Endocrinology Quiz - Questions E1 to E6
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Questions and Answers

Which drug does not cause hypoglycaemia in the elderly?

  • Tolbutamide
  • Acarbose (correct)
  • Repaglinide
  • Glyburide
  • In primary hyperaldosteronism, which of the following is seen?

  • Metabolic acidosis, high renin
  • Metabolic alkalosis, high renin
  • Metabolic alkalosis, low renin (correct)
  • Metabolic acidosis, low renin
  • Diabetic man with recent onset of diarrhoea and fecal incontinence. He also has a 1 year history of constipation. The most likely cause of his symptoms is:

  • Coccidiomycosis
  • Inflammatory bowel disease
  • Autonomic neuropathy (correct)
  • Colon cancer
  • Woman with Cushing's syndrome. Cortisol does not suppress with low dose dexamethasone test but does suppress with high dose test. Diagnosis:

    <p>Ectopic ACTH</p> Signup and view all the answers

    Woman with known Hx of DM I and hypothyroidism presents with weakness, dizziness, weight loss and orthostatic drop in BP. Normal TSH and HbA1c is 0.07. Next step:

    <p>ACTH stimulation test</p> Signup and view all the answers

    20 year old woman with a 2 year history of hirsuitism and oligomenorrhoea. DHEA and 17-OH progesterone both elevated. Normal testosterone, LH, FSH and overnight dexamethasone suppression test. Normal pelvic exam. Treatment:

    <p>Spironolactone</p> Signup and view all the answers

    18 year old male with gynaecomastia, chest pain, fatigue, and loss of retrosternal airspace on CXR. Diagnosis:

    <p>Thymoma</p> Signup and view all the answers

    25 year old male with hypokalaemia, bicarbonate of 28 and urine chloride of 40. Diagnosis:

    <p>Primary hyperaldosteronism</p> Signup and view all the answers

    Cushingoid female who's serum cortisol does not suppress with low dose dexamethasone. Low serum ACTH. Next step:

    <p>MRI pituitary</p> Signup and view all the answers

    18 year old male with DKA. Initial pH 6.96, glucose 28. Given 2 L NS over 2 hours, 10 units of IV insulin bolus then 3 units per hour. Now pH is 7.01 and glucose is 23. Next step:

    <p>Double the insulin rate</p> Signup and view all the answers

    60 year old male with DM II on human NPH 50 units q AM. Nocturia, morning BS 10, elevated HbA1c. Next step:

    <p>Add 10 units NPH at night</p> Signup and view all the answers

    Which is true regarding the treatment of Graves' disease?

    <p>Radioactive iodine has a low but significant risk for malignancy</p> Signup and view all the answers

    28yF 19 weeks pregnant. Diagnosed with Graves' disease. Treatment:

    <p>PTU 100 mg bid</p> Signup and view all the answers

    In the setting of primary hyperparathyroidism you would expect:

    <p>Increased PTH, high urinary calcium</p> Signup and view all the answers

    Elderly patient diagnosed with Paget's disease. Most appropriate management option:

    <p>Analgaesics and bisphosphonates</p> Signup and view all the answers

    26 year old diabetic with BP 130/80, microalbuminuria. No overt proteinuria. Treatment:

    <p>Start ACEi</p> Signup and view all the answers

    Elderly male with longstanding diabetes which is poorly controlled presents with right buttock and thigh pain and has quadriceps and thigh muscle wasting. He also complains of fatigue and weight loss. He has:

    <p>Diabetic neuropathy</p> Signup and view all the answers

    Young woman with ulcerative colitis, not responding to 5-ASA. You want to start corticosteroids. The following is true about steroid use:

    <p>Bisphosphonates decrease the risk of vertebral fractures</p> Signup and view all the answers

    The following is true with respect to osteomalacia:

    <p>Usually presents with decreased calcium and increased ALP and PO4</p> Signup and view all the answers

    Old woman with lumbar fracture and past history of breast cancer. On vitamin D and Calcium. What treatment would you start now?

    <p>Alendronate</p> Signup and view all the answers

    Back pain, x-rays showing osteopaenic spine, scapula with linear radioluscencies (Looser zones). Ca 2.10, Pi 0.75, ALP 125. This is most in keeping with:

    <p>Coeliac disease</p> Signup and view all the answers

    Type II diabetic. Best indication to use insulin:

    <p>Retinopathy</p> Signup and view all the answers

    A patient with diabetes has hypertension ~180/90. No proteinuria. What should be the target blood pressure?

    <p>130/70</p> Signup and view all the answers

    A 58yF falls and suffers a vertebral compression fracture. BMD confirms osteoporosis. Prior TAH/BSO at age 40. Prior DVT. Pain controlled with Tylenol. Best treatment:

    <p>Bisphosphonate</p> Signup and view all the answers

    Study Notes

    Endo Questions - E1

    • Acarbose does not cause hypoglycemia in the elderly
    • Repaglinide, Glyburide, and Tolbutamide do cause hypoglycemia in the elderly

    Endo Questions - E2

    • Primary hyperaldosteronism is associated with metabolic alkalosis and low renin.

    Endo Questions - E3

    • Inflammatory bowel disease is the most likely cause of diarrhoea, fecal incontinence and constipation in a diabetic man

    Endo Questions - E4

    • In Cushing's syndrome, cortisol does not suppress with low-dose dexamethasone, but does suppress with high-dose dexamethasone. Adrenal adenoma is the diagnosis.

    Endo Questions - E5

    • The next step in a diabetic female with hypothyroidism presenting with weakness, dizziness and weight loss is to perform a dexamethasone suppression test.

    Endo Questions - E6

    • In a 20 year old female with hirsuitism and oligomenorrhea, elevated DHEA and 17-OH-progesterone, but normal testosterone, LH, FSH and overnight dexamethasone suppression test, the treatment is oral contraceptive pill.

    Endo Questions - E7

    • A 18 year old male with gynaecomastia, chest pain, fatigue and retrosternal airspace on CXR is most likely to have thymoma.

    Endo Questions - E8

    • Primary hyperaldosteronism is the diagnosis for a 25 year old male with hypokalaemia, bicarbonate of 28 and urine chloride of 40

    Endo Questions - E9

    • If a Cushingoid female has low serum ACTH and their cortisol does not suppress with low-dose dexamethasone, the next step is a 24-hour cortisol and 17-hydroxysteroid test after high-dose suppression.

    Endo Questions - E10

    • For a 18 year old male in DKA, if the initial pH is 6.96 and glucose 28, given 2 L NS over 2 hours, 10 units of IV insulin bolus then 3 units per hour. If pH is 7.01 and glucose is 23, the next step is to double the insulin rate.

    Endo Questions - E11

    • For a 60 year old male with DM II on human NPH 50 units q AM, with nocturnal, elevated HbA1c. The next step is to add 10 units of NPH at night.

    Endo Questions - E12

    • Radioactive iodine can result in remission in Graves' disease, and ophthalmopathy is an indication for urgent thyroidectomy.

    Endo Questions - E13

    • The treatment for a pregnant female with Graves' disease is a beta-blocker.

    Endo Questions - E14

    • In primary hyperparathyroidism, increased PTH and high urinary calcium is expected.

    Endo Questions - E15

    • Analgaesics and bisphosphonates are the most appropriate management for Paget's disease in the elderly.

    Endo Questions - E16

    • Start ACEi for a 26 year old diabetic with BP 130/80, microalbuminuria and no overt proteinuria

    Endo Questions - E17

    • Diabetic neuropathy is the possible cause for an elderly male with longstanding poorly controlled diabetes with right buttock and thigh pain

    Endo Questions - E18

    • Bisphosphonates do not decrease the risk of vertebral fractures, and they would not inevitably lead to osteoporosis in the long term.

    Endo Questions - E19

    • Osteomalacia is usually due to dietary calcium deficiency.

    Endo Questions - E20

    • Old women with a lumbar fracture and prior breast cancer should be given Alendronate

    Endo Questions - E21

    • Coeliac disease, in conjunction with low calcium, phosphate and high ALP, is most likely the cause of low bone density

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    Description

    Test your knowledge in endocrinology with a series of focused questions covering conditions such as diabetes, Cushing's syndrome, and hyperaldosteronism. Evaluate your understanding of symptoms, treatments, and diagnostic tests. Perfect for students and professionals in the medical field looking to refresh their knowledge.

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