Ergot Derivatives: Migraine & Hemorrhage

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Questions and Answers

What is the primary mechanism of action of ergot derivatives in treating migraines?

  • Increasing blood flow to the brain
  • Blocking pain receptors in the brain
  • Dilating peripheral blood vessels
  • Constricting cranial blood vessels (correct)

Which of the following is a common indication for ergot derivatives?

  • Preventing vascular headaches (correct)
  • Treating hypotension
  • Lowering cholesterol
  • Preventing blood clots

Which of the following conditions is a contraindication for using ergot derivatives?

  • Asthma
  • Diabetes
  • Hypotension
  • Coronary artery disease (CAD) (correct)

What is a potential adverse effect associated with ergot derivative medications?

<p>GI effects (C)</p> Signup and view all the answers

Which medication class has a potential drug-drug interaction with ergot derivatives?

<p>Triptans and beta blockers (D)</p> Signup and view all the answers

Which ergot derivative is indicated for uterine hemorrhage?

<p>Methergine (D)</p> Signup and view all the answers

Which of the following is a brand/generic name of an ergot derivative?

<p>Dihydroergotamine (B)</p> Signup and view all the answers

True or False: Ergotamine is FDA indicated for treatment of migraines.

<p>True (B)</p> Signup and view all the answers

Which of the following is NOT a contraindication of ergot derivatives?

<p>Arthritis (D)</p> Signup and view all the answers

What is a possible adverse effect of ergot derivatives related to blood flow?

<p>Ergotism (D)</p> Signup and view all the answers

Flashcards

Ergot Derivative: Mechanism of Action

Constricts cranial blood vessels, reducing pulsation of cranial arteries and hyperperfusion in the basilar artery.

Ergot Derivative Names

Dihydroergotamine, ergotamine

Ergot Derivative: Indications

Prevention or abortion of migraine or vascular headaches.

Ergot Derivative: Contraindications

CAD, hypertension, peripheral vascular disease, impaired liver function, pregnancy, or lactation.

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Ergot Derivative: Adverse Effects

CNS, CV, and GI effects, plus ergotism

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Ergot Derivative: Drug-Drug Interactions

Beta-blockers, triptans

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Methergine (OBGYN)

Used for uterine hemorrhage, but studies show efficacy for migraines (not FDA-indicated).

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Ergotism

A condition caused by ergot poisoning, leading to vasoconstriction and potentially gangrene.

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Study Notes

  • Ergot derivatives constrict cranial blood vessels.
  • They reduce pulsation of cranial arteries.
  • They reduce hyperperfusion of the basilar artery vascular bed.
  • Methergine is indicated for uterine hemorrhage.
  • Methergine is not FDA indicated for migraine treatment, but studies show efficacy.
  • Dihydroergotamine and ergotamine are ergot derivative drugs.
  • Ergot derivatives are indicated for prevention or abortion of migraine or vascular headaches.
  • Contraindications include CAD, hypertension, peripheral vascular disease, impaired liver function, pregnancy, or lactation.
  • Adverse effects include CNS effects, cardiovascular effects, GI effects, and ergotism.
  • Drug interactions occur with beta-blockers and triptans.

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