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Exploring the Initial T-B Interaction and Antibody Production Process
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Exploring the Initial T-B Interaction and Antibody Production Process

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Questions and Answers

Which cells migrate into B cell-rich follicles and are called follicular helper T (Tfh) cells?

  • Memory B cells
  • Germinal center cells
  • CD4+ T cells (correct)
  • Plasma cells

    • Which cytokine secreted by Tfh cells has an important but incompletely understood role in Tfh cell function?

  • Interleukin (IL)-21 (correct)
  • Interleukin (IL)-17
  • Interferon (IFN)-γ
  • Interleukin (IL)-4

    • Where do most of the events in fully developed antibody responses occur?

  • Plasma cells
  • Extra-follicular foci
  • Lymphoid follicles
  • Germinal centers (correct)

    • Which cells migrate back into the lymphoid follicle together with Tfh cells?

    <p>Activated B cells</p> Signup and view all the answers

    What is the doubling time of the proliferating B cells in the germinal center?

    <p>6 hours</p> Signup and view all the answers

    Where do B cells undergo extensive isotype switching and somatic mutation of Ig genes?

    <p>Dark zone of the germinal center</p> Signup and view all the answers

    What happens to B cells with the highest-affinity Ig receptors in the germinal center?

    <p>They migrate into the light zone</p> Signup and view all the answers

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