enzyme mech and inhibition

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28 Questions

What is the main way enzymes reduce the activation energy?

By stabilising the transition state

Which model states that the enzyme's active site is exactly the correct shape for the substrate to bind to?

Lock and key model

What is the point of highest energy on the progress of a reaction curve called?

Transition state

Which type of reaction do most enzymes catalyze?

One type of reaction

What does the induced fit model propose?

Substrate induces a change in confirmation

What ratio is used to obtain rate enhancement?

Kcat/Kun

What occurs at the point of highest energy on the progress of a reaction curve?

Bond breakage and formation

What do enzymes primarily catalyse?

Reactions with high activation energy

What does substrate specificity refer to?

An enzyme's ability to bind only one optical isomer

What type of model suggests that small molecules with a similar shape to part of the substrate cannot bind?

Lock and key model

Which type of inhibitor forms covalent interactions with the enzyme and does not come off once it binds?

Irreversible inhibitor

In which process does a molecule become irreversibly bound and inactivate the enzyme?

Suicide inhibition

What is the measure of affinity between enzyme and inhibitor in competitive inhibition?

Ki

Which type of inhibitor binds at the same site as the substrate and blocks access for the substrate?

Competitive inhibitor

Which type of inhibitor induces a conformational change in the enzyme and prevents catalysis?

Non-competitive inhibitor

Which plot can be used to distinguish between competitive and non-competitive inhibitors?

Lineweaver-Burk plot

Which molecule is an example of a suicide inhibitor?

5-fluorouracil

Which enzyme is methotrexate a competitive inhibitor for?

Dihydrofolate reductase

Enzymes are generally smaller than their substrates.

False

The lock and key model suggests that small molecules with a similar shape to part of the substrate cannot bind.

True

Enzymes can catalyze multiple types of reactions.

True

The induced fit model proposes that the substrate induces a change in confirmation so it can fit into the active site of the enzyme.

True

The main way enzymes reduce the activation energy is by increasing the energy of the transition state.

False

Non-competitive inhibitors do not affect the Vmax of an enzyme

False

Sarin is an example of a reversible inhibitor of acetylcholinesterase

False

Reversible inhibitors can be removed from the enzyme by dialysis due to covalent interactions

False

Methotrexate is a non-competitive inhibitor for the enzyme dihydrofolate reductase

False

The Lineweaver-Burk plot can be used to distinguish between competitive and non-competitive inhibitors

True

Test your knowledge of enzyme-substrate complexes and enzyme models with this quiz. Learn about the lock and key model, active sites, and the specificity of enzyme catalysis.

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