Enzyme Catalysis by Approximation Quiz
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Questions and Answers

What term describes a chemical species with an affinity for a positive charge and acts as an electron donor?

  • Coenzyme
  • Nucleophile (correct)
  • Prosthetic group
  • Electrophile
  • Which type of effector involves the substrate binding to the allosteric site in an enzyme?

  • Heterotropic effector
  • Homotropic effector (correct)
  • Cofactor
  • NAD+
  • What is the term for a small organic molecule required for enzyme activity?

  • Nucleophile
  • Coenzyme (correct)
  • Prosthetic group
  • Cofactor
  • In covalent catalysis, what does the enzyme form temporarily with the substrate to catalyze the reaction?

    <p>Cosubstrate</p> Signup and view all the answers

    What term describes the released energy when weak interactions are formed between the enzyme and substrate, promoting specificity?

    <p>Binding energy</p> Signup and view all the answers

    Which type of effector involves a ligand binding to the allosteric site that is different from the substrate?

    <p>Heterotropic effector</p> Signup and view all the answers

    How is metal ion catalysis involved in nucleophile formation?

    <p>Raising binding energy</p> Signup and view all the answers

    In NMP kinase, what is the purpose of having a divalent ion-bound nucleotide as the true substrate?

    <p>Providing a specific conformation for binding</p> Signup and view all the answers

    How does proximity aid in catalysis in NMP kinase?

    <p>Bringing NTP and NMP close together</p> Signup and view all the answers

    What is the role of the P-loop in NMP kinase activation?

    <p>Triggering a lid domain closure</p> Signup and view all the answers

    What effect does metal ion catalysis have on serine proteases like chymotrypsin?

    <p>Enhancing acid-base catalysis</p> Signup and view all the answers

    How does metal ion catalysis contribute to enzyme function in restriction endonucleases?

    <p>Promotes bond cleavage by acting as a covalent catalyst</p> Signup and view all the answers

    What role does carbonic anhydrase play in the reaction of CO2 to HCO3-?

    <p>Acts as a proton acceptor</p> Signup and view all the answers

    How does Zn2+ contribute to the reaction catalyzed by carbonic anhydrase?

    <p>Lowers H2O's pKa</p> Signup and view all the answers

    What is the mechanism by which His 64 facilitates the reaction in carbonic anhydrase?

    <p>Moves a proton from protein surface to H2O</p> Signup and view all the answers

    In carbonic anhydrase, what is the function of OH-?

    <p>Attacks HCO3-</p> Signup and view all the answers

    What is the main impact of carbonic anhydrase on the speed of the reaction?

    <p>Facilitates rapid conversion</p> Signup and view all the answers

    How does carbonic anhydrase promote the regeneration of its active site?

    <p>Binds to Zn2+ again</p> Signup and view all the answers

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