Podcast
Questions and Answers
What happens when there is a lack of eNOS cofactors?
What happens when there is a lack of eNOS cofactors?
- eNOS produces antioxidants and protects cellular components
- eNOS is upregulated and collateral blood flow is increased
- eNOS becomes coupled and produces more NO
- eNOS becomes uncoupled and produces strong oxidizing free radicals (correct)
What is the effect of endothelial NO on VSMCs?
What is the effect of endothelial NO on VSMCs?
- It has no effect on VSMCs
- It elicits cGMP production and relaxation of VSMCs (correct)
- It inhibits cGMP production and contraction of VSMCs
- It causes contraction of VSMCs
What is the role of ROCK inhibitor Y-27632 in diseased conditions?
What is the role of ROCK inhibitor Y-27632 in diseased conditions?
- It downregulates eNOS expression and activity
- It inhibits eNOS expression and activity
- It has no effect on eNOS expression and activity
- It restores eNOS expression and activity (correct)
What is the consequence of eNOS knockout in mice?
What is the consequence of eNOS knockout in mice?
What is the effect of endothelial Rho-ROCK signaling on eNOS?
What is the effect of endothelial Rho-ROCK signaling on eNOS?
What determines the microvascular permeability?
What determines the microvascular permeability?
Which of the following agents increase microvascular permeability?
Which of the following agents increase microvascular permeability?
What is the function of quiescent ECs in blood vessels?
What is the function of quiescent ECs in blood vessels?
What is the role of eNOS in vascular barrier function?
What is the role of eNOS in vascular barrier function?
What is angiogenesis in the context of blood vessels?
What is angiogenesis in the context of blood vessels?
What is the primary function of endothelial cells in capillaries?
What is the primary function of endothelial cells in capillaries?
What is the process by which endothelial cells form new blood vessels in response to tissue injury or increased oxygen demand?
What is the process by which endothelial cells form new blood vessels in response to tissue injury or increased oxygen demand?
How does nitric oxide regulate inflammation in endothelial cells?
How does nitric oxide regulate inflammation in endothelial cells?
What is the enzyme responsible for producing nitric oxide in endothelial cells?
What is the enzyme responsible for producing nitric oxide in endothelial cells?
What is the primary mechanism by which endothelial cells regulate the movement of substances across the endothelial barrier?
What is the primary mechanism by which endothelial cells regulate the movement of substances across the endothelial barrier?
What percentage of neovessel formation is driven by endothelial progenitor cells from the bone marrow?
What percentage of neovessel formation is driven by endothelial progenitor cells from the bone marrow?
What is the leading cause of limb amputation in diabetic patients?
What is the leading cause of limb amputation in diabetic patients?
Which growth factor stimulates angiogenesis, increases vascular permeability, and stimulates cell migration in endothelial and myeloid cells?
Which growth factor stimulates angiogenesis, increases vascular permeability, and stimulates cell migration in endothelial and myeloid cells?
What is the percentage of patients affected by critical limb ischemia?
What is the percentage of patients affected by critical limb ischemia?
What is the process by which new lymphatic blood vessels are formed?
What is the process by which new lymphatic blood vessels are formed?
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