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Questions and Answers
What is the distinguishing feature of uncompetitive inhibition?
What is the distinguishing feature of uncompetitive inhibition?
- Inhibitor binds to the active site of enzyme
- Adding more substrate relieves inhibition
- Inhibitor binds only to enzyme-substrate complex (correct)
- Inhibitor is similar in structure to substrate
How does competitive inhibition affect Vmax and KM?
How does competitive inhibition affect Vmax and KM?
- Vmax decreases, KM decreases
- Vmax remains the same, KM increases (correct)
- Vmax increases, KM remains the same
- Vmax decreases, KM remains the same
Which type of irreversible inhibitors involves the formation of a reactive intermediate that covalently modifies the enzyme?
Which type of irreversible inhibitors involves the formation of a reactive intermediate that covalently modifies the enzyme?
- Affinity Labels
- Group-Specific Reagents
- Transition-state Analogs
- Suicide Inhibitors (correct)
What is a key characteristic of transition-state analogs as irreversible inhibitors of enzymes?
What is a key characteristic of transition-state analogs as irreversible inhibitors of enzymes?
Which type of reversible inhibitor is more specific for an enzyme's active site compared to group-specific reagents?
Which type of reversible inhibitor is more specific for an enzyme's active site compared to group-specific reagents?
Which strategy involves a molecule other than water playing the role of a proton donor or proton acceptor?
Which strategy involves a molecule other than water playing the role of a proton donor or proton acceptor?
What type of catalysis involves the active site containing a reactive group that becomes temporarily modified covalently during the catalytic reaction?
What type of catalysis involves the active site containing a reactive group that becomes temporarily modified covalently during the catalytic reaction?
Which strategy involves stabilizing negative charge on a reaction intermediate using a metal ion?
Which strategy involves stabilizing negative charge on a reaction intermediate using a metal ion?
What factor enhances the rate of enzyme-catalyzed reactions by increasing the chances of interactions between enzyme and substrate?
What factor enhances the rate of enzyme-catalyzed reactions by increasing the chances of interactions between enzyme and substrate?
Which statement is true about enzyme inhibition?
Which statement is true about enzyme inhibition?
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