Podcast
Questions and Answers
What is the primary receptor on a red blood cell's surface that is targeted by merozoites?
What is the primary receptor on a red blood cell's surface that is targeted by merozoites?
- Integrin
- Cadherin
- Selectin
- Glycophorin (correct)
What structure is formed inside the red blood cell once a merozoite enters?
What structure is formed inside the red blood cell once a merozoite enters?
- Parasitophorous vacuole (correct)
- Mitochondrial matrix
- Endoplasmic reticulum
- Lysosome
Which form of the parasite is described as having a signet ring or annular appearance?
Which form of the parasite is described as having a signet ring or annular appearance?
- Schizont
- Ring form (correct)
- Merozoite
- Trophozoite
What is the prepatent period?
What is the prepatent period?
The ring form of the parasite typically occupies how much of the red blood cell, with the exception of P. falciparum?
The ring form of the parasite typically occupies how much of the red blood cell, with the exception of P. falciparum?
Which Plasmodium species exhibits the shortest duration of pre-erythrocytic schizogony?
Which Plasmodium species exhibits the shortest duration of pre-erythrocytic schizogony?
A patient is experiencing a relapse of malaria symptoms one year after apparent successful treatment. Which Plasmodium species is most likely the cause?
A patient is experiencing a relapse of malaria symptoms one year after apparent successful treatment. Which Plasmodium species is most likely the cause?
The size of the pre-erythrocytic schizont is largest in which of the following Plasmodium species?
The size of the pre-erythrocytic schizont is largest in which of the following Plasmodium species?
Which statement best describes the current understanding of malarial relapse?
Which statement best describes the current understanding of malarial relapse?
Which of the following is a key feature of recrudescence of a Plasmodium falciparum infection?
Which of the following is a key feature of recrudescence of a Plasmodium falciparum infection?
Flashcards
Erythrocytic schizogony
Erythrocytic schizogony
The process where merozoites invade RBCs and multiply through asexual reproduction.
Merozoite
Merozoite
A form of malaria parasite that binds to RBCs to enter them via endocytosis.
Trophozoite
Trophozoite
The stage of the malaria parasite after the merozoite transforms, losing organelles.
Ring form
Ring form
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Prepatent period
Prepatent period
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Pre-erythrocytic schizogony duration
Pre-erythrocytic schizogony duration
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Merozoites per schizont
Merozoites per schizont
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Hypnozoites
Hypnozoites
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Relapse vs. recrudescence
Relapse vs. recrudescence
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Malarial relapse timing
Malarial relapse timing
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Study Notes
Erythrocytic Schizogony
- Hepatic merozoites, released from pre-erythrocytic schizonts, invade red blood cells (RBCs).
- Merozoites attach to glycophorin receptors on RBC surfaces, entering via endocytosis and residing within a parasitophorous vacuole.
- This invasion process takes approximately 30 seconds.
- Merozoites transform into trophozoites, losing their internal organelles and becoming rounded.
- Early trophozoites are ring-shaped, appearing annular or as a signet ring.
- These ring forms contain a central vacuole and a thin peripheral cytoplasm with a nucleus.
- Ring forms usually occupy about one-third of the RBC, except in P. falciparum where they occupy only about one-sixth.
- Ring forms are the first detectable asexual forms in the peripheral blood.
- The period between the parasite's entry into a human and its detection in peripheral blood is the prepatent period.
- The duration of pre-erythrocytic schizogony varies between different Plasmodium species, ranging from 5.5 days for P. falciparum to 15 days for P. malariae.
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