10 Questions
What type of catalysis involves a molecule other than water playing the role of proton donor or proton acceptor?
General Acid-Base Catalysis
In Metal Ion Catalysis, how does the metal ion contribute to catalysis?
Stabilizes negative charge on a reaction intermediate
What happens to enzyme activity if the pH deviates significantly from the optimal pH?
Decreases
Which type of inhibition involves rapid dissociation of the enzyme-inhibitor complex?
Competitive Inhibition
In catalysis by Approximation and Orientation, why are two distinct substrates brought into close proximity and specific orientation?
To enhance reaction efficiency
What distinguishes competitive inhibition from uncompetitive inhibition?
Competitive inhibition prevents binding of the regular substrate, while uncompetitive inhibition binds only to the enzyme-substrate complex.
How do irreversible inhibitors differ from reversible inhibitors?
Irreversible inhibitors bind tightly either by covalent or noncovalent bonds and dissociate slowly from the enzyme, while reversible inhibitors can be overcome by increasing substrate concentration.
How do suicide inhibitors differ from transition-state analogs?
Suicide inhibitors are chemically modified substrates that bind to enzymes and form a reactive intermediate that inactivates the enzyme, while transition-state analogs are substrate analogs that covalently modify active-site residues.
Which statement accurately describes uncompetitive inhibition?
Uncompetitive inhibition occurs when the enzyme-substrate-inhibitor complex does not produce a product.
What distinguishes noncompetitive inhibition from competitive inhibition?
Noncompetitive inhibition binds inhibitor and substrate at different sites, while competitive inhibition has an inhibitor similar in structure to the substrate.
Test your knowledge on the different strategies used by enzymes to catalyze specific reactions such as Covalent Catalysis, General Acid-Base Catalysis, Metal Ion Catalysis, and Catalysis by Approximation and Orientation. Learn about how enzymes utilize various mechanisms to enhance reaction rates.
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