Nexium Flashcards

Questions and Answers

What is the generic name of Nexium?

Esomeprazole magnesium

What class of drug is Nexium?

Gastric antisecretory

Name the dosage forms of Nexium.

Capsules, delayed-release: 20 and 40 mg; Granules for oral suspension: 10, 20, 40 mg; Powder for injection, freeze dried: 20, 40 mg in single dose vials

What are some indications for the use of Nexium? (Select all that apply)

Reduction of gastric ulcers Signup and view all the answers

What is the normal oral starting dose for Nexium?

20-40 mg daily for 4-8 weeks Signup and view all the answers

What is the dosing for GERD using Nexium?

20 mg daily for 4-8 weeks Signup and view all the answers

What is the dosing for erosive esophagitis and gastric ulcer healing maintenance with Nexium?

20 mg daily for 4-8 weeks Signup and view all the answers

How is Nexium dosed for H.pylori treatment?

40 mg once daily with clarithromycin and amoxicillin Signup and view all the answers

What is the dosing for reduction in gastric ulcer occurrence using Nexium?

20-40 mg once daily for up to 6 months Signup and view all the answers

What is the dosing for short-term treatment of GERD when oral therapy is not appropriate?

(IV) 20-40 mg over at least 3 minutes Signup and view all the answers

What is the dosing for pathological hypersecretory conditions with Nexium?

40 mg twice a day Signup and view all the answers

What is the mechanism of action of Nexium?

It is a proton pump inhibitor that suppresses the H+/K+ ATPase enzyme system. Signup and view all the answers

What is the peak plasma level time for Nexium?

1.5 hours Signup and view all the answers

What is the terminal elimination half-life of Nexium?

1.5 hours Signup and view all the answers

How is Nexium metabolized?

Via the CYP2C19 isoenzyme and the remaining by the CYP3A4 isoenzyme. Signup and view all the answers

What are some drug interactions with Nexium? (Select all that apply)

Increases plasma levels of diazepam Signup and view all the answers

Which of the following are contraindications/precautions of Nexium? (Select all that apply)

Severe dermatologic reactions Signup and view all the answers

What are some common adverse effects of Nexium? (Select all that apply)

Nausea Signup and view all the answers

When should Nexium be taken in relation to eating?

At least 1 hour prior to eating Signup and view all the answers

What should patients do if they miss a dose of Nexium?

Take ASAP if closer to the next dose Signup and view all the answers

Study Notes

Nexium Overview

Generic name: Esomeprazole magnesium
Drug class: Gastric antisecretory

Dosage Forms

Capsules: Delayed-release available in 20 mg and 40 mg
Granules for oral suspension: 10 mg, 20 mg, and 40 mg
Powder for injection: Freeze-dried, 20 mg and 40 mg in single-dose vials

Indications

Short-term treatment of erosive esophagitis
Management of symptomatic gastroesophageal reflux disease (GERD)
Adjunctive use in triple therapy for H. pylori infection
Reduction of gastric ulcers
Treatment of pathological hypersecretory conditions (Zollinger-Ellison Syndrome)

Dosing Information

Normal oral starting dose: 20-40 mg daily for 4-8 weeks
GERD dosing: 20 mg daily for 4-8 weeks
Erosive esophagitis and gastric ulcer maintenance: 20 mg daily for 4-8 weeks
H. pylori treatment: 40 mg daily with 500 mg clarithromycin and 1000 mg amoxicillin twice daily for 10 days
Gastric ulcer occurrence reduction: 20-40 mg once daily for up to 6 months
Short-term GERD treatment via IV: 20-40 mg administered over at least 3 minutes or as a continuous infusion over 10-30 minutes
Pathological hypersecretory conditions: 40 mg twice a day

Mechanism of Action

Proton pump inhibitor that suppresses the H+/K+ ATPase enzyme system in gastric parietal cells, blocking the final step of acid production.

Pharmacokinetics

Peak plasma level: Achieved in approximately 1.5 hours
Terminal elimination half-life: Also 1.5 hours
Metabolism: Primarily via CYP2C19 isoenzyme, with some metabolism by CYP3A4 isoenzyme

Drug Interactions

Drugs requiring gastric pH may have impaired absorption (e.g., ketoconazole, digoxin)
Increases plasma levels of diazepam
Decreases plasma levels of atazanavir
Inhibits metabolism of cilostazole

Contraindications and Precautions

Long-term use may increase the risk of gastric carcinoid tumors
Rare severe dermatologic reactions (e.g., toxic epidermal necrolysis)
Classified as Pregnancy category B

Adverse Effects

Common side effects include headache, diarrhea, constipation, nausea, gas, abdominal pain, and dry mouth

Patient Consultation Points

Take at least 1 hour prior to eating
Swallow capsules whole or sprinkle enteric-coated granules on applesauce and swallow immediately
Mix granules with 15 mL of water, stir, let sit for 3 minutes, take within 30 minutes of mixing
Antacids can be taken concurrently
Store in a cool, dry place
If a dose is missed, take as soon as possible or skip if near the next dose
Do NOT double doses
Contact a physician for persistent side effects

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Description

Test your knowledge about Nexium, including its generic name, drug class, dosage forms, and indications. This quiz aims to help you understand essential details regarding this medication.