Post-transcriptional regulation of eukaryotic genes expression

What is the complex formed from the association of each snRNA with core splicing proteins?

snRNP (correct)
snRNA
Core complex
Spliceosome

How many steps are involved in the assembly of the spliceosome?

6 (correct)
4
5
7

What is the function of SR proteins in splicing regulation?

To activate splicing (correct)
To inhibit intron definition
To cleave the 5' splice site
To form a bridge between U1 and U2AF

What is the mechanism by which U1 and SR proteins define the 5' splice region?

By forming a bridge with U2AF (C) Signup and view all the answers

What is the result of alternative splicing?

Increased protein diversity (C) Signup and view all the answers

What is the function of adenosine deaminase in RNA editing?

To convert adenosine to inosine (C) Signup and view all the answers

What is the result of RNA localization?

Pattern formation and fate specification (B) Signup and view all the answers

What is the mechanism of trans-splicing?

Exons from different mRNA molecules are joined together (A) Signup and view all the answers

What is the function of APOBEC1 in RNA editing?

To convert cytidine to uridine (A) Signup and view all the answers

What is the direction of external degradation of mRNA?

Both 3' to 5' and 5' to 3' (A) Signup and view all the answers

Which of the following best describes the interaction between U1 and SR proteins in splicing regulation?

U1 defines the 3' splice site, while SR proteins define the 5' splice region (C) Signup and view all the answers

What is the primary function of the spliceosome in eukaryotic gene expression?

To regulate the joining of exons to form mature mRNA (B) Signup and view all the answers

What is the outcome of the conversion of adenosine to inosine by adenosine deaminase during RNA editing?

The modification of the mRNA sequence (A) Signup and view all the answers

What is the primary function of hnRNPs in splicing regulation?

To inhibit intron definition interactions (D) Signup and view all the answers

What is the outcome of the assembly of high-order repressive complexes in splicing regulation?

The inhibition of exon definition interactions (C) Signup and view all the answers

What is the primary function of U2AF in splicing regulation?

To bind to the 3' splice site (B) Signup and view all the answers

What is the outcome of alternative splicing in eukaryotic gene expression?

The creation of protein diversity (B) Signup and view all the answers

What is the primary function of compartmentalization in RNA localization?

To specialize regions within a cell (B) Signup and view all the answers

What is the outcome of internal cleavage by endonucleases in RNA degradation?

The cleavage of mRNA at specific sites (A) Signup and view all the answers

What is the primary function of APOBEC1 in RNA editing?

To convert cytidine to uridine (C) Signup and view all the answers

What is the consequence of U1 + SR protein defining the 5' splice region?

Activation of splicing (C) Signup and view all the answers

What is the role of U2AF in the splicing process?

Recognition of the 3' splice site (A) Signup and view all the answers

What is the outcome of the conversion of cytidine to uridine by APOBEC1?

RNA editing (D) Signup and view all the answers

What is the mechanism by which U2AF and U1/SR protein interact?

Formation of a bridge between the 5' and 3' splice sites (B) Signup and view all the answers

What is the result of RNA degradation by exonucleases?

Complete degradation of the mRNA (B) Signup and view all the answers

What is the role of compartmentalization in RNA localization?

Localisation of mRNA to specific regions (B) Signup and view all the answers

What is the outcome of the assembly of the spliceosome?

Formation of a lariat (B) Signup and view all the answers

What is the role of hnRNPs in splicing regulation?

Inhibiting intron definition interactions (A) Signup and view all the answers

What is the consequence of trans-splicing?

Joining of exons from different mRNA molecules (C) Signup and view all the answers

What is the mechanism of internal cleavage by endonuclease?

Cleavage of the mRNA at a specific site (D) Signup and view all the answers