Comparison of B-cell and T-cell epitopes in allergen

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Questions and Answers

What is the purpose of the Allergome platform?

  • Integrating data related to allergens (correct)
  • Predicting allergenic proteins
  • Collecting sequence information for tumor antigens
  • Identifying B cell epitopes in allergic diseases

Which publication discusses relevant B cell epitopes in allergic disease?

  • Blood 1980; 55:607–11
  • Int Arch Allergy Immunol 2010; 152:1–11 (correct)
  • Virus Res 2009; 141:90–5
  • Immunol Today 1997; 18:267–8

What does SDAP provide according to the text?

  • Model for collecting sequence information of tumor antigens
  • Tools for allergenicity prediction (correct)
  • Database of evolutionary relationships of genes and proteins in the human immune system
  • Information on conserved B-cell epitopes

In which publication is there a discussion on tumor antigens and proteomics?

<p>Mol Cell Proteomics 2003; 2:388–98 (B)</p> Signup and view all the answers

What is the focus of ImmTree database?

<p>Evolutionary relationships of genes and proteins in the human immune system (B)</p> Signup and view all the answers

Which publication introduces a database for allergenic proteins and tools for allergenicity prediction?

<p>Bioinformation 2009; 3:344–5 (A)</p> Signup and view all the answers

What is the basis of the allergen prediction method proposed by Kong et al.?

<p>Identification of allergen motifs in a given protein sequence (B)</p> Signup and view all the answers

What did Zorzet et al. introduce in their computational approach for classifying amino acid sequences?

<p>Use of SVM and a similarity-based approach (C)</p> Signup and view all the answers

What is the purpose of ALGPRED created by Saha and Raghava?

<p>Analysis using SVM and a similarity-based approach (A)</p> Signup and view all the answers

How did Stadler and Stadler identify relevant motifs present in allergen sequences?

<p>Using the MEME motif discovery tool (A)</p> Signup and view all the answers

What criterion is used to consider a sequence as an allergenic sequence in the method by Stadler and Stadler?

<p>Scoring better than an E-value of 10^8 in pairwise alignment (A)</p> Signup and view all the answers

In the allergen prediction method by Kong et al., what was the motif length and motif number used to develop the database?

<p>Motif length of 35 amino acids and motif number of 500 (C)</p> Signup and view all the answers

What is the main difference between T-cell epitopes and B-cell epitopes?

<p>T-cell epitopes are linear, while B-cell epitopes can be either linear or conformational. (A)</p> Signup and view all the answers

Which database provides information related to 2434 allergens across categories like rice microbes, animals, and plants?

<p>ALLERGEN PRO database (B)</p> Signup and view all the answers

What type of data does ALLERGOME 4.0 provide an exhaustive repository of?

<p>IgE-binding compound data (D)</p> Signup and view all the answers

Which tool in ALLERGOME 4.0 allows users to upload raw data from both in vivo and in vitro experiments?

<p>ReTiME (B)</p> Signup and view all the answers

What makes predicting allergenicity based on known conformational epitopes a difficult task for B-cell epitopes?

<p>Difficulty in identifying conformational epitopes (C)</p> Signup and view all the answers

In which database can one find the ALLERGEN NOMENCLATURE and ALLERGEN PRO databases?

<p>IUIS database (D)</p> Signup and view all the answers

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