Exercise Biochemistry Overview

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Questions and Answers

What is the primary consequence of low pH in muscle cells during exercise?

  • It inhibits enzyme activity such as PFK. (correct)
  • It promotes ATP hydrolysis.
  • It activates lactate production.
  • It enhances myosin-actin binding.

Which process is responsible for converting pyruvate to lactate in muscle cells?

  • Phosphocreatine metabolism.
  • Myosin ATPase conversion.
  • Creatine kinase facilitation.
  • Lactate dehydrogenase (LDH) activation. (correct)

What adaptation to training is linked to improved lactate clearance?

  • Raised anaerobic threshold. (correct)
  • Reduced mitochondrial levels.
  • Increased lactate production.
  • Decreased capillary density.

During muscle contraction, what is the role of calcium?

<p>It activates ATP hydrolysis. (D)</p> Signup and view all the answers

Which factor contributes to muscle fatigue during intense exercise?

<p>Lactate accumulation. (A)</p> Signup and view all the answers

What is one of the implications of using beta-blockers in athletes?

<p>Dehydration effects (B)</p> Signup and view all the answers

What is a potential consequence of lactic acid formation during intense exercise?

<p>Reduced pH leading to enzyme inhibition (D)</p> Signup and view all the answers

Which of the following methods does NOT enhance athletic performance?

<p>Dopamine blockers (D)</p> Signup and view all the answers

In which type of exercise is the oxidative capacity expected to increase significantly?

<p>Marathons (B)</p> Signup and view all the answers

What effect does prolonged lactate production have on the body during exercise?

<p>Fatigue due to reduced ATP efficiency (B)</p> Signup and view all the answers

What primarily causes acute pain in muscles?

<p>Lactic acid buildup due to ischemia (B)</p> Signup and view all the answers

What is the main characteristic of Delayed-Onset Muscle Soreness (DOMS)?

<p>It is caused by inflammation and structural damage. (A)</p> Signup and view all the answers

Which process is primarily utilized during fasting to maintain energy?

<p>Utilization of stored fuels (B)</p> Signup and view all the answers

What is a significant risk associated with anabolic steroids?

<p>Hormonal imbalances (D)</p> Signup and view all the answers

What is the main effect of peptide hormones like EPO?

<p>To boost red blood cell production (A)</p> Signup and view all the answers

What type of exercise primarily relies on anaerobic glycolysis for energy?

<p>Sprint events (C)</p> Signup and view all the answers

What is the consequence of the extensive mobilization of energy reserves during exercise?

<p>Possible cardiovascular risks (B)</p> Signup and view all the answers

What action does phosphocreatine primarily facilitate in muscles?

<p>Rapid ATP regeneration (A)</p> Signup and view all the answers

What is the approximate amount of muscle glycogen stored in the body?

<p>300–400 g (A)</p> Signup and view all the answers

How much glycogen is stored in the liver to help maintain blood glucose levels?

<p>100 g (A)</p> Signup and view all the answers

Which of the following accurately describes the physiological effect of training on cardiorespiratory function?

<p>Elevated cardiac output enhances energy utilization (D)</p> Signup and view all the answers

What can be said about the efficiency of ATP production during exercise?

<p>Slow but efficient ATP production utilizes oxygen (B)</p> Signup and view all the answers

What characterizes the relationship between exercise and glycogen stores?

<p>Regular exercise enhances the utilization of stored glycogen for ATP (D)</p> Signup and view all the answers

Which of the following statements about energy sources during exercise is true?

<p>Utilizing oxygen allows for more efficient ATP generation (D)</p> Signup and view all the answers

What is the impact of elevated hemoglobin levels on exercise performance?

<p>They enhance oxygen delivery and aerobic capacity (D)</p> Signup and view all the answers

Which statement accurately reflects the role of glycogen in exercise performance?

<p>Glycogen stores in both muscle and liver are crucial for ATP generation (C)</p> Signup and view all the answers

What primarily contributes to the metabolic shift during prolonged aerobic exercise?

<p>Enhanced fatty acid oxidation (D)</p> Signup and view all the answers

Which muscle type is characterized by a higher capacity for aerobic metabolism?

<p>Type I (Slow-Twitch) (B)</p> Signup and view all the answers

During anaerobic activities, which energy source is primarily utilized?

<p>Glycogen (D)</p> Signup and view all the answers

What is the role of ATP and phosphocreatine during the initial stages of high-intensity exercise?

<p>Provide immediate energy resynthesis (C)</p> Signup and view all the answers

What is the primary function of electrolyte balance during recovery from exercise?

<p>Prevent dehydration (B)</p> Signup and view all the answers

What is the main benefit of increased capillarization in muscle tissue?

<p>Enhanced oxygen delivery to tissues (B)</p> Signup and view all the answers

What is the expected change in the NADH/NAD⁺ ratio during anaerobic exercise conditions?

<p>Increased NADH levels (D)</p> Signup and view all the answers

What is the purpose of isotonic drinks recommended during recovery?

<p>Help maintain electrolyte balance (C)</p> Signup and view all the answers

Flashcards

Beta-Blockers

A type of drug that blocks the effects of adrenaline, slowing down heart rate and reducing blood pressure.

Diuretics

Drugs that increase urine production, leading to fluid loss.

Lactic Acid

A substance produced in the body during intense exercise when there is insufficient oxygen.

Doping

Methods used to enhance performance in competitive settings, including blood transfusions, genetic modifications, and using performance-enhancing drugs.

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Increased Oxidative Capacity

The process of training your body to utilize fat as a source of energy during exercise.

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Metabolism

The process of breaking down nutrients to produce energy.

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Glycolysis

The chemical process of using glucose (sugar) for energy.

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Glycogen

A complex carbohydrate stored in the muscles and liver that provides energy for physical activity.

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Cardiac Output

The amount of blood pumped by the heart each minute.

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Hemoglobin

A protein in red blood cells that carries oxygen to the muscles.

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Cardiorespiratory Fitness

The ability of the body to take in, transport, and use oxygen.

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Aerobic Metabolism

The process of using oxygen to efficiently generate energy.

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Anaerobic Metabolism

The process of generating energy without using oxygen.

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Lactate production

Lactate dehydrogenase converts pyruvate to lactate, especially during intense exercise when oxygen is limited.

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Lactate and Fatigue

The build-up of lactate contributes to muscle fatigue as it lowers pH inhibiting key enzymes like PFK, reducing further energy production.

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Calcium's role in muscle contraction

Calcium ions trigger muscle contraction by binding to troponin, causing a shift in tropomyosin and exposing myosin binding sites on actin.

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ATP hydrolysis in muscle contraction

Myosin ATPase breaks down ATP into ADP and Pi during muscle contraction to provide energy for cross-bridge cycling.

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Adaptations to training in lactate production

Training adaptations include increased capillary density, mitochondria, and monocarboxylate transporter levels, leading to enhanced lactate clearance and a higher anaerobic threshold.

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Acute Pain

A type of pain caused by reduced blood flow to muscles and the buildup of waste products like lactic acid, often experienced after intense exercise or strenuous activity.

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Delayed-Onset Muscle Soreness (DOMS)

Pain that occurs 12-72 hours after exercise, caused by microscopic muscle tears and inflammation.

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Fasting

The breakdown of stored energy sources like glycogen in the body to provide energy.

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Anaerobic Exercise

A type of exercise that uses energy very quickly and doesn't require oxygen, leading to the buildup of lactic acid. Examples include sprinting or weightlifting.

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Phosphocreatine

A chemical compound that helps our body make energy quickly, but only for a short time.

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Anaerobic Glycolysis

The process of breaking down glycogen to make energy without oxygen, leading to the production of lactic acid.

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Anabolic Steroids

Artificial hormones that increase muscle mass but have serious health risks.

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Type I (Slow-Twitch) Muscle

A type of muscle fiber that contracts slowly and uses oxygen efficiently. They excel at endurance activities.

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Type II (Fast-Twitch) Muscle

A type of muscle fiber that contracts quickly and uses less oxygen. They are ideal for short bursts of intense activity.

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Cori Cycle

The process of converting lactate back to glucose in the liver. It's a way to replenish glycogen stores after intense exercise.

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Oxygen Restoration

The ability of the body to restore oxygen levels to muscles after exercise. This helps replenish oxygen stores and removes waste products.

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Energy Resynthesis

The process of replenishing energy stores (ATP and phosphocreatine) in the muscles after exercise.

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Lactate Clearance

The process of removing excess lactate from the bloodstream after exercise. This helps reduce muscle fatigue and soreness.

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Electrolyte Balance

Maintaining a balanced level of electrolytes in the body, especially during and after exercise. This is important for hydration and muscle function.

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Study Notes

Exercise Biochemistry Mind Map

  • Exercise Biochemistry: A study of metabolic processes during exercise.

1. Overview

  • Fasting vs. Exercise: Fasting utilizes stored fuels, while exercise demands sudden energy mobilization.
  • Anaerobic Exercise: Short, intense activities relying on rapid energy sources without oxygen.
    • Phosphocreatine: Rapid ATP regeneration (~4 sec).
    • Anaerobic Glycolysis: Glycogen converted to lactate and ATP.
  • Aerobic Exercise: Sustained activities using oxygen for efficient ATP production.
    • Glycogen: Primary energy source, stored in muscles (300-400g) and liver (100g).
    • Fatty Acids: Used as fuel during prolonged exercise, providing nearly unlimited energy reserves.
  • Muscle Types:
    • Type I (Slow-Twitch): High endurance, aerobic metabolism, uses fatty acids and glucose as fuel. Rich in mitochondria and myoglobin.
    • Type II (Fast-Twitch): Short bursts, anaerobic metabolism, uses creatine phosphate and glycogen as fuel.

2. Muscle Biochemistry

  • Muscle Contraction: Calcium binds to troponin, shifting tropomyosin to allow myosin-actin binding.
  • Energy Pathways: ATP hydrolysis provides energy for contraction; phosphocreatine regenerates ATP quickly.

3. Lactate and Fatigue

  • Lactate Production: Catalyzed by LDH, reoxidation of NADH, leading to a decrease in pH.
  • Metabolic Effects: Low pH inhibits enzymes, causing calcium pump malfunction and reduced ATP efficiency, contributing to muscle fatigue.
  • Lactate Clearance: Increased capillary density and monocarboxylate transporters enhance lactate removal.

4. Adaptations to Training

  • Cardiorespiratory Adaptations: Elevated cardiac output, hemoglobin levels and increased capillarization.
  • Muscular Adaptations: Increased mitochondria, muscle mass, capillarization and glycogen storage.
  • Metabolic Adaptations: Higher glycolytic enzyme activity, elevated anaerobic threshold and more efficient fatty acid utilization.

5. Recovery

  • Phases: Re-plenishing myoglobin (1-5 days, dependent on exercise intensity and diet), energy regeneration (ATP and phosphocreatine), lactate clearance, and electrolyte balance.
  • Electrolyte Balance: Intake of isotonic sports drinks during recovery essential.

6. Physiological Effects of Training

  • Metabolic Adaptations: Increased oxidative capacity, utilization of free fatty acids, and reduced lactate production.
  • Cardiorespiratory Adaptations: Elevated cardiac output and hemoglobin levels.
  • Muscular Adaptations: Increased capillarization, mitochondria, and muscle mass, higher glycogen storage and glycolytic enzyme activity

7. Doping

  • Definition: Use of performance enhancing substances that have significant risks: including, stimulants, anabolic steroids, peptide hormones (EPO), beta-blockers, diuretics.
  • Methods Include: Blood doping, gene manipulation, and chemical alterations, and doping in animals.

8. Muscle Pain

  • Acute Pain: Caused by ischemia and metabolite buildup (e.g., lactate).
  • Delayed-Onset Muscle Soreness (DOMS): Results from structural damage to muscle fibers and an inflammatory response. Prevention includes gradual intensity increase.

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