Erythrocytic Differentiation and Red Blood Cell Proteins

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Which of the following proteins is responsible for the exchange of chloride and bicarbonate ions during the transport of CO2 from the tissues back to the lungs?

Rh protein
Ca2+ATPase
Band 3 (correct)
Na+/K+ATPase

Which of the following is a peripheral protein that forms the horizontal lattice or interaction and is important in maintaining the biconcave shape of the RBC?

Transferrin
Glycophorin
Glucose transporter
α spectrin (correct)

What is the function of the Ii blood group antigens?

They are involved in the transport of CO2 from the tissues back to the lungs
They are a type of enzyme regulator
They are a type of glucose transporter
They are carried on the carbohydrate component of the RBC band 3 protein (correct)

Which of the following proteins is NOT a major binding site for a variety of enzymes and cytoplasmic membrane components?

Glycophorin (B) Signup and view all the answers

What is the function of Decay-accelerating factor (DAF)?

It is an enzyme involved in the breakdown of urea (D) Signup and view all the answers

What is the primary characteristic of absolute anemia?

Red cell mass is decreased (B) Signup and view all the answers

Which of the following proteins is found in BFU-E and serves as a lineage specific marker of erythrocytic differentiation?

Glycophorin (A) Signup and view all the answers

What is the primary advantage of morphologic classification of anemia?

It is simple and based on readily available RBC indices (C) Signup and view all the answers

What is the primary function of hemoglobin in erythrocytes?

Transporting oxygen from the lungs to tissues and facilitating CO2 transportation to the lungs (B) Signup and view all the answers

Which of the following is NOT a type of anemia that can be classified as normocytic?

Iron deficiency anemia (C) Signup and view all the answers

Which type of anemia classification is best suited for relating disease processes to potential causes?

Pathophysiologic classification (C) Signup and view all the answers

What is the primary mechanism of removal of senescent red cells in the body?

Extravascular removal by macrophages (B) Signup and view all the answers

What is the effect of increased red cell mass or Hb on EPO drive?

It reduces EPO drive due to increased oxygen supply to tissues (A) Signup and view all the answers

What is the primary mechanism by which EPO gene is stimulated?

Through the stimulation of hypoxia response element by hypoxia inducible factor (HIF) (D) Signup and view all the answers

What is a common cause of microcytic hypochromic anemia?

Iron deficiency (C) Signup and view all the answers

Which of the following is an example of an extrinsic or extracorpuscular defect leading to hemolytic anemia?

Warm-type autoimmune hemolytic anemia (C) Signup and view all the answers

What is the typical lifespan of red blood cells in normal individuals?

120 days (B) Signup and view all the answers

What is the consequence of expansion of erythropoiesis into fatty marrow in chronic states?

It results in bone deformities, including frontal skull bossing (C) Signup and view all the answers

What is the clinical implication of recombinant EPO?

It is used to treat anemia from renal disease or other causes (C) Signup and view all the answers

Which of the following is NOT a hereditary hemolytic anemia?

Warm-type autoimmune hemolytic anemia (C) Signup and view all the answers

Which of the following is an example of a hemolytic anemia due to membrane lipid disorders?

Hereditary abetalipoproteinemia (A) Signup and view all the answers

What is the approximate concentration of hemoglobin in the blood?

15g/dl (A) Signup and view all the answers

What is the primary difference between hereditary and acquired hemolytic anemias?

Hereditary anemias are due to intrinsic red cell defects, while acquired anemias are due to extrinsic defects (B) Signup and view all the answers

What is the outcome if decay accelerating factor is absent?

Failure to inactivate complement and increased cell lysis (A) Signup and view all the answers

What is the purpose of the Coombs Test – Direct?

To look for immunoglobulin and/or complement on the surface of red blood cells (A) Signup and view all the answers

What is the typical amount of iron in the adult human body?

50 mg/kg in males and 40 mg/kg in females (B) Signup and view all the answers

What is the purpose of the Coombs Test – Indirect?

To detect anti-red blood cell antibodies in the patient's serum (C) Signup and view all the answers

What is the consequence of hemolysis?

Increased indirect bilirubin and increased LDH (A) Signup and view all the answers

What is the goal of treatment for hemolytic anemia?

To remove the underlying cause (D) Signup and view all the answers