Post-transcriptional regulation of eukaryotic genes expression
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Questions and Answers

What is the complex formed from the association of each snRNA with core splicing proteins?

  • snRNP (correct)
  • snRNA
  • Core complex
  • Spliceosome

    • How many steps are involved in the assembly of the spliceosome?

  • 6 (correct)
  • 4
  • 5
  • 7

    • What is the function of SR proteins in splicing regulation?

  • To activate splicing (correct)
  • To inhibit intron definition
  • To cleave the 5' splice site
  • To form a bridge between U1 and U2AF

    • What is the mechanism by which U1 and SR proteins define the 5' splice region?

    <p>By forming a bridge with U2AF</p> Signup and view all the answers

    What is the result of alternative splicing?

    <p>Increased protein diversity</p> Signup and view all the answers

    What is the function of adenosine deaminase in RNA editing?

    <p>To convert adenosine to inosine</p> Signup and view all the answers

    What is the result of RNA localization?

    <p>Pattern formation and fate specification</p> Signup and view all the answers

    What is the mechanism of trans-splicing?

    <p>Exons from different mRNA molecules are joined together</p> Signup and view all the answers

    What is the function of APOBEC1 in RNA editing?

    <p>To convert cytidine to uridine</p> Signup and view all the answers

    What is the direction of external degradation of mRNA?

    <p>Both 3' to 5' and 5' to 3'</p> Signup and view all the answers

    Which of the following best describes the interaction between U1 and SR proteins in splicing regulation?

    <p>U1 defines the 3' splice site, while SR proteins define the 5' splice region</p> Signup and view all the answers

    What is the primary function of the spliceosome in eukaryotic gene expression?

    <p>To regulate the joining of exons to form mature mRNA</p> Signup and view all the answers

    What is the outcome of the conversion of adenosine to inosine by adenosine deaminase during RNA editing?

    <p>The modification of the mRNA sequence</p> Signup and view all the answers

    What is the primary function of hnRNPs in splicing regulation?

    <p>To inhibit intron definition interactions</p> Signup and view all the answers

    What is the outcome of the assembly of high-order repressive complexes in splicing regulation?

    <p>The inhibition of exon definition interactions</p> Signup and view all the answers

    What is the primary function of U2AF in splicing regulation?

    <p>To bind to the 3' splice site</p> Signup and view all the answers

    What is the outcome of alternative splicing in eukaryotic gene expression?

    <p>The creation of protein diversity</p> Signup and view all the answers

    What is the primary function of compartmentalization in RNA localization?

    <p>To specialize regions within a cell</p> Signup and view all the answers

    What is the outcome of internal cleavage by endonucleases in RNA degradation?

    <p>The cleavage of mRNA at specific sites</p> Signup and view all the answers

    What is the primary function of APOBEC1 in RNA editing?

    <p>To convert cytidine to uridine</p> Signup and view all the answers

    What is the consequence of U1 + SR protein defining the 5' splice region?

    <p>Activation of splicing</p> Signup and view all the answers

    What is the role of U2AF in the splicing process?

    <p>Recognition of the 3' splice site</p> Signup and view all the answers

    What is the outcome of the conversion of cytidine to uridine by APOBEC1?

    <p>RNA editing</p> Signup and view all the answers

    What is the mechanism by which U2AF and U1/SR protein interact?

    <p>Formation of a bridge between the 5' and 3' splice sites</p> Signup and view all the answers

    What is the result of RNA degradation by exonucleases?

    <p>Complete degradation of the mRNA</p> Signup and view all the answers

    What is the role of compartmentalization in RNA localization?

    <p>Localisation of mRNA to specific regions</p> Signup and view all the answers

    What is the outcome of the assembly of the spliceosome?

    <p>Formation of a lariat</p> Signup and view all the answers

    What is the role of hnRNPs in splicing regulation?

    <p>Inhibiting intron definition interactions</p> Signup and view all the answers

    What is the consequence of trans-splicing?

    <p>Joining of exons from different mRNA molecules</p> Signup and view all the answers

    What is the mechanism of internal cleavage by endonuclease?

    <p>Cleavage of the mRNA at a specific site</p> Signup and view all the answers

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