Epigenetics and DNA Methylation Quiz
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Questions and Answers

What happens when the glucocorticoid receptor (GR) binds to glucocorticoid response elements (GRE) in the promoter regions of genes?

  • Activation of inactive multi-protein complexes
  • Inhibition of gene expression
  • Enhancement of GR binding to DNA
  • Transcriptional induction or repression of target genes (correct)

    • Where is the glucocorticoid receptor (GR) held in the absence of glucocorticoids like cortisol?

  • Mitochondria
  • Endoplasmic reticulum
  • Nucleus
  • Cytosol (correct)

    • What happens to the glucocorticoid receptor (GR) when cortisol binds to it?

  • It forms a trimer
  • It becomes inactive
  • It dissociates from the regulatory complex (correct)
  • It remains bound to the cytoplasm

    • What is required by the Glucocorticoid Receptor Dimer to stimulate the basal transcription machinery?

    <p>Coactivator proteins (C)</p> Signup and view all the answers

    What type of DNA sequences are glucocorticoid response elements (GRE)?

    <p>Palindromic DNA (C)</p> Signup and view all the answers

    What is one of the roles of the zinc finger DNA binding domain in the Glucocorticoid Receptor Dimer?

    <p>Enhance Transcription (B)</p> Signup and view all the answers

    Where does the transcription of target genes occur after glucocorticoid activation?

    <p>Nucleus (A)</p> Signup and view all the answers

    What happens when Glucocorticoid Receptor Dimer interacts with repressors?

    <p>Inhibit the basal transcription machinery (C)</p> Signup and view all the answers

    What is the effect of glucocorticoid (cortisol) binding to Glucocorticoid Receptor?

    <p>Dissociation from regulatory complex (D)</p> Signup and view all the answers

    What initiates the expression of target genes by Glucocorticoid Receptor Dimer?

    <p>Binding to Glucocorticoid Response Elements (GRE) (B)</p> Signup and view all the answers

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