Antibody Responses in Lymphoid Tissues

To neutralize and eliminate infectious microbes and microbial toxins.

It is the most extensive contact with the antigen and the most variable of the three CDRs.

By a dissociation constant (Kd).

<p>Avidity.</p> Signup and view all the answers

<p>Bone marrow.</p> Signup and view all the answers

<p>From about 10^-7 M to 10^-11 M.</p> Signup and view all the answers

<p>TFH cells direct antibody responses in lymphoid tissues.</p> Signup and view all the answers

<p>Antigens are retained in complexes known as iccosomes.</p> Signup and view all the answers

<p>Activated B cells undergo rounds of mutation and selection in the germinal center.</p> Signup and view all the answers

<p>High-affinity IgG and IgA antibodies can neutralize bacterial toxins and inhibit virus infectivity.</p> Signup and view all the answers

<p>Circulating IgM has a half-life of about 4 days.</p> Signup and view all the answers

<p>Subcapsular macrophages capture and preserve opsonised antigens.</p> Signup and view all the answers

<p>The J chain is covalently associated with IgM, forming a pentamer.</p> Signup and view all the answers

<p>The poly-Ig receptor transports IgM into intestinal secretions.</p> Signup and view all the answers

<p>The binding of complement protein C1 to IgG or IgM molecules bound to antigen initiates the classical complement pathway.</p> Signup and view all the answers

<p>IgG3 and IgG1 (in humans) are more efficient activators of complement than other subclasses.</p> Signup and view all the answers

<p>Opsonization is the process of coating microbes to promote phagocytosis by phagocytes.</p> Signup and view all the answers

<p>The dominance of IgA production is attributed to selective induction of IgA isotype switching in B cells in GALT and mesenteric lymph nodes.</p> Signup and view all the answers