Lecture 7: Th17/TFH cells

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What is the role of IL-17 and IL-22 in relation to epithelial cells?

Increasing division and shedding of epithelial cells

Inducing stromal and myeloid cells to produce G-CSF

Activating epithelial cells to produce antimicrobial peptides (correct)

Promoting the production of neutrophils

How does IL-22 contribute to hindering bacterial growth?

Inducing stromal and myeloid cells to produce chemokines

Increasing division and shedding of epithelial cells (correct)

Promoting the production of neutrophils

Enhancing attachment of bacteria to epithelium

Which type of cells do IL-17 and IL-22 induce to produce G-CSF?

Stromal and Myeloid Cells (correct)

B Cells

Epithelial Cells

Neutrophils

What is the main function of IL-17 on stromal and epithelial cells?

Inducing chemokine secretion Signup and view all the answers

How does IL-17 attract more TH17 cells?

By secreting chemokines that recruit additional TH17 cells Signup and view all the answers

Which cytokines do TH17 cells typically secrete in response to pathogens?

IL-21 and either a type 1, type 2, or type 3 response Signup and view all the answers

What is the role of T FH cells in activating B cells?

Secrete effector cytokines like IL-21 Signup and view all the answers

Which transcription factor is the master regulator for T FH cells?

Bcl-6 Signup and view all the answers

What is the main function of G-CSF in the immune response?

Drive differentiation of neutrophils from bone marrow precursors Signup and view all the answers

How do antibodies target IL-17 in psoriasis treatment?

Block signaling from the IL-17 receptor Signup and view all the answers

Which cytokines are secreted by TH17 cells to stimulate other cells to secrete more cytokines, chemokines, and antimicrobial peptides?

IL-17 and IL-22 Signup and view all the answers

What is the master transcriptional regulator of TH17 cells?

RORgT Signup and view all the answers

Which type of response is associated with TH17 cells?

Type 3 response Signup and view all the answers

Which transcription factor activates the secretion of IL-17 and IL-22 by TH17 cells?

Stat3 Signup and view all the answers

What is the effector cytokine secreted by TH17 cells to enhance neutrophil responses and mucosal immunity?

IL-17 Signup and view all the answers

In which autoimmune diseases are TH17 responses involved?

Rheumatoid Arthritis, Multiple Sclerosis, and Inflammatory Bowel Disease Signup and view all the answers

What was an important discovery in 2003 that led to the rethinking of the classic TH1 vs TH2 paradigm?

Identification of IL-22's role in autoimmunity Signup and view all the answers

'TH17 enhances neutrophil responses and mucosal immunity' is a statement that is primarily associated with:

'Type 3 response' Signup and view all the answers

'Therapies targeting IL-17 are currently being studied' implies that these therapies may be beneficial for treating:

'Autoimmune diseases' Signup and view all the answers