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Questions and Answers
What is absorption in the context of drug processes?
What is absorption in the context of drug processes?
- The process by which a drug is converted into metabolites
- The process by which a drug enters the bloodstream (correct)
- The process by which a drug is excreted from the body
- The process by which a drug spreads throughout the body
What factor can affect the rate of absorption of a drug?
What factor can affect the rate of absorption of a drug?
- Metabolism of the drug
- Concentration of the drug (correct)
- Protein binding of the drug
- Excretion of the drug
What is distribution in the context of drug processes?
What is distribution in the context of drug processes?
- The process by which a drug spreads throughout the body (correct)
- The process by which a drug is excreted from the body
- The process by which a drug enters the bloodstream
- The process by which a drug is converted into metabolites
What can affect the distribution of a drug within the body?
What can affect the distribution of a drug within the body?
What is metabolism in the context of drug processes?
What is metabolism in the context of drug processes?
What is the process by which the body eliminates a drug and its metabolites from the body?
What is the process by which the body eliminates a drug and its metabolites from the body?
Which enzymes are involved in the metabolism process of drugs in the liver?
Which enzymes are involved in the metabolism process of drugs in the liver?
What can affect the rate of metabolism of a drug?
What can affect the rate of metabolism of a drug?
Which pathway is involved in the excretion of drugs through urine?
Which pathway is involved in the excretion of drugs through urine?
Why is it crucial to understand the ADME processes of a drug?
Why is it crucial to understand the ADME processes of a drug?
What role do the ADME processes play in drug development?
What role do the ADME processes play in drug development?
Which route of drug administration involves placing drugs into the rectum?
Which route of drug administration involves placing drugs into the rectum?
What factor can influence the rate and extent of drug absorption related to formulation composition?
What factor can influence the rate and extent of drug absorption related to formulation composition?
Which of these drug properties can affect the rate and extent of drug absorption?
Which of these drug properties can affect the rate and extent of drug absorption?
What is the most common route of drug administration involving swallowing tablets, capsules, or liquid solutions?
What is the most common route of drug administration involving swallowing tablets, capsules, or liquid solutions?
Which route of drug administration involves injecting drugs into the body, such as intravenous, subcutaneous, or intramuscular injections?
Which route of drug administration involves injecting drugs into the body, such as intravenous, subcutaneous, or intramuscular injections?
What is the first-pass effect in relation to drug bioavailability?
What is the first-pass effect in relation to drug bioavailability?
Which substance is designed to facilitate drug dissolution and absorption by reducing the surface tension of the gastrointestinal tract?
Which substance is designed to facilitate drug dissolution and absorption by reducing the surface tension of the gastrointestinal tract?
In which drug absorption model is the rate of absorption proportional to the concentration of the drug in the dosage form?
In which drug absorption model is the rate of absorption proportional to the concentration of the drug in the dosage form?
What do physiological factors such as gut motility and blood flow impact in relation to drug absorption?
What do physiological factors such as gut motility and blood flow impact in relation to drug absorption?
What are biologically inert compounds that can be converted into active drugs, thereby increasing the bioavailability of poorly absorbed drugs?
What are biologically inert compounds that can be converted into active drugs, thereby increasing the bioavailability of poorly absorbed drugs?
Flashcards
ADME
ADME
The four main processes (Absorption, Distribution, Metabolism, Excretion) that determine a drug's action, duration, and side effects in the body.
Drug Absorption
Drug Absorption
The process by which a drug enters the bloodstream from the site of administration.
Drug Distribution
Drug Distribution
The process by which a drug spreads throughout the body to reach its site of action.
Drug Metabolism
Drug Metabolism
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Drug Excretion
Drug Excretion
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Food
Food
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Physicochemical Properties
Physicochemical Properties
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CYP2C9, CYP3A4, and CYP2D6
CYP2C9, CYP3A4, and CYP2D6
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Kidneys
Kidneys
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Importance of ADME
Importance of ADME
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Lungs (Excretion)
Lungs (Excretion)
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Study Notes
Drug Absorption, Distribution, Metabolism, and Excretion (ADME)
Drug Absorption, Distribution, Metabolism, and Excretion (ADME) are the four main processes that occur within the body when a drug is ingested. These processes determine how a drug acts within the body, its duration of action, and its side effects.
Absorption
Absorption is the process by which a drug enters the bloodstream. This occurs when the drug molecules pass through the biological membrane to reach the bloodstream. The rate of absorption depends on several factors, including the site of administration, the concentration of the drug, and the properties of the drug itself. The rate of absorption can be affected by the presence of food in the stomach, which can delay the absorption of some drugs.
Distribution
Distribution is the process by which a drug spreads throughout the body to reach its site of action. The distribution of a drug depends on its physicochemical properties, such as its molecular weight, lipid solubility, and protein binding. The distribution of a drug can be affected by the body's blood flow, which is influenced by several factors, including the size of the blood vessels, the presence of organs, and the presence of physical activity.
Metabolism
Metabolism is the process by which the body converts a drug into metabolites, which are the end products of the drug. The process of metabolism involves several enzymes, including the liver enzymes CYP2C9, CYP3A4, and CYP2D6, as well as other enzymes in the body. The rate of metabolism can be affected by several factors, including the concentration of the drug, the presence of other drugs or substances in the body, and the activity of the enzymes involved in the metabolism process.
Excretion
Excretion is the process by which the body eliminates a drug and its metabolites from the body. The excretion process occurs through several pathways, including the kidneys, which excrete drugs and their metabolites through urine, and the lungs, which excrete drugs and their metabolites through exhaled air. The rate of excretion can be affected by several factors, including the properties of the drug, the body's ability to excrete the drug, and the presence of other substances in the body.
Understanding the ADME processes of a drug is crucial for predicting its behavior within the body and for designing drugs with improved therapeutic properties. These processes play a significant role in drug development, and understanding them can help prevent adverse drug reactions, reduce drug-drug interactions, and improve drug efficacy.
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