Epigenetics and DNA Methylation Quiz
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Questions and Answers

What happens when the glucocorticoid receptor (GR) binds to glucocorticoid response elements (GRE) in the promoter regions of genes?

  • Activation of inactive multi-protein complexes
  • Inhibition of gene expression
  • Enhancement of GR binding to DNA
  • Transcriptional induction or repression of target genes (correct)

Where is the glucocorticoid receptor (GR) held in the absence of glucocorticoids like cortisol?

  • Mitochondria
  • Endoplasmic reticulum
  • Nucleus
  • Cytosol (correct)

What happens to the glucocorticoid receptor (GR) when cortisol binds to it?

  • It forms a trimer
  • It becomes inactive
  • It dissociates from the regulatory complex (correct)
  • It remains bound to the cytoplasm

What is required by the Glucocorticoid Receptor Dimer to stimulate the basal transcription machinery?

<p>Coactivator proteins (C)</p> Signup and view all the answers

What type of DNA sequences are glucocorticoid response elements (GRE)?

<p>Palindromic DNA (C)</p> Signup and view all the answers

What is one of the roles of the zinc finger DNA binding domain in the Glucocorticoid Receptor Dimer?

<p>Enhance Transcription (B)</p> Signup and view all the answers

Where does the transcription of target genes occur after glucocorticoid activation?

<p>Nucleus (A)</p> Signup and view all the answers

What happens when Glucocorticoid Receptor Dimer interacts with repressors?

<p>Inhibit the basal transcription machinery (C)</p> Signup and view all the answers

What is the effect of glucocorticoid (cortisol) binding to Glucocorticoid Receptor?

<p>Dissociation from regulatory complex (D)</p> Signup and view all the answers

What initiates the expression of target genes by Glucocorticoid Receptor Dimer?

<p>Binding to Glucocorticoid Response Elements (GRE) (B)</p> Signup and view all the answers

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