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Questions and Answers
What happens when the glucocorticoid receptor (GR) binds to glucocorticoid response elements (GRE) in the promoter regions of genes?
What happens when the glucocorticoid receptor (GR) binds to glucocorticoid response elements (GRE) in the promoter regions of genes?
- Activation of inactive multi-protein complexes
- Inhibition of gene expression
- Enhancement of GR binding to DNA
- Transcriptional induction or repression of target genes (correct)
Where is the glucocorticoid receptor (GR) held in the absence of glucocorticoids like cortisol?
Where is the glucocorticoid receptor (GR) held in the absence of glucocorticoids like cortisol?
- Mitochondria
- Endoplasmic reticulum
- Nucleus
- Cytosol (correct)
What happens to the glucocorticoid receptor (GR) when cortisol binds to it?
What happens to the glucocorticoid receptor (GR) when cortisol binds to it?
- It forms a trimer
- It becomes inactive
- It dissociates from the regulatory complex (correct)
- It remains bound to the cytoplasm
What is required by the Glucocorticoid Receptor Dimer to stimulate the basal transcription machinery?
What is required by the Glucocorticoid Receptor Dimer to stimulate the basal transcription machinery?
What type of DNA sequences are glucocorticoid response elements (GRE)?
What type of DNA sequences are glucocorticoid response elements (GRE)?
What is one of the roles of the zinc finger DNA binding domain in the Glucocorticoid Receptor Dimer?
What is one of the roles of the zinc finger DNA binding domain in the Glucocorticoid Receptor Dimer?
Where does the transcription of target genes occur after glucocorticoid activation?
Where does the transcription of target genes occur after glucocorticoid activation?
What happens when Glucocorticoid Receptor Dimer interacts with repressors?
What happens when Glucocorticoid Receptor Dimer interacts with repressors?
What is the effect of glucocorticoid (cortisol) binding to Glucocorticoid Receptor?
What is the effect of glucocorticoid (cortisol) binding to Glucocorticoid Receptor?
What initiates the expression of target genes by Glucocorticoid Receptor Dimer?
What initiates the expression of target genes by Glucocorticoid Receptor Dimer?
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