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Epitopes and Antibody Recognition Quiz

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Questions and Answers

What is the difference between continuous and discontinuous epitopes?

Continuous epitopes are recognised by T cells, while discontinuous epitopes are recognised by B cells.

Continuous epitopes can be easily destroyed by protein denaturation, while discontinuous epitopes are more stable. (correct)

Continuous epitopes involve amino acids that are far apart in the polypeptide, while discontinuous epitopes involve amino acids that are next to each other in the polypeptide.

Continuous epitopes arise when the polypeptide folds into a 3D structure, while discontinuous epitopes are recognised by the antibody.

Where does V(D)J recombination occur and what is the result of this process?

V(D)J recombination occurs in the bone marrow and results in the production of red blood cells.

V(D)J recombination occurs in the primary lymphoid organs and results in the production of a diverse repertoire of antibodies/immunoglobulins. (correct)

V(D)J recombination occurs in the secondary lymphoid organs and results in the production of T cells.

V(D)J recombination occurs in the thymus and results in the production of white blood cells.

Where is IgA mainly found in the body?

On skin and mucosal surfaces

In tissue, blood, intestine, and placenta

On mucosal surfaces and fluids such as the lung, digestive tract, eyes, and urogenital tract (correct)

In the blood

______ recombination occurs in developing lymphocytes during B cell maturation

V(D)J Signup and view all the answers

IgG is found in tissue, blood, intestine, and ______

placenta Signup and view all the answers

Discontinuous epitopes are also known as ______ epitopes

conformational Signup and view all the answers

Question 1

What is the difference between continuous epitope and discontinuous epitope? Signup and view all the answers

Answer 1

Continuous epitope is a linear epitope that is recognised by the antibody and the amino acids involved are next to each other in the polypeptide. Discontinuous epitope, also known as conformational epitope, arises when the polypeptide folds into a 3D structure where amino acids in a distance come next to each other to form the epitope. Signup and view all the answers

Question 2

What is V(D)J recombination and where does it occur? Signup and view all the answers

Answer 2

V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early B cell maturation. It involves somatic recombination, which rearranges variable (V), joining (J), and in some cases, diversity (D) gene segments. V(D)J recombination occurs in the primary lymphoid organs (bone marrow for B cells and thymus for T cells) in a nearly random fashion. Signup and view all the answers

Question 3

What is the distribution of IgG, IgM, IgA, and IgE in the body? Signup and view all the answers

Answer 3

IgG is found in tissue, blood, intestine, and placenta. IgM is found in blood. IgA is mainly found on mucosal surfaces and fluids, such as lung, digestive tract, eyes, and urogenital tract. IgE is distributed on skin and mucosal surfaces. Signup and view all the answers