30 Questions
Which lobe of the liver is the largest?
Right lobe
What percentage of blood supply to the liver is from the portal vein?
75-85%
Which of the following is NOT a metabolic function of the liver?
Vitamin metabolism
Which process involves the breakdown of fatty acids to ketones?
Ketogenesis
Which of the following is NOT synthesized by the liver?
Insulin
Which of the following is NOT a storage function of the liver?
Calcium
Which of the following is NOT excreted/secreted by the liver?
Insulin-like Growth Factor 1 (IGF-1)
Which function of the liver involves the purification, transformation, and clearance of substances?
Protective function
During which stage of pregnancy does the fetal liver produce red blood cells?
First trimester
Which of the following is NOT a component of bile secreted by the liver?
Urea
Which of the following is a risk factor for gallstone disease?
Having a FXR mutation
What is the most common type of primary liver tumor in childhood?
Hepatoblastoma
Which of the following is a histologic stage of primary biliary cholangitis (PBC)?
Florid duct lesion
What is the main cause of liver cysts?
Parasite infection
Which of the following is a feature of NASH?
Induction of cytochrome P4502E1
What is the mechanism of ALD (Alcoholic Liver Disease) inflammation?
Activation of innate immunity
Which of the following is a characteristic of hepatocellular carcinoma (HCC)?
Trabeculae, cords, and nests formation
What is the first hit in the MASH/NASH two-hit theory?
Fat accumulation in the liver
What is the main cause of cholelithiasis (gallstones)?
Obesity
What is the most common type of primary liver cell carcinoma?
Hepatocellular carcinoma
Which of the following is NOT a function of Kupffer cells in the liver?
Production of coagulation factors
Which enzyme is an indicator of liver function and is released from damaged hepatocytes?
Alanine aminotransferase (ALT or SGPT)
Which of the following is NOT a common cause of chronic liver injury?
Obesity
Which term is used to describe the combination of steatosis, inflammation, and hepatocyte ballooning in the liver?
Metabolic dysfunction associated steatohepatitis (MASH)
What is the most common cause of abnormal liver enzyme tests?
Fatty liver diseases
What is the estimated prevalence of liver steatosis in developed countries?
30-40%
What is the estimated prevalence of MASLD (metabolic dysfunction associated liver disease) in North America?
2-3%
What is the estimated prevalence of NASH with fibrosis in the United States?
2.1%
What is the estimated number of individuals in the United States with or will have NASH with fibrosis?
7,078,411
What is the incidence of NASH patients added to the liver transplant waiting list in 2017?
1,728
Test your knowledge on liver pathophysiology with this quiz! Learn about the macrostructure of the liver, its functions, and its role in metabolic processes. Perfect for healthcare professionals and students studying liver health.
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