Podcast
Questions and Answers
What is the generic name of Nexium?
What is the generic name of Nexium?
Esomeprazole magnesium
What class of drug is Nexium?
What class of drug is Nexium?
Gastric antisecretory
Name the dosage forms of Nexium.
Name the dosage forms of Nexium.
Capsules, delayed-release: 20 and 40 mg; Granules for oral suspension: 10, 20, 40 mg; Powder for injection, freeze dried: 20, 40 mg in single dose vials
What are some indications for the use of Nexium? (Select all that apply)
What are some indications for the use of Nexium? (Select all that apply)
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What is the normal oral starting dose for Nexium?
What is the normal oral starting dose for Nexium?
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What is the dosing for GERD using Nexium?
What is the dosing for GERD using Nexium?
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What is the dosing for erosive esophagitis and gastric ulcer healing maintenance with Nexium?
What is the dosing for erosive esophagitis and gastric ulcer healing maintenance with Nexium?
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How is Nexium dosed for H.pylori treatment?
How is Nexium dosed for H.pylori treatment?
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What is the dosing for reduction in gastric ulcer occurrence using Nexium?
What is the dosing for reduction in gastric ulcer occurrence using Nexium?
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What is the dosing for short-term treatment of GERD when oral therapy is not appropriate?
What is the dosing for short-term treatment of GERD when oral therapy is not appropriate?
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What is the dosing for pathological hypersecretory conditions with Nexium?
What is the dosing for pathological hypersecretory conditions with Nexium?
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What is the mechanism of action of Nexium?
What is the mechanism of action of Nexium?
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What is the peak plasma level time for Nexium?
What is the peak plasma level time for Nexium?
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What is the terminal elimination half-life of Nexium?
What is the terminal elimination half-life of Nexium?
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How is Nexium metabolized?
How is Nexium metabolized?
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What are some drug interactions with Nexium? (Select all that apply)
What are some drug interactions with Nexium? (Select all that apply)
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Which of the following are contraindications/precautions of Nexium? (Select all that apply)
Which of the following are contraindications/precautions of Nexium? (Select all that apply)
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What are some common adverse effects of Nexium? (Select all that apply)
What are some common adverse effects of Nexium? (Select all that apply)
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When should Nexium be taken in relation to eating?
When should Nexium be taken in relation to eating?
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What should patients do if they miss a dose of Nexium?
What should patients do if they miss a dose of Nexium?
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Study Notes
Nexium Overview
- Generic name: Esomeprazole magnesium
- Drug class: Gastric antisecretory
Dosage Forms
- Capsules: Delayed-release available in 20 mg and 40 mg
- Granules for oral suspension: 10 mg, 20 mg, and 40 mg
- Powder for injection: Freeze-dried, 20 mg and 40 mg in single-dose vials
Indications
- Short-term treatment of erosive esophagitis
- Management of symptomatic gastroesophageal reflux disease (GERD)
- Adjunctive use in triple therapy for H. pylori infection
- Reduction of gastric ulcers
- Treatment of pathological hypersecretory conditions (Zollinger-Ellison Syndrome)
Dosing Information
- Normal oral starting dose: 20-40 mg daily for 4-8 weeks
- GERD dosing: 20 mg daily for 4-8 weeks
- Erosive esophagitis and gastric ulcer maintenance: 20 mg daily for 4-8 weeks
- H. pylori treatment: 40 mg daily with 500 mg clarithromycin and 1000 mg amoxicillin twice daily for 10 days
- Gastric ulcer occurrence reduction: 20-40 mg once daily for up to 6 months
- Short-term GERD treatment via IV: 20-40 mg administered over at least 3 minutes or as a continuous infusion over 10-30 minutes
- Pathological hypersecretory conditions: 40 mg twice a day
Mechanism of Action
- Proton pump inhibitor that suppresses the H+/K+ ATPase enzyme system in gastric parietal cells, blocking the final step of acid production.
Pharmacokinetics
- Peak plasma level: Achieved in approximately 1.5 hours
- Terminal elimination half-life: Also 1.5 hours
- Metabolism: Primarily via CYP2C19 isoenzyme, with some metabolism by CYP3A4 isoenzyme
Drug Interactions
- Drugs requiring gastric pH may have impaired absorption (e.g., ketoconazole, digoxin)
- Increases plasma levels of diazepam
- Decreases plasma levels of atazanavir
- Inhibits metabolism of cilostazole
Contraindications and Precautions
- Long-term use may increase the risk of gastric carcinoid tumors
- Rare severe dermatologic reactions (e.g., toxic epidermal necrolysis)
- Classified as Pregnancy category B
Adverse Effects
- Common side effects include headache, diarrhea, constipation, nausea, gas, abdominal pain, and dry mouth
Patient Consultation Points
- Take at least 1 hour prior to eating
- Swallow capsules whole or sprinkle enteric-coated granules on applesauce and swallow immediately
- Mix granules with 15 mL of water, stir, let sit for 3 minutes, take within 30 minutes of mixing
- Antacids can be taken concurrently
- Store in a cool, dry place
- If a dose is missed, take as soon as possible or skip if near the next dose
- Do NOT double doses
- Contact a physician for persistent side effects
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Description
Test your knowledge about Nexium, including its generic name, drug class, dosage forms, and indications. This quiz aims to help you understand essential details regarding this medication.
