Enzyme Catalysis by Approximation Quiz

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What term describes a chemical species with an affinity for a positive charge and acts as an electron donor?

Coenzyme

Nucleophile (correct)

Prosthetic group

Electrophile

Which type of effector involves the substrate binding to the allosteric site in an enzyme?

Heterotropic effector

Homotropic effector (correct)

Cofactor

NAD+

What is the term for a small organic molecule required for enzyme activity?

Nucleophile

Coenzyme (correct)

Prosthetic group

Cofactor

In covalent catalysis, what does the enzyme form temporarily with the substrate to catalyze the reaction?

Cosubstrate Signup and view all the answers

What term describes the released energy when weak interactions are formed between the enzyme and substrate, promoting specificity?

Binding energy Signup and view all the answers

Which type of effector involves a ligand binding to the allosteric site that is different from the substrate?

Heterotropic effector Signup and view all the answers

How is metal ion catalysis involved in nucleophile formation?

Raising binding energy Signup and view all the answers

In NMP kinase, what is the purpose of having a divalent ion-bound nucleotide as the true substrate?

Providing a specific conformation for binding Signup and view all the answers

How does proximity aid in catalysis in NMP kinase?

Bringing NTP and NMP close together Signup and view all the answers

What is the role of the P-loop in NMP kinase activation?

Triggering a lid domain closure Signup and view all the answers

What effect does metal ion catalysis have on serine proteases like chymotrypsin?

Enhancing acid-base catalysis Signup and view all the answers

How does metal ion catalysis contribute to enzyme function in restriction endonucleases?

Promotes bond cleavage by acting as a covalent catalyst Signup and view all the answers

What role does carbonic anhydrase play in the reaction of CO2 to HCO3-?

Acts as a proton acceptor Signup and view all the answers

How does Zn2+ contribute to the reaction catalyzed by carbonic anhydrase?

Lowers H2O's pKa Signup and view all the answers

What is the mechanism by which His 64 facilitates the reaction in carbonic anhydrase?

Moves a proton from protein surface to H2O Signup and view all the answers

Enzyme Catalysis by Approximation Quiz

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Questions and Answers

What term describes a chemical species with an affinity for a positive charge and acts as an electron donor?

Which type of effector involves the substrate binding to the allosteric site in an enzyme?

What is the term for a small organic molecule required for enzyme activity?

In covalent catalysis, what does the enzyme form temporarily with the substrate to catalyze the reaction?

What term describes the released energy when weak interactions are formed between the enzyme and substrate, promoting specificity?

Which type of effector involves a ligand binding to the allosteric site that is different from the substrate?

How is metal ion catalysis involved in nucleophile formation?

In NMP kinase, what is the purpose of having a divalent ion-bound nucleotide as the true substrate?

How does proximity aid in catalysis in NMP kinase?

What is the role of the P-loop in NMP kinase activation?

What effect does metal ion catalysis have on serine proteases like chymotrypsin?

How does metal ion catalysis contribute to enzyme function in restriction endonucleases?

What role does carbonic anhydrase play in the reaction of CO2 to HCO3-?

How does Zn2+ contribute to the reaction catalyzed by carbonic anhydrase?

What is the mechanism by which His 64 facilitates the reaction in carbonic anhydrase?

In carbonic anhydrase, what is the function of OH-?

What is the main impact of carbonic anhydrase on the speed of the reaction?

How does carbonic anhydrase promote the regeneration of its active site?

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