Podcast
Questions and Answers
What is the primary purpose of the experiment involving pulmonary edema in rabbits?
What is the primary purpose of the experiment involving pulmonary edema in rabbits?
- To understand the control of blood pressure
- To learn the method of replication of experimental pulmonary edema (correct)
- To evaluate the effects of adrenaline on respiration
- To measure lung capacity in rabbits
Which factor does NOT affect the exchange between intra- and extra-vascular fluid?
Which factor does NOT affect the exchange between intra- and extra-vascular fluid?
- Capillary hydrostatic pressure
- Plasma colloid osmotic pressure
- Microvascular permeability
- Lung capacity (correct)
What is defined as an abnormal accumulation of fluid in the tissue space?
What is defined as an abnormal accumulation of fluid in the tissue space?
- Hydration
- Oedema
- Pulmonary edema (correct)
- Fibrosis
During the experiment, how is the pulmonary edema induced in the rabbits?
During the experiment, how is the pulmonary edema induced in the rabbits?
Which of the following is NOT a component of effective filtration pressure?
Which of the following is NOT a component of effective filtration pressure?
What substance is injected alongside adrenaline to influence blood pressure during the experiment?
What substance is injected alongside adrenaline to influence blood pressure during the experiment?
Which observation indicates the development of pulmonary edema in the rabbit?
Which observation indicates the development of pulmonary edema in the rabbit?
What is the main consequence of lymphatic drainage obstruction in the context of pulmonary edema?
What is the main consequence of lymphatic drainage obstruction in the context of pulmonary edema?
Flashcards
Edema
Edema
The abnormal accumulation of fluid in the tissue space or body cavities.
Pulmonary Edema
Pulmonary Edema
Fluid accumulation in the lung tissue spaces, causing respiratory distress.
Capillary Hydrostatic Pressure
Capillary Hydrostatic Pressure
Pressure exerted by blood inside capillaries, pushing fluid outward.
Plasma Colloid Osmotic Pressure
Plasma Colloid Osmotic Pressure
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Microvascular Permeability
Microvascular Permeability
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Lymphatic Drainage Obstruction
Lymphatic Drainage Obstruction
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Effective Filtration Pressure
Effective Filtration Pressure
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Saline Infusion
Saline Infusion
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Study Notes
Experimental Pulmonary Edema in Rabbits
- The study aims to replicate experimental pulmonary edema and understand its manifestations and mechanisms.
- Edema is the abnormal accumulation of fluid in tissue spaces or body cavities.
- Four factors influence fluid exchange between capillaries and tissues:
- Capillary hydrostatic pressure (↑)
- Plasma colloid osmotic pressure (↓)
- Microvascular permeability (↑)
- Lymphatic drainage obstruction
- Effective filtration pressure is calculated as (capillary filtration pressure + tissue colloidal osmotic pressure) - (tissue hydrostatic pressure + capillary colloidal osmotic pressure).
- Imbalances in fluid exchange lead to sodium and water retention.
- Analysis of glomerulotubular balance is important. Disruption results in various outcomes regarding glomerular filtration rate (GFR); normal GFR, decreased GFR, and increased GFR.
- Reabsorption changes relate to changes in urine output.
- Pulmonary edema involves fluid accumulation in lung tissue, specifically alveoli.
- Methods include inducing massive rapid fluid buildup in the marginal ear vein, adjusting blood pressure, and observing corneal reflection/muscle tension. Measurements may be taken with a stethoscope or via other means. The trachea is ligated before lung dissection
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