9 Questions
What is the most common lethal genetic disease affecting Caucasians?
Cystic fibrosis
In which population is cystic fibrosis uncommon?
Asians
Which glands are affected by the widespread disorder in epithelial chloride transport?
Exocrine glands
What is the function of the CFTR protein when located in the plasma membrane?
Regulation of other ion channels
What happens if a mutation disturbs protein folding, such as the F508 mutation?
Intracellular degradation of CFTR
What are the carriers of cystic fibrosis called?
Asymptomatic individuals
Which of the following is NOT affected by the abnormal viscid mucus secretions in cystic fibrosis?
Nervous system
Where is CFTR synthesized?
Rough endoplasmic reticulum
What is the prevalence of carriers of cystic fibrosis in the population?
~2-4%
Test your knowledge about cystic fibrosis, the most common lethal genetic disease affecting Caucasians, with widespread effects on epithelial chloride transport and fluid secretion in various bodily systems.
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