24 Questions
What is the mechanism of action of valproic acid?
Blockage of T-type calcium channels and GABA transaminase
What is the effect of phenytoin and carbamazepine on the metabolism of another anticonvulsant?
They induce the metabolism of valproic acid
What is the primary concern during pregnancy for women taking valproic acid?
Risk of teratogenicity
What is the most common adverse effect of vigabatrin?
Vision loss
What is the mechanism of action of zonisamide?
Blockage of voltage-sensitive sodium channels
What is the effect of valproic acid on the metabolism of other anticonvulsants?
It inhibits the metabolism of phenobarbital
What is the primary indication for vigabatrin?
Adjunctive therapy for partial seizures
What is the protein binding of valproic acid?
~90%
Which of the following antiepileptic medications is known to cause oligohidrosis?
Topiramate
What is the primary mechanism of action of Cannabidiol (Epidiolex)?
Binding to cannabinoid receptors in the brain
Which of the following antiepileptic medications can decrease the efficacy of hormonal contraceptives?
Phenytoin, phenobarbital, carbamazepine, and oxacarbazepine
What should be initiated in women taking antiepileptic drugs?
High-dose folic acid
Why should women who are pregnant and taking antiepileptic medications register with the North American AED Registry?
To monitor for potential birth defects
Which of the following is a first-line medication for partial seizures?
Carbamazepine
What is a common adverse effect of Cannabidiol (Epidiolex)?
Somnolence
Why should divalproex be avoided in women of childbearing age?
It can cause birth defects
What is the primary mechanism of action of tiagabine?
Inhibiting GABA reuptake transporters
Which of the following adverse effects is commonly associated with pregabalin?
Weight gain and edema
What is the primary indication for phenobarbital?
Primary treatment for status epilepticus
Which of the following drugs is converted to phenobarbital?
Primidone
What is a unique property of tiagabine's pharmacokinetics?
Not highly protein-bound
Which of the following drugs can cause seizures in individuals without epilepsy?
Tiagabine
What is the mechanism of action of phenobarbital?
Enhancing GABA action as an inhibitory NT
Which of the following drugs is primarily eliminated by the kidneys?
Pregabalin
This quiz covers various medications used to treat epilepsy, including their mechanisms of action, indications, and adverse effects. Topics include Phenobarbital, Primidone, Pregabalin, Tiagabine, Topiramate, Valproic acid, Vigabatrin, Zonisamide, and CBD. It also touches on women's health and epilepsy.
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