30 Questions
What is the complex formed from the association of each snRNA with core splicing proteins?
snRNP
How many steps are involved in the assembly of the spliceosome?
6
What is the function of SR proteins in splicing regulation?
To activate splicing
What is the mechanism by which U1 and SR proteins define the 5' splice region?
By forming a bridge with U2AF
What is the result of alternative splicing?
Increased protein diversity
What is the function of adenosine deaminase in RNA editing?
To convert adenosine to inosine
What is the result of RNA localization?
Pattern formation and fate specification
What is the mechanism of trans-splicing?
Exons from different mRNA molecules are joined together
What is the function of APOBEC1 in RNA editing?
To convert cytidine to uridine
What is the direction of external degradation of mRNA?
Both 3' to 5' and 5' to 3'
Which of the following best describes the interaction between U1 and SR proteins in splicing regulation?
U1 defines the 3' splice site, while SR proteins define the 5' splice region
What is the primary function of the spliceosome in eukaryotic gene expression?
To regulate the joining of exons to form mature mRNA
What is the outcome of the conversion of adenosine to inosine by adenosine deaminase during RNA editing?
The modification of the mRNA sequence
What is the primary function of hnRNPs in splicing regulation?
To inhibit intron definition interactions
What is the outcome of the assembly of high-order repressive complexes in splicing regulation?
The inhibition of exon definition interactions
What is the primary function of U2AF in splicing regulation?
To bind to the 3' splice site
What is the outcome of alternative splicing in eukaryotic gene expression?
The creation of protein diversity
What is the primary function of compartmentalization in RNA localization?
To specialize regions within a cell
What is the outcome of internal cleavage by endonucleases in RNA degradation?
The cleavage of mRNA at specific sites
What is the primary function of APOBEC1 in RNA editing?
To convert cytidine to uridine
What is the consequence of U1 + SR protein defining the 5' splice region?
Activation of splicing
What is the role of U2AF in the splicing process?
Recognition of the 3' splice site
What is the outcome of the conversion of cytidine to uridine by APOBEC1?
RNA editing
What is the mechanism by which U2AF and U1/SR protein interact?
Formation of a bridge between the 5' and 3' splice sites
What is the result of RNA degradation by exonucleases?
Complete degradation of the mRNA
What is the role of compartmentalization in RNA localization?
Localisation of mRNA to specific regions
What is the outcome of the assembly of the spliceosome?
Formation of a lariat
What is the role of hnRNPs in splicing regulation?
Inhibiting intron definition interactions
What is the consequence of trans-splicing?
Joining of exons from different mRNA molecules
What is the mechanism of internal cleavage by endonuclease?
Cleavage of the mRNA at a specific site
Test your knowledge on the regulation of eukaryotic gene expression, including the spliceosome assembly process and its various stages. Learn about the roles of small nuclear RNA and core splicing proteins in this crucial biological process.
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