10 Questions
What happens when the glucocorticoid receptor (GR) binds to glucocorticoid response elements (GRE) in the promoter regions of genes?
Transcriptional induction or repression of target genes
Where is the glucocorticoid receptor (GR) held in the absence of glucocorticoids like cortisol?
Cytosol
What happens to the glucocorticoid receptor (GR) when cortisol binds to it?
It dissociates from the regulatory complex
What is required by the Glucocorticoid Receptor Dimer to stimulate the basal transcription machinery?
Coactivator proteins
What type of DNA sequences are glucocorticoid response elements (GRE)?
Palindromic DNA
What is one of the roles of the zinc finger DNA binding domain in the Glucocorticoid Receptor Dimer?
Enhance Transcription
Where does the transcription of target genes occur after glucocorticoid activation?
Nucleus
What happens when Glucocorticoid Receptor Dimer interacts with repressors?
Inhibit the basal transcription machinery
What is the effect of glucocorticoid (cortisol) binding to Glucocorticoid Receptor?
Dissociation from regulatory complex
What initiates the expression of target genes by Glucocorticoid Receptor Dimer?
Binding to Glucocorticoid Response Elements (GRE)
Test your knowledge on epigenetics and DNA methylation processes including the role of enzymes like HDAC1/2, Dnmt3, and Dnmt1, as well as proteins like MeCP2. Understand how DNA methylation affects gene expression, inheritance, and transcriptional repression.
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