Lecture 7: Th17/TFH cells
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Questions and Answers

What is the role of IL-17 and IL-22 in relation to epithelial cells?

  • Increasing division and shedding of epithelial cells
  • Inducing stromal and myeloid cells to produce G-CSF
  • Activating epithelial cells to produce antimicrobial peptides (correct)
  • Promoting the production of neutrophils

    • How does IL-22 contribute to hindering bacterial growth?

  • Inducing stromal and myeloid cells to produce chemokines
  • Increasing division and shedding of epithelial cells (correct)
  • Promoting the production of neutrophils
  • Enhancing attachment of bacteria to epithelium

    • Which type of cells do IL-17 and IL-22 induce to produce G-CSF?

  • Stromal and Myeloid Cells (correct)
  • B Cells
  • Epithelial Cells
  • Neutrophils

    • What is the main function of IL-17 on stromal and epithelial cells?

    <p>Inducing chemokine secretion</p> Signup and view all the answers

    How does IL-17 attract more TH17 cells?

    <p>By secreting chemokines that recruit additional TH17 cells</p> Signup and view all the answers

    Which cytokines do TH17 cells typically secrete in response to pathogens?

    <p>IL-21 and either a type 1, type 2, or type 3 response</p> Signup and view all the answers

    What is the role of T FH cells in activating B cells?

    <p>Secrete effector cytokines like IL-21</p> Signup and view all the answers

    Which transcription factor is the master regulator for T FH cells?

    <p>Bcl-6</p> Signup and view all the answers

    What is the main function of G-CSF in the immune response?

    <p>Drive differentiation of neutrophils from bone marrow precursors</p> Signup and view all the answers

    How do antibodies target IL-17 in psoriasis treatment?

    <p>Block signaling from the IL-17 receptor</p> Signup and view all the answers

    Which cytokines are secreted by TH17 cells to stimulate other cells to secrete more cytokines, chemokines, and antimicrobial peptides?

    <p>IL-17 and IL-22</p> Signup and view all the answers

    What is the master transcriptional regulator of TH17 cells?

    <p>RORgT</p> Signup and view all the answers

    Which type of response is associated with TH17 cells?

    <p>Type 3 response</p> Signup and view all the answers

    Which transcription factor activates the secretion of IL-17 and IL-22 by TH17 cells?

    <p>Stat3</p> Signup and view all the answers

    What is the effector cytokine secreted by TH17 cells to enhance neutrophil responses and mucosal immunity?

    <p>IL-17</p> Signup and view all the answers

    In which autoimmune diseases are TH17 responses involved?

    <p>Rheumatoid Arthritis, Multiple Sclerosis, and Inflammatory Bowel Disease</p> Signup and view all the answers

    What was an important discovery in 2003 that led to the rethinking of the classic TH1 vs TH2 paradigm?

    <p>Identification of IL-22's role in autoimmunity</p> Signup and view all the answers

    'TH17 enhances neutrophil responses and mucosal immunity' is a statement that is primarily associated with:

    <p>'Type 3 response'</p> Signup and view all the answers

    'Therapies targeting IL-17 are currently being studied' implies that these therapies may be beneficial for treating:

    <p>'Autoimmune diseases'</p> Signup and view all the answers

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