Podcast
Questions and Answers
What is the therapeutic class of esomeprazole (Nexium)?
What is the therapeutic class of esomeprazole (Nexium)?
- Antacids
- Antiulcer Agents (correct)
- Proton Pump Inhibitors
- Antibiotics
What is the pharmacologic class of esomeprazole (Nexium)?
What is the pharmacologic class of esomeprazole (Nexium)?
- H2 Blockers
- Prostaglandin Analogs
- Proton Pump Inhibitors (correct)
- Antacids
What is one indication for the use of esomeprazole (Nexium)?
What is one indication for the use of esomeprazole (Nexium)?
- GERD (correct)
- Heart failure
- Hypertension
- Asthma
What is the mechanism of action of esomeprazole (Nexium)?
What is the mechanism of action of esomeprazole (Nexium)?
What are common side effects of esomeprazole (Nexium)?
What are common side effects of esomeprazole (Nexium)?
Esomeprazole (Nexium) may cause a deficiency in vitamin ______.
Esomeprazole (Nexium) may cause a deficiency in vitamin ______.
What is the adult dosage for GERD when taking esomeprazole (Nexium)?
What is the adult dosage for GERD when taking esomeprazole (Nexium)?
What should be monitored when a patient is on esomeprazole (Nexium) for more than 3 months?
What should be monitored when a patient is on esomeprazole (Nexium) for more than 3 months?
When should esomeprazole (Nexium) be taken?
When should esomeprazole (Nexium) be taken?
Which of the following should be avoided when taking esomeprazole (Nexium)?
Which of the following should be avoided when taking esomeprazole (Nexium)?
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Study Notes
Esomeprazole (Nexium) Overview
- Therapeutic class: Antiulcer agents
- Pharmacologic class: Proton pump inhibitors
Indications and Uses
- Treatment for GERD (Gastroesophageal reflux disease) and erosive esophagitis
- Addresses bleeding gastric or duodenal ulcers
- Reduces risk of gastric ulcers associated with NSAID usage
- Used in combination with amoxicillin to eradicate H. pylori infection
Mechanism of Action
- Inhibits hydrogen ion transport by binding to an enzyme on gastric parietal cells
- Action occurs in an acidic gastric environment, leading to decreased stomach acid production
Therapeutic Effects
- Reduces gastric acidity
- Promotes healing of duodenal ulcers
- Lowers incidence of gastric ulcers caused by NSAIDs
Side Effects
- Common gastrointestinal issues: Clostridium difficile-associated diarrhea (CDAD), constipation, diarrhea, dry mouth
- Hematological: Potential vitamin B12 deficiency
- Musculoskeletal: Risk of bone fractures
- Electrolyte imbalance: Hypomagnesemia with prolonged treatment (≥3 months)
Adult Dosage Parameters
- GERD: 20-40 mg orally daily for 4-8 weeks
- Eradication of H. pylori: 40 mg orally for 10 days
- Intravenous administration: 5 ml normal saline over 3 minutes
Nursing Interventions
- Monitor for gastrointestinal bleeding (blood in stools)
- Assess for signs of hypomagnesemia (e.g., seizures, irregular heartbeat)
- Antacids may be administered alongside esomeprazole
- Advise patients to take medication 1 hour before meals
- Discuss pregnancy implications and contraindications
- Instruct patients to avoid alcohol, aspirin, and NSAIDs
Administration and Monitoring
- Best taken on an empty stomach, 1 hour before meals or other medications
- Administered undiluted via IV over 2 minutes
- Monitor liver enzyme levels routinely
- Advise patients to report symptoms like abdominal pain, diarrhea, or black/tarry stools immediately
- Encourage adequate intake of calcium and vitamin D to support bone health
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