Drug Absorption
54 Questions
7 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which route of drug administration involves injecting medication directly into a vein?

  • Rectal administration
  • Inhaled administration
  • Intravenous administration (correct)
  • Oral administration
  • What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?

  • Metabolism
  • Distribution
  • Elimination
  • Absorption (correct)
  • Which mechanism of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?

  • Facilitated diffusion
  • Passive diffusion
  • Endocytosis
  • Active transport (correct)
  • Which route of drug administration involves placing medication between the lip and the teeth?

    <p>Buccal administration</p> Signup and view all the answers

    Which process allows small hydrophobic molecules to passively diffuse across the cell membrane?

    <p>Simple diffusion</p> Signup and view all the answers

    What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?

    <p>Small and hydrophobic</p> Signup and view all the answers

    Which type of transport requires specific types of proteins to facilitate the entry of hydrophilic agents into the cell?

    <p>Facilitated diffusion</p> Signup and view all the answers

    Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?

    <p>Active transport</p> Signup and view all the answers

    Which process is responsible for transporting large drugs into the cell?

    <p>Endocytosis</p> Signup and view all the answers

    What is the best example of a drug that is transported across the cell membrane via a PO route?

    <p>B12</p> Signup and view all the answers

    Which of the following is NOT one of the mechanisms by which drugs can be transported across cell membranes?

    <p>Exocytosis</p> Signup and view all the answers

    What factor can affect the absorption of drugs across cell membranes?

    <p>All of the above</p> Signup and view all the answers

    Which part of the gastrointestinal tract is the best site for absorption of weak acids?

    <p>Proximal duodenum</p> Signup and view all the answers

    Which of the following diseases is likely to result in decreased absorption of drugs due to reduced blood flow to the gastrointestinal tract?

    <p>Septic shock</p> Signup and view all the answers

    Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?

    <p>Diarrhea</p> Signup and view all the answers

    What is the role of surface area in drug absorption in the gastrointestinal tract?

    <p>Increased surface area enhances drug absorption</p> Signup and view all the answers

    Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?

    <p>Presence of P-glycoprotein</p> Signup and view all the answers

    Which of the following conditions can increase the absorption of a drug in the gastrointestinal tract?

    <p>Constipation</p> Signup and view all the answers

    What is the role of microvilli in drug absorption?

    <p>They increase the total surface area for absorption</p> Signup and view all the answers

    What is the function of P-glycoprotein in drug absorption?

    <p>It inhibits drug absorption by pushing drugs back into the gastrointestinal tract</p> Signup and view all the answers

    Which part of the gastrointestinal tract is the most acidic and where weak acids are best absorbed?

    <p>Stomach</p> Signup and view all the answers

    Which part of the gastrointestinal tract is the most alkaline and where weak bases are best absorbed?

    <p>Distal small intestine</p> Signup and view all the answers

    What is the role of an acidic environment in enhancing the absorption of weak acids?

    <p>It increases the concentration of protons</p> Signup and view all the answers

    What is the role of an alkaline environment in enhancing the absorption of weak bases?

    <p>It decreases the concentration of protons</p> Signup and view all the answers

    Which of the following routes of drug administration involves injecting medication into the dermis?

    <p>Intramuscular injections</p> Signup and view all the answers

    Which of the following routes of drug administration involves inhaling medication into the lungs?

    <p>Inhaled administration</p> Signup and view all the answers

    Which of the following routes of drug administration involves placing medication between the lips and the teeth?

    <p>Sublingual administration</p> Signup and view all the answers

    Which of the following mechanisms of drug absorption depends on specific transport mechanisms to shuttle the drug across cell membranes?

    <p>Facilitated diffusion</p> Signup and view all the answers

    Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?

    <p>A decrease in gastric acid production</p> Signup and view all the answers

    Which characteristic(s) of a drug are important for it to passively diffuse across the cell membrane?

    <p>Small and hydrophobic</p> Signup and view all the answers

    Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?

    <p>Active transport</p> Signup and view all the answers

    Which type of transport mechanism is used to shuttle large hydrophilic drugs across cell membranes?

    <p>Bulk transport</p> Signup and view all the answers

    Which route of drug administration allows for direct entry of the drug into the bloodstream without passing through a membrane?

    <p>Intravenous</p> Signup and view all the answers

    Which process involves the drug binding to receptors on the cell membrane and being taken into the cell via endocytosis?

    <p>Bulk transport</p> Signup and view all the answers

    Which process requires ATP and pumps a drug from areas of low concentration to areas of high concentration?

    <p>Active transport</p> Signup and view all the answers

    What is the role of microvilli in drug absorption?

    <p>To increase surface area for absorption</p> Signup and view all the answers

    What characteristic(s) does a drug need to have in order to easily pass across the lipid bilayer via passive diffusion?

    <p>Hydrophobic and small</p> Signup and view all the answers

    What is the function of P-glycoprotein in drug absorption?

    <p>To pump drugs out of the cell</p> Signup and view all the answers

    Which factor is likely to decrease the absorption of a drug in the gastrointestinal tract?

    <p>Presence of P-glycoprotein</p> Signup and view all the answers

    Which of the following factors can decrease the absorption of a drug in the gastrointestinal tract?

    <p>Total surface area</p> Signup and view all the answers

    Which of the following diseases can decrease the absorption of a drug in the gastrointestinal tract?

    <p>Inflammatory bowel disease</p> Signup and view all the answers

    Which of the following processes can result in multi-drug resistance in the gastrointestinal tract?

    <p>P-glycoprotein inhibition</p> Signup and view all the answers

    Which of the following factors can increase the absorption of a drug in the gastrointestinal tract?

    <p>Blood flow</p> Signup and view all the answers

    What is the term for the process by which a drug is shuttled from the lumen of the gastrointestinal tract into the lumen of the vasculature?

    <p>Absorption</p> Signup and view all the answers

    What is the role of an acidic environment in enhancing the absorption of weak acids?

    <p>To convert weak acids from nonpolar non-charge form to polar charge form</p> Signup and view all the answers

    What is the role of an alkaline environment in enhancing the absorption of weak bases?

    <p>To convert weak bases from polar charge form to nonpolar non-charge form</p> Signup and view all the answers

    Where in the gastrointestinal tract are weak acids best absorbed?

    <p>Proximal duodenum</p> Signup and view all the answers

    Where in the gastrointestinal tract are weak bases best absorbed?

    <p>Ilium</p> Signup and view all the answers

    What is the function of microvilli in drug absorption?

    <p>To increase surface area for drug absorption</p> Signup and view all the answers

    Which part of the gastrointestinal tract is the best site for absorption of weak bases?

    <p>Distal ilium</p> Signup and view all the answers

    What effect does diarrhea have on drug absorption in the gastrointestinal tract?

    <p>It decreases drug absorption</p> Signup and view all the answers

    Which disease can decrease the surface area of the intestines and therefore decrease drug absorption?

    <p>All of the above</p> Signup and view all the answers

    What is the best route of drug administration in situations where there is reduced blood flow to the organs?

    <p>Intravenous</p> Signup and view all the answers

    Which mechanism of drug absorption depends on the movement of the drug across the cell membrane via passive transport, facilitated diffusion, active transport, or endocytosis?

    <p>Transcytosis</p> Signup and view all the answers

    Study Notes

    Drug Administration Routes

    • The intravenous route involves injecting medication directly into a vein.

    Processes of Drug Absorption

    • Absorption through the gastrointestinal tract involves shutting the drug from the lumen into the vasculature.
    • Passive diffusion allows small hydrophobic molecules to pass across the cell membrane.
    • Facilitated diffusion depends on specific transport mechanisms to shuttle the drug across cell membranes.
    • Active transport requires ATP and pumps a drug from areas of low concentration to areas of high concentration.
    • Endocytosis is responsible for transporting large drugs into the cell.

    Characteristics of Drugs for Absorption

    • For a drug to easily pass across the lipid bilayer via passive diffusion, it needs to be hydrophobic and have a low molecular weight.
    • Specific transport mechanisms are required for the entry of hydrophilic agents into the cell.

    Factors Affecting Drug Absorption

    • Decreased blood flow to the gastrointestinal tract can affect drug absorption.
    • Surface area is important for drug absorption in the gastrointestinal tract.
    • Microvilli increase the surface area for drug absorption.
    • P-glycoprotein is responsible for pumping drugs out of cells, decreasing absorption.
    • Weak acids are best absorbed in the duodenum, the most acidic part of the gastrointestinal tract.
    • Weak bases are best absorbed in the ileum, the most alkaline part of the gastrointestinal tract.

    Other Routes of Drug Administration

    • Subcutaneous administration involves injecting medication into the dermis.
    • Inhalation administration involves inhaling medication into the lungs.
    • Sublingual administration involves placing medication between the lips and the teeth.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on weak acids and their absorption in this quiz. Explore the importance of weak acid formation in an acidic environment and its impact on drug delivery.

    More Like This

    Use Quizgecko on...
    Browser
    Browser