20 Questions
What happens when there is a lack of eNOS cofactors?
eNOS becomes uncoupled and produces strong oxidizing free radicals
What is the effect of endothelial NO on VSMCs?
It elicits cGMP production and relaxation of VSMCs
What is the role of ROCK inhibitor Y-27632 in diseased conditions?
It restores eNOS expression and activity
What is the consequence of eNOS knockout in mice?
Increased blood pressure and propensity to manifest exaggerated atherogenesis
What is the effect of endothelial Rho-ROCK signaling on eNOS?
It inhibits eNOS and reduces NO production
What determines the microvascular permeability?
Barrier properties of the endothelium
Which of the following agents increase microvascular permeability?
All of the above
What is the function of quiescent ECs in blood vessels?
To provide a barrier to solutes and regulate nutrient transport
What is the role of eNOS in vascular barrier function?
To control inflammation by regulating NO signaling
What is angiogenesis in the context of blood vessels?
The formation of new blood vessels from existing ones
What is the primary function of endothelial cells in capillaries?
To provide a selectively permeable barrier between the blood and tissues
What is the process by which endothelial cells form new blood vessels in response to tissue injury or increased oxygen demand?
Angiogenesis
How does nitric oxide regulate inflammation in endothelial cells?
By suppressing the expression of adhesion molecules
What is the enzyme responsible for producing nitric oxide in endothelial cells?
endothelial nitric oxide synthase (eNOS)
What is the primary mechanism by which endothelial cells regulate the movement of substances across the endothelial barrier?
Transcellular transport via transporters
What percentage of neovessel formation is driven by endothelial progenitor cells from the bone marrow?
25%
What is the leading cause of limb amputation in diabetic patients?
Impaired collateralization
Which growth factor stimulates angiogenesis, increases vascular permeability, and stimulates cell migration in endothelial and myeloid cells?
VEGF-A
What is the percentage of patients affected by critical limb ischemia?
10%
What is the process by which new lymphatic blood vessels are formed?
Lymphangiogenesis
This quiz assesses your understanding of the function of endothelial nitric oxide synthase (eNOS) and its relation to atherosclerosis. Learn about the effects of eNOS uncoupling and its implications on cardiovascular health. Evaluate your knowledge on the role of eNOS in preventing cardiac and brain ischemia.
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