Epithelial and Connective Tissue Quiz
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Questions and Answers

What occurs when malignant cells cross the basal lamina?

  • The tumor classification is upgraded to a more dangerous level. (correct)
  • The tumor classification is downgraded to a less dangerous level.
  • The tumor becomes benign and poses no threat.
  • The tumor classification remains unchanged.
  • Which type of epithelium is primarily involved in the secretion of hormones directly into the bloodstream?

  • Exocrine epithelium
  • Glandular epithelium (correct)
  • Ciliated epithelium
  • Basal epithelium
  • What defines Victorian Transport across epithelial tissues?

  • It consists of transport occurring exclusively at the basal membrane.
  • It involves transport that occurs only via passive diffusion.
  • It is a random process without specific directional flow.
  • It requires active transport on one side of the cellular sheet and different transport on the other side. (correct)
  • Which transporters are mainly involved in the efflux transport in epithelial cells?

    <p>ATP-binding cassette (ABC) transporters (D)</p> Signup and view all the answers

    Which of the following locations does Victorian Transport NOT occur?

    <p>Epithelial lining of the lungs (D)</p> Signup and view all the answers

    What role do solute carrier (SLC) transporters primarily play?

    <p>They serve as influx transporters through secondary active or facilitated transport. (D)</p> Signup and view all the answers

    What is a primary characteristic of the epithelial cells involved in Victorian Transport?

    <p>They exhibit non-uniform distribution of transporters on opposing faces. (A)</p> Signup and view all the answers

    What is the primary component of mucous connective tissue?

    <p>Hyaluronic acid (C)</p> Signup and view all the answers

    Which connective tissue type is known to mainly consist of mesenchymal cells?

    <p>Mesenchymal connective tissue (A)</p> Signup and view all the answers

    Where is loose areolar connective tissue primarily found?

    <p>Under the epithelium (D)</p> Signup and view all the answers

    What is a significant feature of mesenchymal connective tissue observed in adults?

    <p>It is found in the pulp of teeth. (B)</p> Signup and view all the answers

    Which type of connective tissue is characterized by a loose arrangement of fibers and high tissue fluid content?

    <p>Loose areolar connective tissue (A)</p> Signup and view all the answers

    What contributes to the toxicity risk when drugs are administered with P-Glycoprotein inhibitors?

    <p>Enhanced drug absorption (D)</p> Signup and view all the answers

    Why do smaller molecules tend to be absorbed more readily in the body?

    <p>Their size allows faster diffusion across membranes (A)</p> Signup and view all the answers

    Under what conditions are weak acids more readily absorbed in the gastrointestinal tract?

    <p>In low pH environments (B)</p> Signup and view all the answers

    What mechanism does Ezetimibe utilize to lower cholesterol absorption?

    <p>Blocking the selective-cholesterol transporter (D)</p> Signup and view all the answers

    Which factor significantly impacts the degree of drug ionization in the body?

    <p>pKa of the drug (B)</p> Signup and view all the answers

    How do weak bases behave in relation to pH levels in the body?

    <p>More readily absorbed in higher pH environments (B)</p> Signup and view all the answers

    Which condition enhances the absorption of acetaminophen?

    <p>Presence of caffeine (B)</p> Signup and view all the answers

    What effect do Gliflozins have on blood glucose levels?

    <p>Block glucose reabsorption in kidneys (B)</p> Signup and view all the answers

    Which of the following characteristics is typical of lipid-soluble drugs compared to water-soluble drugs?

    <p>They readily diffuse across cell membranes (C)</p> Signup and view all the answers

    What is the primary role of macrophages in the immune system?

    <p>To phagocytose and destroy foreign substances (B)</p> Signup and view all the answers

    How do T lymphocytes differ from B lymphocytes in terms of maturation?

    <p>B cells mature in the bone marrow, T cells in the thymus (C)</p> Signup and view all the answers

    What percentage of circulating lymphocytes are B cells?

    <p>15% (A)</p> Signup and view all the answers

    What is the main function of memory cells in the immune system?

    <p>To remain dormant and retain immunological memory (B)</p> Signup and view all the answers

    What distinguishes null cells from other lymphocyte subtypes?

    <p>They have no known specific function (D)</p> Signup and view all the answers

    What is a defining characteristic of effector cells in the immune response?

    <p>They are differentiated and actively respond to antigens (C)</p> Signup and view all the answers

    Which statement correctly identifies a role of cytokines in the immune response?

    <p>They regulate and facilitate the inflammatory response (A)</p> Signup and view all the answers

    Where do lymphocytes primarily become immunologically competent?

    <p>In the thymus and bone marrow (D)</p> Signup and view all the answers

    After maturation, what differentiates the cells of a specific lymphocyte clone?

    <p>They can all recognize and respond to the same specific antigen (D)</p> Signup and view all the answers

    What is a significant aspect of the life span of T and B cells?

    <p>Some T cells can live for years while some B cells live for months (C)</p> Signup and view all the answers

    Which type of cell is primarily responsible for the first line of defense against bacterial infection?

    <p>Neutrophils (B)</p> Signup and view all the answers

    What characteristic feature distinguishes eosinophils from other white blood cells?

    <p>Bilobed nucleus (B)</p> Signup and view all the answers

    Which substance is released by basophils during an allergic reaction?

    <p>Histamine (C)</p> Signup and view all the answers

    The presence of which structure in females' neutrophils is characteristic for sex identification?

    <p>Barr body (B)</p> Signup and view all the answers

    What happens to neutrophils after they perform their function?

    <p>They die and form pus cells (B)</p> Signup and view all the answers

    Which blood cell type is known to become macrophages after migrating into connective tissue?

    <p>Monocytes (C)</p> Signup and view all the answers

    What physiological effect can occur due to the release of histamine by basophils during an allergic reaction?

    <p>Vasodilation and increased vessel permeability (B)</p> Signup and view all the answers

    What role do corticosteroids play in the regulation of eosinophil levels?

    <p>Depress eosinophil numbers in circulation (A)</p> Signup and view all the answers

    What is a defining feature of basophils compared to other leukocytes?

    <p>S-shaped nucleus (C)</p> Signup and view all the answers

    What is the primary function of eosinophils in the immune response?

    <p>Phagocytosis of antigen-antibody complexes and killing parasites (D)</p> Signup and view all the answers

    Flashcards

    Victorian Transport

    A process of transporting a substance across a whole layer of epithelial cells, involving active transport on one side and diffusion or facilitated diffusion on the other.

    Glandular Epithelium

    A type of epithelium found in glands, which are categorized into exocrine (secreting via ducts) and endocrine (secreting directly into circulation).

    Transport Across the Cell Membrane

    Molecules cross the phospholipid bilayer of a cell membrane using various transport mechanisms.

    Basal Lamina

    A structural component of the basement membrane, separating the epithelium from underlying connective tissue. If cancerous cells cross this, it indicates a more serious stage.

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    ATP-binding Cassette (ABC) Superfamily

    A family of transmembrane proteins that transport molecules across cell membranes, often using energy from ATP.

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    Solute Carrier (SLC) Superfamily

    A family of transmembrane proteins that transport molecules across cell membranes, often using the energy gradient of another molecule.

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    Transcellular Transport

    The movement of substances across a cell membrane from one side to the other, often involving both active and passive transport mechanisms.

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    Drug Absorption

    The process by which a substance moves from the site of administration into the bloodstream.

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    Drug Ionization & Absorption

    The tendency for a drug to be absorbed more readily when it is in a non-ionized form (uncharged and lipid-soluble).

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    pKa of a Drug

    The pH at which a drug is 50% ionized and 50% non-ionized.

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    Absorption of Weak Acids

    Weak acids are more readily absorbed in fluids with a lower pH (e.g., stomach) and tend to accumulate in fluids with a higher pH (e.g., urine).

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    Absorption of Weak Bases

    Weak bases are more readily absorbed in fluids with a higher pH (e.g., small intestine) and tend to accumulate in fluids with a lower pH (e.g., urine).

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    Ezetimibe

    A drug that blocks the absorption of cholesterol in the intestine, helping to lower blood cholesterol levels.

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    Gliflozins (Sodium-Glucose Co-transporter-2 Inhibitors)

    These drugs block the reabsorption of glucose in the kidneys, helping to lower blood glucose levels.

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    Victorian Transport by Drugs

    The use of drugs to modify the transport of substances across cell membranes.

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    Concomitant Inhibitors of P-Gp

    Substances that can inhibit the back efflux of a drug, increasing its absorption and potentially leading to toxicity.

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    Neutrophil

    A type of white blood cell with a multilobed nucleus connected by chromatin. It has pale cytoplasm and a characteristic "drumstick" appendage in females, containing the inactive X chromosome (Barr body).

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    Eosinophil

    A white blood cell characterized by a bilobed nucleus and eosinophilic granules in the cytoplasm.

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    Basophil

    A white blood cell with an S-shaped nucleus and abundant basophilic granules in the cytoplasm. They play a crucial role in allergic and inflammatory reactions.

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    Monocyte

    The largest white blood cell in a blood smear, recognized by a large, eccentric, kidney-shaped nucleus. They have irregular surface projections and abundant lysosomes.

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    Phagocytosis (Neutrophils)

    The process by which neutrophils engulf and destroy bacteria.

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    Phagocytosis (Eosinophils)

    The process by which eosinophils engulf and destroy antigen-antibody complexes and parasitic invaders.

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    Basophil Granule Degranulation

    The release of histamine and heparin from basophil granules, triggering allergic and inflammatory responses.

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    Anaphylactic Shock

    A life-threatening condition caused by widespread vasodilation, reduced blood volume, and respiratory insufficiency due to basophil degranulation.

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    Monocyte Differentiation

    The process by which monocytes migrate into connective tissue and transform into macrophages.

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    Mononuclear Phagocytic System

    A group of cells, including macrophages, that are involved in phagocytosis and immune response.

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    What are macrophages?

    Specialized cells that engulf and destroy unwanted particles, such as bacteria, dead cells, and foreign substances, within small compartments called phagosomes.

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    What do macrophages produce?

    Macrophages release proteins called cytokines, which play a crucial role in starting and controlling inflammation and immune responses.

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    How do macrophages present antigens?

    Macrophages break down foreign invaders into smaller parts called epitopes, presenting them to T lymphocytes (T cells) to trigger an immune response.

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    What are lymphocytes?

    These are white blood cells responsible for immunity. They are found in both blood and lymph tissue.

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    What do B lymphocytes do?

    B lymphocytes (B cells) are responsible for producing antibodies, which are proteins that tag and destroy pathogens.

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    What do T lymphocytes do?

    T lymphocytes (T cells) directly attack and destroy infected cells or cancerous cells.

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    What are null cells?

    Null cells (NK cells) are a type of lymphocyte that kill infected or abnormal cells without needing to be specifically programmed like T cells.

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    What are memory cells?

    These are B or T lymphocytes that have encountered an antigen and survived, creating a memory of it. They are primed to respond quickly to a subsequent encounter with the same antigen.

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    What are effector cells?

    These are B or T lymphocytes that directly participate in the current immune response.

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    What is immunological competence?

    The process where lymphocytes mature and develop specific surface receptors for recognizing antigens.

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    Mesenchymal Connective Tissue

    A type of connective tissue found in the embryo, containing mesenchymal cells embedded in a gel-like ground substance with scattered reticular fibers. It's essential for embryonic development and is present in the pulp of teeth in adults.

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    Mucous Connective Tissue

    A loose, gel-like connective tissue rich in hyaluronic acid, with sparse collagen fibers and fibroblasts. It's found in the umbilical cord, providing cushioning and support.

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    Loose Areolar Connective Tissue

    A type of connective tissue with loosely arranged fibers and dispersed cells within a gel-like ground substance. It's found under epithelial layers, around blood vessels, and provides support and flexibility.

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    Dense Regular Connective Tissue

    A type of connective tissue with densely packed collagen fibers arranged in a parallel fashion, providing strong tensile strength in a single direction. Found in tendons and ligaments.

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    Dense Irregular Connective Tissue

    A type of connective tissue with densely packed collagen fibers arranged in an irregular manner, providing strength and support in multiple directions. Found in the dermis of skin.

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    Study Notes

    Innate Immunity

    • Innate immunity is an immediate, non-specific response to pathogens.
    • It doesn't confer long-lasting immunity.
    • The response occurs in three phases: early induced responses, adaptive immune response, and removal of the infectious agent.
    • Cells of innate immunity include neutrophils, monocytes, macrophages, natural killer (NK) cells, eosinophils, and basophils.

    Adaptive Immunity

    • Adaptive immunity is specific, has immunologic memory, and responds rapidly to a second antigen exposure.
    • It involves two main types: active and passive immunity.
    • Active immunity: the body's own response to foreign material.
      • Active natural immunity: immunity developed through exposure to foreign Ags.
      • Active artificial immunity: immunity conferred through the introduction of vaccines.
    • Passive immunity: the body receives preformed antibodies.
      • Passive natural immunity: antibodies transferred from mother to the fetus.
      • Passive artificial immunity: the administration of preformed antibodies.
    • Cells involved include macrophages and lymphocytes (B and T cells).
    • B-cells: involved in antibody-mediated immunity.
    • T-cells: involved in cell-mediated immunity.

    Components of Adaptive Immunity

    • Macrophages: antigen presenting cells.
    • B-cells: mature in the bone marrow, express IgM immunoglobulin receptors (BCRs)
      • T-cell-dependent activation: involves T-cells for full B-cell response; activation results in antibody production.
      • T-cell-independent activation: does not require T-cell support.
    • T-cells:
      • CD4-positive T-cells: regulate B-cell activation and function.
      • CD8-positive T-cells: destroy infected or cancerous cells (cytotoxic T lymphocytes).
      • T-regulatory cells (T(regs)): suppress the immune response.

    Immune Cells

    • Neutrophils: the first responders to infection; phagocytosis.
    • Monocytes/Macrophages: phagocytosis, cytokine production, and antigen presentation.
    • Natural Killer (NK) cells: identify and kill infected or cancerous cells.
    • Eosinophils and Basophils: involved in allergic reactions and defense against parasites.
    • Lymphocytes (B and T cells): responsible for the adaptive immune response.

    Cytokines

    • Cytokines are proteins involved in communication between cells during the immune response.
    • Types include interleukins (ILs), colony-stimulating factors (CSFs), tumor necrosis factors (TNFs), transforming growth factors (TGFs), and interferons (IFNs).

    Complement System

    • The complement system is a collection of proteins in blood serum that work together to enhance the immune response.
    • Activation occurs through three pathways: classical, alternative, and lectin pathways.
    • The result of the pathways is to form a membrane attack complex (MAC) leading to cell lysis.

    Major Histocompatibility Complex (MHC)

    • The MHC is a set of polymorphic genes on chromosome 6.
    • MHC Class I molecules are expressed on nearly all nucleated cells.
    • MHC Class II molecules are expressed mainly on antigen-presenting cells (APCs).
    • They are involved in the presentation of antigens to T cells, enabling pathogen recognition and killing.

    Immunodeficiency Diseases

    • Primary immunodeficiencies: genetic defects in immune cells/proteins.
    • Secondary immunodeficiencies: acquired impairments due to other factors like infections, malignancy, or drugs.
    • Defects can affect phagocytes, B cells, T cells, or complement proteins.

    Types Of Hypersensitivity Reactions

    • Type I: immediate hypersensitivity (allergy); mediated by IgE, mast cells, and basophils leading to the release of inflammatory mediators.
      • Example: anaphylaxis, allergies, asthma.
    • Type II: cytotoxic hypersensitivity; antibody-mediated destruction or dysfunction of cells.
      • Example: blood transfusion reactions, hemolytic disease of the newborn.
    • Type III: immune complex-mediated hypersensitivity; immune complexes deposit in tissues, triggering inflammation.
      • Example: lupus, rheumatoid arthritis.
    • Type IV: delayed hypersensitivity; cell-mediated response, T cells, and cytokines leading to tissue damage.
      • Example: contact dermatitis, transplant rejection.

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    Description

    This quiz covers key concepts related to epithelial and connective tissues, including transport mechanisms and characteristics of different types of tissues. Test your knowledge on topics such as Victorian Transport, solute carrier transporters, and the properties of connective tissues. Perfect for students studying biology or healthcare.

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