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Questions and Answers
Which route of drug administration involves injecting medication directly into a vein?
Which route of drug administration involves injecting medication directly into a vein?
- Rectal administration
- Inhaled administration
- Intravenous administration (correct)
- Oral administration
What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?
What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?
- Metabolism
- Distribution
- Elimination
- Absorption (correct)
Which mechanism of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?
Which mechanism of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?
- Facilitated diffusion
- Passive diffusion
- Endocytosis
- Active transport (correct)
Which route of drug administration involves placing medication between the lip and the teeth?
Which route of drug administration involves placing medication between the lip and the teeth?
Which process allows small hydrophobic molecules to passively diffuse across the cell membrane?
Which process allows small hydrophobic molecules to passively diffuse across the cell membrane?
What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?
What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?
Which type of transport requires specific types of proteins to facilitate the entry of hydrophilic agents into the cell?
Which type of transport requires specific types of proteins to facilitate the entry of hydrophilic agents into the cell?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
Which process is responsible for transporting large drugs into the cell?
Which process is responsible for transporting large drugs into the cell?
What is the best example of a drug that is transported across the cell membrane via a PO route?
What is the best example of a drug that is transported across the cell membrane via a PO route?
Which of the following is NOT one of the mechanisms by which drugs can be transported across cell membranes?
Which of the following is NOT one of the mechanisms by which drugs can be transported across cell membranes?
What factor can affect the absorption of drugs across cell membranes?
What factor can affect the absorption of drugs across cell membranes?
Which part of the gastrointestinal tract is the best site for absorption of weak acids?
Which part of the gastrointestinal tract is the best site for absorption of weak acids?
Which of the following diseases is likely to result in decreased absorption of drugs due to reduced blood flow to the gastrointestinal tract?
Which of the following diseases is likely to result in decreased absorption of drugs due to reduced blood flow to the gastrointestinal tract?
Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?
Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?
What is the role of surface area in drug absorption in the gastrointestinal tract?
What is the role of surface area in drug absorption in the gastrointestinal tract?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following conditions can increase the absorption of a drug in the gastrointestinal tract?
Which of the following conditions can increase the absorption of a drug in the gastrointestinal tract?
What is the role of microvilli in drug absorption?
What is the role of microvilli in drug absorption?
What is the function of P-glycoprotein in drug absorption?
What is the function of P-glycoprotein in drug absorption?
Which part of the gastrointestinal tract is the most acidic and where weak acids are best absorbed?
Which part of the gastrointestinal tract is the most acidic and where weak acids are best absorbed?
Which part of the gastrointestinal tract is the most alkaline and where weak bases are best absorbed?
Which part of the gastrointestinal tract is the most alkaline and where weak bases are best absorbed?
What is the role of an acidic environment in enhancing the absorption of weak acids?
What is the role of an acidic environment in enhancing the absorption of weak acids?
What is the role of an alkaline environment in enhancing the absorption of weak bases?
What is the role of an alkaline environment in enhancing the absorption of weak bases?
Which of the following routes of drug administration involves injecting medication into the dermis?
Which of the following routes of drug administration involves injecting medication into the dermis?
Which of the following routes of drug administration involves inhaling medication into the lungs?
Which of the following routes of drug administration involves inhaling medication into the lungs?
Which of the following routes of drug administration involves placing medication between the lips and the teeth?
Which of the following routes of drug administration involves placing medication between the lips and the teeth?
Which of the following mechanisms of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?
Which of the following mechanisms of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which characteristic(s) of a drug are important for it to passively diffuse across the cell membrane?
Which characteristic(s) of a drug are important for it to passively diffuse across the cell membrane?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
Which type of transport mechanism is used to shuttle large hydrophilic drugs across cell membranes?
Which type of transport mechanism is used to shuttle large hydrophilic drugs across cell membranes?
Which route of drug administration allows for direct entry of the drug into the bloodstream without passing through a membrane?
Which route of drug administration allows for direct entry of the drug into the bloodstream without passing through a membrane?
Which process involves the drug binding to receptors on the cell membrane and being taken into the cell via endocytosis?
Which process involves the drug binding to receptors on the cell membrane and being taken into the cell via endocytosis?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?
What is the role of microvilli in drug absorption?
What is the role of microvilli in drug absorption?
What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?
What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?
What is the function of P-glycoprotein in drug absorption?
What is the function of P-glycoprotein in drug absorption?
Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?
Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following diseases can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following diseases can decrease the absorption of a drug in the gastrointestinal tract?
Which of the following processes can result in multi-drug resistance in the gastrointestinal tract?
Which of the following processes can result in multi-drug resistance in the gastrointestinal tract?
Which of the following factors can increase the absorption of a drug in the gastrointestinal tract?
Which of the following factors can increase the absorption of a drug in the gastrointestinal tract?
What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?
What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?
What is the role of an acidic environment in enhancing the absorption of weak acids?
What is the role of an acidic environment in enhancing the absorption of weak acids?
What is the role of an alkaline environment in enhancing the absorption of weak bases?
What is the role of an alkaline environment in enhancing the absorption of weak bases?
Where in the gastrointestinal tract are weak acids best absorbed?
Where in the gastrointestinal tract are weak acids best absorbed?
Where in the gastrointestinal tract are weak bases best absorbed?
Where in the gastrointestinal tract are weak bases best absorbed?
What is the function of microvilli in drug absorption?
What is the function of microvilli in drug absorption?
Which part of the gastrointestinal tract is the best site for absorption of weak bases?
Which part of the gastrointestinal tract is the best site for absorption of weak bases?
What effect does diarrhea have on drug absorption in the gastrointestinal tract?
What effect does diarrhea have on drug absorption in the gastrointestinal tract?
Which disease can decrease the surface area of the intestines and therefore decrease drug absorption?
Which disease can decrease the surface area of the intestines and therefore decrease drug absorption?
What is the best route of drug administration in situations where there is reduced blood flow to the organs?
What is the best route of drug administration in situations where there is reduced blood flow to the organs?
Which mechanism of drug absorption depends on the movement of the drug across the cell membrane via passive transport, facilitated diffusion, active transport, or endocytosis?
Which mechanism of drug absorption depends on the movement of the drug across the cell membrane via passive transport, facilitated diffusion, active transport, or endocytosis?
Study Notes
Drug Administration Routes
- The intravenous route involves injecting medication directly into a vein.
Processes of Drug Absorption
- Absorption through the gastrointestinal tract involves shutting the drug from the lumen into the vasculature.
- Passive diffusion allows small hydrophobic molecules to pass across the cell membrane.
- Facilitated diffusion depends on specific transport mechanisms to shuttle the drug across cell membranes.
- Active transport requires ATP and pumps a drug from areas of low concentration to areas of high concentration.
- Endocytosis is responsible for transporting large drugs into the cell.
Characteristics of Drugs for Absorption
- For a drug to easily pass across the lipid bilayer via passive diffusion, it needs to be hydrophobic and have a low molecular weight.
- Specific transport mechanisms are required for the entry of hydrophilic agents into the cell.
Factors Affecting Drug Absorption
- Decreased blood flow to the gastrointestinal tract can affect drug absorption.
- Surface area is important for drug absorption in the gastrointestinal tract.
- Microvilli increase the surface area for drug absorption.
- P-glycoprotein is responsible for pumping drugs out of cells, decreasing absorption.
- Weak acids are best absorbed in the duodenum, the most acidic part of the gastrointestinal tract.
- Weak bases are best absorbed in the ileum, the most alkaline part of the gastrointestinal tract.
Other Routes of Drug Administration
- Subcutaneous administration involves injecting medication into the dermis.
- Inhalation administration involves inhaling medication into the lungs.
- Sublingual administration involves placing medication between the lips and the teeth.
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Description
Test your knowledge on weak acids and their absorption in this quiz. Explore the importance of weak acid formation in an acidic environment and its impact on drug delivery.
