Podcast
Questions and Answers
What regulates the amount of zinc in enterocytes?
What regulates the amount of zinc in enterocytes?
- Synthesis of metallothionein
- Intestinal lumen
- Metal binding protein
- Zinc transport proteins (correct)
How is the amount of zinc passing from the enterocyte into blood regulated?
How is the amount of zinc passing from the enterocyte into blood regulated?
- Intestinal lumen
- Synthesis of zinc transport proteins
- Metallothionein (correct)
- Storage vesicles
What happens when zinc levels are high?
What happens when zinc levels are high?
- Increased synthesis of metallothionein occurs (correct)
- Zinc is transported into the blood stream
- Zinc transport proteins are inhibited
- Zinc is stored in the enterocyte
What prevents zinc from moving into the bloodstream?
What prevents zinc from moving into the bloodstream?
When is zinc lost from the enterocyte?
When is zinc lost from the enterocyte?
What is the role of some zinc transport proteins?
What is the role of some zinc transport proteins?
What is the effect of high zinc intake on zinc transport?
What is the effect of high zinc intake on zinc transport?
What regulates the amount of zinc that passes into the blood?
What regulates the amount of zinc that passes into the blood?
What happens to zinc within vesicles?
What happens to zinc within vesicles?
What occurs when zinc levels are high?
What occurs when zinc levels are high?
Which mineral is involved in superoxide dismutase function, DNA and RNA synthesis, carbohydrate metabolism, insulin storage, and immune system function?
Which mineral is involved in superoxide dismutase function, DNA and RNA synthesis, carbohydrate metabolism, insulin storage, and immune system function?
What is a symptom of zinc deficiency?
What is a symptom of zinc deficiency?
Which mineral can cause copper deficiency when present in chronic toxicity?
Which mineral can cause copper deficiency when present in chronic toxicity?
What is a function of copper in the body?
What is a function of copper in the body?
What is a symptom of zinc toxicity?
What is a symptom of zinc toxicity?
Which mineral can decrease the bioavailability of copper?
Which mineral can decrease the bioavailability of copper?
What is a symptom of copper deficiency?
What is a symptom of copper deficiency?
What is a rare inherited form of zinc deficiency that rapidly responds to zinc supplementation?
What is a rare inherited form of zinc deficiency that rapidly responds to zinc supplementation?
Which mineral is involved in collagen cross-linking, iron metabolism, and antioxidant protection?
Which mineral is involved in collagen cross-linking, iron metabolism, and antioxidant protection?
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Study Notes
Essential Minerals and Their Functions in the Body
- Under low zinc intake, more zinc is transported into the enterocyte than out, leading to reduced metallothionein production and increased Zn in the blood.
- Zinc is involved in superoxide dismutase function, DNA and RNA synthesis, carbohydrate metabolism, insulin storage, and immune system function.
- Zinc fingers, required for DNA binding, are influenced by zinc intake.
- Acrodermatits enteropathica is a rare inherited form of zinc deficiency that rapidly responds to zinc supplementation.
- Zinc deficiency symptoms include poor growth, skin rashes, hair loss, and reduced immune function.
- Zinc toxicity can cause gastrointestinal irritation, headaches, and chronic zinc toxicity can lead to copper deficiency.
- Copper exists in +1 and +2 oxidation states, with the majority in the CuII form, and zinc can decrease the bioavailability of copper.
- Copper functions in the body include electron transport, collagen cross-linking, iron metabolism, neurotransmitter production, melanin production, and antioxidant protection.
- Copper absorption is about 30-40% and can be inhibited by high intakes of iron, manganese, molybdenum, and vitamin C.
- Copper deficiency can occur in infants with chronic diarrhea, patients undergoing chronic dialysis, and individuals with genetic disorders like Menkes disease.
- Wilson’s disease is a rare genetic disorder resulting in copper overload, characterized by Kayser-Fleischer rings in the eyes.
- Manganese is involved in various metabolic processes, including amino acid, cholesterol, and cartilage metabolism, and is also needed for the activity of superoxide dismutase.
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