28 Questions
What is the term used to describe the free energy released on the binding of a substrate to an enzyme?
Binding energy
Which process involves the modification of the shape of the active site through the binding of a substrate?
Induced fit
In enzyme-substrate binding, when does the maximal binding energy get released?
When the transition state is formed
Which factor determines whether the transition state will become a substrate or a product?
Energy difference (ΔG)
How is specificity of binding in enzymes affected?
By the arrangement of atoms in the active site
Which type of interaction is crucial for lowering the activation energy in enzyme-catalyzed reactions?
Weak non-specific interactions
What happens to the transition state during an enzyme-catalyzed reaction?
It becomes either a substrate or a product
Why is conformation selection important in enzyme-substrate interactions?
To guarantee only certain substrates bind efficiently
What is the main factor that determines the specificity of binding in enzyme-substrate interactions?
Arrangement of atoms in the active site
Which concept describes the phenomenon where the shape of the active site can be altered upon binding of the substrate?
Induced fit
What is the role of binding energy between enzyme and substrate in catalysis?
Lowering activation energy
Which statement accurately describes what happens to the transition state during an enzyme-catalyzed reaction?
Transition state is not stable and will become either substrate or product
How does maximal binding energy get released during enzyme-catalyzed reactions?
When weak interactions are fully formed
In enzyme-substrate interactions, what contributes significantly to lowering the activation energy?
Induced fit mechanism
Which type of interaction plays a crucial role in forming weak interactions between substrate and enzyme?
Van der Waals forces
What determines whether the transition state will lead to the formation of a substrate or a product?
The relative stability of the transition state compared to substrates and products
What is meant by 'conformation selection' in enzyme-substrate interactions?
The specific binding of substrates only to enzymes with appropriate conformational active sites
What type of energy facilitates the formation of weak interactions between enzymes and substrates?
Binding energy
What is the main factor that determines the specificity of binding between an enzyme and a substrate?
Shape of the active site
Which phenomenon involves the formation of a large number of weak interactions between a substrate and an enzyme?
Transition state formation
How does binding energy contribute to lowering the activation energy in enzyme-catalyzed reactions?
By stabilizing the transition state
During an enzyme-substrate interaction, what determines whether the transition state will proceed to form a substrate or a product?
Energy difference (ΔG)
Which statement best describes the role of induced fit in enzyme catalysis?
It alters the active site conformation.
What occurs when the transition state forms during an enzyme-catalyzed reaction?
Maximal binding energy is released.
In enzyme-substrate interactions, what plays a crucial role in forming a full complement of weak interactions?
Shape of the active site
Which factor influences whether the transition state will become a substrate or a product during an enzyme-catalyzed reaction?
Energy difference (ΔG)
What is the significance of free energy release in enzyme-substrate interactions?
It contributes to lowering activation energy.
Which concept is essential for ensuring that a substrate binds only to enzymes with a specific active site conformation?
Conformation selection
Test your knowledge on enzymes, their role in accelerating reactions, and their specificity in binding substrates to produce specific products. Learn about proteolytic enzymes and their ability to catalyze proteolysis. Explore examples like papain and their functions.
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