5 Questions
What are the most important factors affecting the ability of Entamoeba histolytica to produce pathological changes?
Virulence of the infective strain, host resistance, host nutritional status, and bacterial infection of the colon
Which areas in the colon are most affected by Entamoeba histolytica?
Caecum, right and left colonic flexures, and sigmoid colon
What do pathogenic trophozoites of Entamoeba histolytica secrete to penetrate the epithelial lining of the large intestine?
Lytic enzymes
What is produced when necrotic contents carrying tissue forms are discharged in stools?
Flask-shaped ulcers
What complication can occur if amoebiasis extends to the appendix?
Amoebic appendicitis
Study Notes
Entamoeba histolytica Pathogenesis
- The ability of Entamoeba histolytica to produce pathological changes is influenced by factors such as the parasite's virulence, the host's immune status, and the presence of bacterial flora in the gut.
Affected Areas in the Colon
- The caecum and ascending colon are the most commonly affected areas by Entamoeba histolytica.
Penetration of Epithelial Lining
- Pathogenic trophozoites of Entamoeba histolytica secrete cysteine proteases to penetrate the epithelial lining of the large intestine.
Characteristics of Necrotic Contents
- When necrotic contents carrying tissue forms are discharged in stools, they produce a characteristic "anchovy sauce" appearance.
Complications of Amoebiasis
- If amoebiasis extends to the appendix, it can lead to acute appendicitis, a potentially life-threatening complication.
Test your knowledge of the factors influencing the ability of Entamoeba histolytica to produce pathological changes and the most affected areas in the colon. Learn about the virulence of infective strains, host resistance, nutritional status, and bacterial infections.
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