Enzyme Catalysis Strategies Quiz
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Questions and Answers

What type of catalysis involves a molecule other than water playing the role of proton donor or proton acceptor?

  • Covalent Catalysis
  • General Acid-Base Catalysis (correct)
  • Metal Ion Catalysis
  • Catalysis by Approximation and Orientation

    • In Metal Ion Catalysis, how does the metal ion contribute to catalysis?

  • Stabilizes negative charge on a reaction intermediate (correct)
  • Stabilizes positive charge on a reaction intermediate
  • Serves as a nucleophile
  • Decreases the acidity of nearby molecules

    • What happens to enzyme activity if the pH deviates significantly from the optimal pH?

  • Decreases (correct)
  • Remains constant
  • Increases
  • Stops completely

    • Which type of inhibition involves rapid dissociation of the enzyme-inhibitor complex?

    <p>Competitive Inhibition</p> Signup and view all the answers

    In catalysis by Approximation and Orientation, why are two distinct substrates brought into close proximity and specific orientation?

    <p>To enhance reaction efficiency</p> Signup and view all the answers

    What distinguishes competitive inhibition from uncompetitive inhibition?

    <p>Competitive inhibition prevents binding of the regular substrate, while uncompetitive inhibition binds only to the enzyme-substrate complex.</p> Signup and view all the answers

    How do irreversible inhibitors differ from reversible inhibitors?

    <p>Irreversible inhibitors bind tightly either by covalent or noncovalent bonds and dissociate slowly from the enzyme, while reversible inhibitors can be overcome by increasing substrate concentration.</p> Signup and view all the answers

    How do suicide inhibitors differ from transition-state analogs?

    <p>Suicide inhibitors are chemically modified substrates that bind to enzymes and form a reactive intermediate that inactivates the enzyme, while transition-state analogs are substrate analogs that covalently modify active-site residues.</p> Signup and view all the answers

    Which statement accurately describes uncompetitive inhibition?

    <p>Uncompetitive inhibition occurs when the enzyme-substrate-inhibitor complex does not produce a product.</p> Signup and view all the answers

    What distinguishes noncompetitive inhibition from competitive inhibition?

    <p>Noncompetitive inhibition binds inhibitor and substrate at different sites, while competitive inhibition has an inhibitor similar in structure to the substrate.</p> Signup and view all the answers

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