Experimental Pulmonary Edema in Rabbits

What is the primary purpose of the experiment involving pulmonary edema in rabbits?

Which factor does NOT affect the exchange between intra- and extra-vascular fluid?

What is defined as an abnormal accumulation of fluid in the tissue space?

During the experiment, how is the pulmonary edema induced in the rabbits?

Which of the following is NOT a component of effective filtration pressure?

What substance is injected alongside adrenaline to influence blood pressure during the experiment?

Which observation indicates the development of pulmonary edema in the rabbit?

What is the main consequence of lymphatic drainage obstruction in the context of pulmonary edema?

Experimental Pulmonary Edema in Rabbits

The study aims to replicate experimental pulmonary edema and understand its manifestations and mechanisms.
Edema is the abnormal accumulation of fluid in tissue spaces or body cavities.
Four factors influence fluid exchange between capillaries and tissues:
- Capillary hydrostatic pressure (↑)
- Plasma colloid osmotic pressure (↓)
- Microvascular permeability (↑)
- Lymphatic drainage obstruction
Effective filtration pressure is calculated as (capillary filtration pressure + tissue colloidal osmotic pressure) - (tissue hydrostatic pressure + capillary colloidal osmotic pressure).
Imbalances in fluid exchange lead to sodium and water retention.
Analysis of glomerulotubular balance is important. Disruption results in various outcomes regarding glomerular filtration rate (GFR); normal GFR, decreased GFR, and increased GFR.
Reabsorption changes relate to changes in urine output.
Pulmonary edema involves fluid accumulation in lung tissue, specifically alveoli.
Methods include inducing massive rapid fluid buildup in the marginal ear vein, adjusting blood pressure, and observing corneal reflection/muscle tension. Measurements may be taken with a stethoscope or via other means. The trachea is ligated before lung dissection

This quiz explores the mechanisms and manifestations of experimental pulmonary edema in rabbits. It covers fluid exchange factors, effective filtration pressure, and the impact of imbalances on glomerular filtration rates. Prepare to test your understanding of these critical physiological processes.