Extracellular Matrix Overview

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Questions and Answers

Which glycosaminoglycan is found in high amounts in the extracellular matrix of the central nervous system?

  • Heparin
  • Chondroitin sulfate (correct)
  • Keratan sulfate
  • Hyaluronic acid

What is the main function of proteoglycans in the extracellular matrix?

  • Serve as receptors for cell growth (correct)
  • Act as enzymes for matrix degradation
  • Participate in osmotic pressure regulation
  • Maintain bone mineralization

What is the main function of heparin among the glycosaminoglycans?

  • Bone mineralization
  • Cell growth regulation
  • Anticoagulant activity (correct)
  • Cell membrane formation

What is a common role of glycosaminoglycans like chondroitin sulfate and hyaluronic acid?

<p>Facilitate cell migration (B)</p> Signup and view all the answers

Which glycosaminoglycan plays a critical role in corneal transparency?

<p>Keratan sulfate (D)</p> Signup and view all the answers

Where is dermatan sulfate mainly found in the body?

<p>Skin (D)</p> Signup and view all the answers

What is the primary role of keratan sulfate in the eye?

<p>Contribute to corneal transparency (D)</p> Signup and view all the answers

Which glycosaminoglycan is involved in the prevention of nerve endings repair after injury?

<p>Chondroitin sulfate (B)</p> Signup and view all the answers

What is a key function of heparan sulfate in the body?

<p>Cell communication (A)</p> Signup and view all the answers

What is a characteristic function of glycosaminoglycans like hyaluronic acid and chondroitin sulfate?

<p>Facilitate cell migration during wound repair (D)</p> Signup and view all the answers

What is the main role of fibronectin in the extracellular matrix?

<p>Cell adhesion and migration (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of collagen triple helix structure?

<p>Formation of hydroxyproline post-translationally (A)</p> Signup and view all the answers

How do proteoglycans contribute to the organization of the extracellular matrix?

<p>By binding to fibronectin and laminin (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of glycosaminoglycans (GAGs)?

<p>Disaccharide composition (C)</p> Signup and view all the answers

What is the primary function of laminin in the extracellular matrix?

<p>Cell adhesion and migration (B)</p> Signup and view all the answers

Which enzyme is responsible for the formation of hydroxylysine in collagen triple helix structure?

<p>Lysyl hydroxylase (C)</p> Signup and view all the answers

In which type of collagen is hydroxyproline formed by post-translational modification?

<p>Collagen type forming fibrils (B)</p> Signup and view all the answers

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