Erythrocytic Differentiation and Red Blood Cell Proteins
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Questions and Answers

Which of the following proteins is responsible for the exchange of chloride and bicarbonate ions during the transport of CO2 from the tissues back to the lungs?

  • Rh protein
  • Ca2+ATPase
  • Band 3 (correct)
  • Na+/K+ATPase

    • Which of the following is a peripheral protein that forms the horizontal lattice or interaction and is important in maintaining the biconcave shape of the RBC?

  • Transferrin
  • Glycophorin
  • Glucose transporter
  • α spectrin (correct)

    • What is the function of the Ii blood group antigens?

  • They are involved in the transport of CO2 from the tissues back to the lungs
  • They are a type of enzyme regulator
  • They are a type of glucose transporter
  • They are carried on the carbohydrate component of the RBC band 3 protein (correct)

    • Which of the following proteins is NOT a major binding site for a variety of enzymes and cytoplasmic membrane components?

    <p>Glycophorin</p> Signup and view all the answers

    What is the function of Decay-accelerating factor (DAF)?

    <p>It is an enzyme involved in the breakdown of urea</p> Signup and view all the answers

    What is the primary characteristic of absolute anemia?

    <p>Red cell mass is decreased</p> Signup and view all the answers

    Which of the following proteins is found in BFU-E and serves as a lineage specific marker of erythrocytic differentiation?

    <p>Glycophorin</p> Signup and view all the answers

    What is the primary advantage of morphologic classification of anemia?

    <p>It is simple and based on readily available RBC indices</p> Signup and view all the answers

    What is the primary function of hemoglobin in erythrocytes?

    <p>Transporting oxygen from the lungs to tissues and facilitating CO2 transportation to the lungs</p> Signup and view all the answers

    Which of the following is NOT a type of anemia that can be classified as normocytic?

    <p>Iron deficiency anemia</p> Signup and view all the answers

    Which type of anemia classification is best suited for relating disease processes to potential causes?

    <p>Pathophysiologic classification</p> Signup and view all the answers

    What is the primary mechanism of removal of senescent red cells in the body?

    <p>Extravascular removal by macrophages</p> Signup and view all the answers

    What is the effect of increased red cell mass or Hb on EPO drive?

    <p>It reduces EPO drive due to increased oxygen supply to tissues</p> Signup and view all the answers

    What is the primary mechanism by which EPO gene is stimulated?

    <p>Through the stimulation of hypoxia response element by hypoxia inducible factor (HIF)</p> Signup and view all the answers

    What is a common cause of microcytic hypochromic anemia?

    <p>Iron deficiency</p> Signup and view all the answers

    Which of the following is an example of an extrinsic or extracorpuscular defect leading to hemolytic anemia?

    <p>Warm-type autoimmune hemolytic anemia</p> Signup and view all the answers

    What is the typical lifespan of red blood cells in normal individuals?

    <p>120 days</p> Signup and view all the answers

    What is the consequence of expansion of erythropoiesis into fatty marrow in chronic states?

    <p>It results in bone deformities, including frontal skull bossing</p> Signup and view all the answers

    What is the clinical implication of recombinant EPO?

    <p>It is used to treat anemia from renal disease or other causes</p> Signup and view all the answers

    Which of the following is NOT a hereditary hemolytic anemia?

    <p>Warm-type autoimmune hemolytic anemia</p> Signup and view all the answers

    Which of the following is an example of a hemolytic anemia due to membrane lipid disorders?

    <p>Hereditary abetalipoproteinemia</p> Signup and view all the answers

    What is the approximate concentration of hemoglobin in the blood?

    <p>15g/dl</p> Signup and view all the answers

    What is the primary difference between hereditary and acquired hemolytic anemias?

    <p>Hereditary anemias are due to intrinsic red cell defects, while acquired anemias are due to extrinsic defects</p> Signup and view all the answers

    What is the outcome if decay accelerating factor is absent?

    <p>Failure to inactivate complement and increased cell lysis</p> Signup and view all the answers

    What is the purpose of the Coombs Test – Direct?

    <p>To look for immunoglobulin and/or complement on the surface of red blood cells</p> Signup and view all the answers

    What is the typical amount of iron in the adult human body?

    <p>50 mg/kg in males and 40 mg/kg in females</p> Signup and view all the answers

    What is the purpose of the Coombs Test – Indirect?

    <p>To detect anti-red blood cell antibodies in the patient's serum</p> Signup and view all the answers

    What is the consequence of hemolysis?

    <p>Increased indirect bilirubin and increased LDH</p> Signup and view all the answers

    What is the goal of treatment for hemolytic anemia?

    <p>To remove the underlying cause</p> Signup and view all the answers

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