Podcast
Questions and Answers
What is the main function of antibodies in the immune system?
What is the main function of antibodies in the immune system?
To neutralize and eliminate infectious microbes and microbial toxins.
What is the significance of the third hypervariable region (CDR3) in antibody-antigen recognition?
What is the significance of the third hypervariable region (CDR3) in antibody-antigen recognition?
It is the most extensive contact with the antigen and the most variable of the three CDRs.
How is the strength of binding between an antibody and an antigen represented?
How is the strength of binding between an antibody and an antigen represented?
By a dissociation constant (Kd).
What term is used to describe the overall strength of attachment of an antibody to an antigen?
What term is used to describe the overall strength of attachment of an antibody to an antigen?
Where do class-switched, high-affinity antibody-secreting plasma cells migrate to after being produced in germinal centers?
Where do class-switched, high-affinity antibody-secreting plasma cells migrate to after being produced in germinal centers?
What range does the dissociation constant (Kd) of antibodies typically vary in humoral immune responses?
What range does the dissociation constant (Kd) of antibodies typically vary in humoral immune responses?
What is the role of TFH cells in the development of antibody responses?
What is the role of TFH cells in the development of antibody responses?
How are antigens retained for long periods in lymphoid tissues?
How are antigens retained for long periods in lymphoid tissues?
What process occurs in the germinal center that leads to the production of high-affinity antibodies?
What process occurs in the germinal center that leads to the production of high-affinity antibodies?
How do high-affinity IgG and IgA antibodies contribute to immunity?
How do high-affinity IgG and IgA antibodies contribute to immunity?
What is the half-life of circulating IgM in the bloodstream?
What is the half-life of circulating IgM in the bloodstream?
What type of cells capture and preserve opsonised antigens in the lymphoid tissues?
What type of cells capture and preserve opsonised antigens in the lymphoid tissues?
What is the role of the J chain in IgM produced by lamina propria plasma cells?
What is the role of the J chain in IgM produced by lamina propria plasma cells?
Where does the poly-Ig receptor transport IgM?
Where does the poly-Ig receptor transport IgM?
What initiates the classical complement pathway?
What initiates the classical complement pathway?
Which IgG subclasses are more efficient activators of complement?
Which IgG subclasses are more efficient activators of complement?
What is the function of opsonization in the immune system?
What is the function of opsonization in the immune system?
Where is the dominance of IgA production by intestinal plasma cells attributed?
Where is the dominance of IgA production by intestinal plasma cells attributed?
