Podcast
Questions and Answers
Which of the following represents the typical progression of squamous neoplasms associated with ocular surface squamous neoplasia (OSSN)?
Which of the following represents the typical progression of squamous neoplasms associated with ocular surface squamous neoplasia (OSSN)?
- Carcinoma in situ → Mild dysplasia → Invasive squamous cell carcinoma
- Invasive squamous cell carcinoma → Carcinoma in situ → Mild dysplasia
- Mild dysplasia → Carcinoma in situ → Invasive squamous cell carcinoma (correct)
- Mild dysplasia → Invasive squamous cell carcinoma → Carcinoma in situ
What characteristic helps differentiate a conjunctival nevus from a conjunctival melanoma?
What characteristic helps differentiate a conjunctival nevus from a conjunctival melanoma?
- Conjunctival nevi originate from primary acquired melanosis with atypia (C-MIN), while melanomas do not.
- Conjunctival nevi are commonly found in fair-skinned, middle-aged individuals, while melanomas are found in children/adolescents.
- Conjunctival nevi contain subepithelial cysts, while melanomas usually do not. (correct)
- Conjunctival nevi are typically unilateral, while melanomas are bilateral.
A patient is diagnosed with conjunctival melanoma. What is the most likely initial site of metastasis?
A patient is diagnosed with conjunctival melanoma. What is the most likely initial site of metastasis?
- Lungs
- Cervical Lymph Nodes
- Parotid or Submandibular Lymph Nodes (correct)
- Brain
Which of the following factors is most indicative of a higher risk of mortality associated with conjunctival melanoma?
Which of the following factors is most indicative of a higher risk of mortality associated with conjunctival melanoma?
What is the significance of the limbus in the context of ocular neoplasms?
What is the significance of the limbus in the context of ocular neoplasms?
A patient presents with goblet cell loss. This finding is most likely associated with which condition?
A patient presents with goblet cell loss. This finding is most likely associated with which condition?
Why is it essential to evaluate a pterygium histologically?
Why is it essential to evaluate a pterygium histologically?
A fair-skinned, middle-aged patient presents with a unilateral conjunctival lesion. Histopathology reveals primary acquired melanosis with atypia (C-MIN). Which of the following neoplasms is most likely to develop from this condition?
A fair-skinned, middle-aged patient presents with a unilateral conjunctival lesion. Histopathology reveals primary acquired melanosis with atypia (C-MIN). Which of the following neoplasms is most likely to develop from this condition?
What is a key difference in the location of conjunctival nevi compared to OSSN and melanoma?
What is a key difference in the location of conjunctival nevi compared to OSSN and melanoma?
In the context of neoplasms, where is the fornix considered a high-yield biopsy site?
In the context of neoplasms, where is the fornix considered a high-yield biopsy site?
Which of these neoplasms is considered benign?
Which of these neoplasms is considered benign?
What percentage of conjunctival melanomas contain BRAF V600 mutations?
What percentage of conjunctival melanomas contain BRAF V600 mutations?
What is the typical age demographic for patients who develop conjunctival nevi?
What is the typical age demographic for patients who develop conjunctival nevi?
What is the risk of melanoma development associated with incomplete treatment of primary acquired melanosis with atypia (C-MIN)?
What is the risk of melanoma development associated with incomplete treatment of primary acquired melanosis with atypia (C-MIN)?
Which of the following viruses is associated with Ocular Surface Squamous Neoplasia (OSSN)?
Which of the following viruses is associated with Ocular Surface Squamous Neoplasia (OSSN)?
What is the typical laterality of conjunctival melanoma?
What is the typical laterality of conjunctival melanoma?
What percentage of patients with conjunctival melanoma experience mortality?
What percentage of patients with conjunctival melanoma experience mortality?
Which of the following is the best treatment strategy for conjunctival melanoma?
Which of the following is the best treatment strategy for conjunctival melanoma?
A doctor suspects sarcoidosis or lymphoma. Which location is the most appropriate place to obtain a biopsy?
A doctor suspects sarcoidosis or lymphoma. Which location is the most appropriate place to obtain a biopsy?
A patient is diagnosed with conjunctival melanoma. Besides the primary tumor site, where else should the physician check for metastasis?
A patient is diagnosed with conjunctival melanoma. Besides the primary tumor site, where else should the physician check for metastasis?
Flashcards
Squamous Neoplasms (OSSN)
Squamous Neoplasms (OSSN)
Tumors of the conjunctiva originating from squamous cells, often near the limbus. Progresses from mild dysplasia to invasive carcinoma.
Conjunctival Nevus
Conjunctival Nevus
A benign melanocytic tumor of the conjunctiva, typically found in children/adolescents, that does not cross the limbus.
Conjunctival Melanoma
Conjunctival Melanoma
A potentially deadly melanocytic tumor, typically unilateral, in fair-skinned middle-aged individuals that originates from primary acquired melanosis. High rate of recurrence with high mortality.
Conjunctival Nevus Characteristics
Conjunctival Nevus Characteristics
Signup and view all the flashcards
Fornix Biopsy Site
Fornix Biopsy Site
Signup and view all the flashcards
Goblet Cell Loss
Goblet Cell Loss
Signup and view all the flashcards
Limbus origin
Limbus origin
Signup and view all the flashcards
Lymphatic metastasis location
Lymphatic metastasis location
Signup and view all the flashcards
Study Notes
- Neoplasms are abnormal growths of tissue.
Squamous Neoplasms
- Squamous neoplasms start near the limbus.
- They progress from mild dysplasia to carcinoma in situ, and finally to invasive squamous cell carcinoma.
- These neoplasms are also known as ocular surface squamous neoplasia (OSSN).
- OSSN is associated with HPV types 16 & 18.
Melanocytic Neoplasms
- These include Conjunctival Nevus and Conjunctival Melanoma.
Conjunctival Nevus
- Common and benign in children/adolescents.
- Nevi do not cross the limbus.
- They contain subepithelial cysts.
- Nevi may become inflamed juvenile nevi.
Conjunctival Melanoma
- Conjunctival melanomas are typically unilateral.
- They usually appear in fair-skinned, middle-aged individuals.
- Melanomas originate from primary acquired melanosis with atypia (C-MIN).
- Incomplete treatment of melanomas leads to melanoma in 50–90% of cases.
- Up to 40% of these melanomas have BRAF V600 mutations.
- Melanoma can spread to the parotid or submandibular lymph nodes.
- Conjunctival melanoma has a 25% mortality rate.
- Early removal of the precursor lesion yields best results.
Key Clinical Points
- The fornix is a high-yield biopsy site for sarcoidosis and lymphoma.
- Goblet cell loss leads to dry eye.
- Pterygium should be evaluated histologically.
- OSSN and melanoma originate at the limbus.
- Lymphatic metastasis to parotid/submandibular nodes is common.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
