Enzyme Catalysis Strategies Quiz

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Questions and Answers

What type of catalysis involves a molecule other than water playing the role of proton donor or proton acceptor?

Covalent Catalysis
General Acid-Base Catalysis (correct)
Metal Ion Catalysis
Catalysis by Approximation and Orientation

In Metal Ion Catalysis, how does the metal ion contribute to catalysis?

Stabilizes negative charge on a reaction intermediate (correct)
Stabilizes positive charge on a reaction intermediate
Serves as a nucleophile
Decreases the acidity of nearby molecules

What happens to enzyme activity if the pH deviates significantly from the optimal pH?

Decreases (correct)
Remains constant
Increases
Stops completely

Which type of inhibition involves rapid dissociation of the enzyme-inhibitor complex?

Competitive Inhibition (B) Signup and view all the answers

In catalysis by Approximation and Orientation, why are two distinct substrates brought into close proximity and specific orientation?

To enhance reaction efficiency (A) Signup and view all the answers

What distinguishes competitive inhibition from uncompetitive inhibition?

Competitive inhibition prevents binding of the regular substrate, while uncompetitive inhibition binds only to the enzyme-substrate complex. (A) Signup and view all the answers

How do irreversible inhibitors differ from reversible inhibitors?

Irreversible inhibitors bind tightly either by covalent or noncovalent bonds and dissociate slowly from the enzyme, while reversible inhibitors can be overcome by increasing substrate concentration. (A) Signup and view all the answers

How do suicide inhibitors differ from transition-state analogs?

Suicide inhibitors are chemically modified substrates that bind to enzymes and form a reactive intermediate that inactivates the enzyme, while transition-state analogs are substrate analogs that covalently modify active-site residues. (A) Signup and view all the answers

Which statement accurately describes uncompetitive inhibition?

Uncompetitive inhibition occurs when the enzyme-substrate-inhibitor complex does not produce a product. (A) Signup and view all the answers

What distinguishes noncompetitive inhibition from competitive inhibition?

Noncompetitive inhibition binds inhibitor and substrate at different sites, while competitive inhibition has an inhibitor similar in structure to the substrate. (B) Signup and view all the answers

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