Neurology Past Paper PDF

​§Leads to increased and prolonged Other effects stimulation of Ach Cholinergic crisis Migraines Ergot Derivatives Vascular, cluster, and Blo...

​§Leads to increased and prolonged Other effects stimulation of Ach Cholinergic crisis Migraines Ergot Derivatives Vascular, cluster, and Block alpha-adrenergic and serotonin CNS effects-dizziness, vertigo, ergotamine (Ergomar)​ migraine headache pain receptor sites in the brain to cause tingling sensation (warm) sumatriptan (Imitrex) relief constriction of cranial vessels, decrease CC effects-hypertension in cranial artery pulsation, decrease in GI effects-abdominal pain, N/V hyperperfusion of basilar artery bed Ergotism Triptans Bind to selective serotonin receptor CNS effects- drowsiness, Almotriptan, eletriptan sites to cause vasoconstriction of headache, paresthesia (Relpax) cranial vessels GI effects- dry mouth, nausea, abdominal pain, dysphagia CV effects- coronary artery vasospasm, MI, ventricular arrhythmias Almotriptan reported to have fewer side effects than other triptans Calcitonin CGRP inhibitors: Inhibit CGRP, a potent Lasmiditan: dizziness, fatigue, Eptinezumab-jjmr (Vyepti) Gene-Related Peptide vasodilator chemical released during paresthesia, sedation (CGRP) Inhibitors and migraine headache attacks Serotonin Agonist CGRP inhibitors: risk of Lasmiditan (Reyvow) Serotonin agonist: Has a selective hypersensitivity reactions action on a specific serotonin receptor Gepant substances: nausea Monoclonal antibodies: injection site reactions