppository base?
What is the purpose of adding a small amount of Tween 80, Tween 85, or fatty acid monoglycerides to the suppository base?
What is the main factor that determines the weight of a suppository?
What is the main factor that determines the weight of a suppository?
What is the primary advantage of hand molding over compression molding?
What is the primary advantage of hand molding over compression molding?
What is the main disadvantage of compression molding?
What is the main disadvantage of compression molding?
What is the purpose of using starch or talc powder on the rolling surface and hands in hand molding?
What is the purpose of using starch or talc powder on the rolling surface and hands in hand molding?
What is the advantage of compression molding over hand molding in terms of sedimentation?
What is the advantage of compression molding over hand molding in terms of sedimentation?
What is the primary reason for weight variations between suppositories?
What is the primary reason for weight variations between suppositories?
What is the most commonly used method for producing suppositories?
What is the most commonly used method for producing suppositories?
Why is it important to melt the base material on a water or steam bath?
Why is it important to melt the base material on a water or steam bath?
What is the purpose of overwrapping or packaging suppositories individually?
What is the purpose of overwrapping or packaging suppositories individually?
What is the advantage of in-package molding for suppositories intended for tropical climates?
What is the advantage of in-package molding for suppositories intended for tropical climates?
What is a disadvantage of in-package molding?
What is a disadvantage of in-package molding?
Why are active ingredients emulsified or suspended in the melted base material?
Why are active ingredients emulsified or suspended in the melted base material?
What is the purpose of cooling stations in in-package molding?
What is the purpose of cooling stations in in-package molding?
What is a benefit of in-package molding over traditional pour molding?
What is a benefit of in-package molding over traditional pour molding?
