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Questions and Answers
What is the primary action of triptans in treating migraines?
What is the primary action of triptans in treating migraines?
What adverse effect is commonly associated with ergotamine?
What adverse effect is commonly associated with ergotamine?
Which of the following describes the primary function of CGRP inhibitors?
Which of the following describes the primary function of CGRP inhibitors?
Which side effect is reported with almotriptan compared to other triptans?
Which side effect is reported with almotriptan compared to other triptans?
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The primary concern of using triptans is associated with which cardiovascular effect?
The primary concern of using triptans is associated with which cardiovascular effect?
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What distinguishes ergot derivatives from triptans in migraine treatment?
What distinguishes ergot derivatives from triptans in migraine treatment?
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What CNS effect is common with CGRP inhibitors like eptinezumab?
What CNS effect is common with CGRP inhibitors like eptinezumab?
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Which of the following describes a gastrointestinal effect associated with triptans?
Which of the following describes a gastrointestinal effect associated with triptans?
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What is a common CNS effect associated with ergot derivatives in migraine treatment?
What is a common CNS effect associated with ergot derivatives in migraine treatment?
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What is a reported gastrointestinal side effect of triptans?
What is a reported gastrointestinal side effect of triptans?
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Which ergot derivative is commonly used for migraine relief?
Which ergot derivative is commonly used for migraine relief?
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Which of the following side effects is unique to the use of calcitonin?
Which of the following side effects is unique to the use of calcitonin?
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What is a significant cardiovascular effect of triptans?
What is a significant cardiovascular effect of triptans?
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What is the mechanism by which triptans alleviate migraine pain?
What is the mechanism by which triptans alleviate migraine pain?
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Almotriptan is reported to have which benefit compared to other triptans?
Almotriptan is reported to have which benefit compared to other triptans?
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What vasodilator chemical do CGRP inhibitors target during migraine attacks?
What vasodilator chemical do CGRP inhibitors target during migraine attacks?
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What is the primary mechanism of action of ergot derivatives in treating migraines?
What is the primary mechanism of action of ergot derivatives in treating migraines?
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Which side effect is most commonly associated with triptans?
Which side effect is most commonly associated with triptans?
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What is a characteristic effect of CNS stimulation from ergot derivatives?
What is a characteristic effect of CNS stimulation from ergot derivatives?
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Which of the following describes a common gastrointestinal effect associated with ergots?
Which of the following describes a common gastrointestinal effect associated with ergots?
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How do CGRP inhibitors function in alleviating migraines?
How do CGRP inhibitors function in alleviating migraines?
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What differentiates almotriptan from other triptans?
What differentiates almotriptan from other triptans?
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What effect does sumatriptan primarily have on cranial blood vessels?
What effect does sumatriptan primarily have on cranial blood vessels?
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Which side effect is commonly associated with calcitonin usage?
Which side effect is commonly associated with calcitonin usage?
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Which of the following effects is commonly associated with ergot derivatives in migraine treatment?
Which of the following effects is commonly associated with ergot derivatives in migraine treatment?
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What is a notable side effect of triptans such as almotriptan?
What is a notable side effect of triptans such as almotriptan?
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Which mechanism do CGRP inhibitors utilize to alleviate migraine symptoms?
Which mechanism do CGRP inhibitors utilize to alleviate migraine symptoms?
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What CNS effect is frequently reported with the use of ergotamine?
What CNS effect is frequently reported with the use of ergotamine?
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What distinguishes eptinezumab among migraine treatments?
What distinguishes eptinezumab among migraine treatments?
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Which gastrointestinal effect is associated with triptan medications?
Which gastrointestinal effect is associated with triptan medications?
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Which option best describes a potential adverse effect of triptans?
Which option best describes a potential adverse effect of triptans?
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What effect do ergot derivatives have on serotonin receptors?
What effect do ergot derivatives have on serotonin receptors?
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What is a potential central nervous system effect reported with the use of ergotamine?
What is a potential central nervous system effect reported with the use of ergotamine?
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Which serious cardiovascular effect is associated with the use of triptans?
Which serious cardiovascular effect is associated with the use of triptans?
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Which gastrointestinal effect is associated with triptans?
Which gastrointestinal effect is associated with triptans?
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What type of receptor sites do ergot derivatives block to relieve migraine pain?
What type of receptor sites do ergot derivatives block to relieve migraine pain?
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Which side effect is reported to be less common with almotriptan compared to other triptans?
Which side effect is reported to be less common with almotriptan compared to other triptans?
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What effect do CGRP inhibitors primarily target during a migraine?
What effect do CGRP inhibitors primarily target during a migraine?
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What is one of the known CNS effects of Lasmiditan?
What is one of the known CNS effects of Lasmiditan?
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What is a marked side effect of ergotism related to ergot derivative usage?
What is a marked side effect of ergotism related to ergot derivative usage?
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Study Notes
Ergot Derivatives
- Block alpha-adrenergic and serotonin receptors in the brain, constricting cranial vessels, decreasing cranial artery pulsation and basilar artery hyperperfusion.
- CNS effects include dizziness, vertigo, tingling sensation (warm), and hypertension; GI effects include abdominal pain and nausea.
- Examples include ergotamine (Ergomar) and sumatriptan (Imitrex).
Triptans
- Bind to selective serotonin receptors in cranial vessels, causing vasoconstriction.
- CNS effects encompass drowsiness, headache, and paresthesia; GI effects include dry mouth, nausea, and abdominal pain. Cardiovascular effects may include coronary artery vasospasm, MI, and ventricular arrhythmias.
- Examples include almotriptan, eletriptan (Relpax).
Calcitonin Gene-Related Peptide (CGRP) Inhibitors and Serotonin Agonists
- CGRP inhibitors like CGRP block a potent vasodilator chemical released during migraine headaches.
- Serotonin agonists have selective action on specific serotonin receptors.
- Possible side effects include dizziness, fatigue, paresthesia, sedation, and hypersensitivity reactions to the CGRP inhibitors.
- Examples include lasmiditan (Reyvow), and eptinezumab-jjmr (Vyepti).
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Description
Test your knowledge on ergot derivatives and triptans, focusing on their mechanisms of action, effects, and examples. This quiz covers key concepts including CGRP inhibitors and their role in treating migraines. Explore the complexities of these medications and their pharmacological implications.
