Hypothyroidism and Diabetes Management

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Questions and Answers

An APN is assessing an older adult diagnosed with Alzheimer's disease. Which of the following manifestations is LEAST likely to be seen in this client?

  • Difficulty with word finding
  • Impaired judgment
  • Personality changes
  • Sudden onset of confusion (correct)

How does delirium differ from dementia?

  • Delirium is a chronic, irreversible condition, while dementia is acute and reversible.
  • Delirium primarily affects memory, while dementia affects attention.
  • Delirium is characterized by a fluctuating course and altered level of consciousness, while dementia has a gradual onset and progressive decline. (correct)
  • There is no significant difference; the terms are interchangeable.

Which of the following is NOT a typical characteristic of delirium in an elderly patient?

  • Gradual and insidious cognitive decline (correct)
  • Impaired attention and focus
  • Fluctuating levels of consciousness
  • Acute onset of symptoms

When treating an older adult with Alzheimer's disease, which class of medications offers the most benefit for cognitive symptoms?

<p>Cholinesterase inhibitors (C)</p> Signup and view all the answers

When managing a patient with dementia, what benefit do cholinesterase inhibitors provide?

<p>Improve memory and cognitive function (B)</p> Signup and view all the answers

Which test would be most appropriate for the initial assessment of an elderly patient presenting with memory problems, specifically to gather insight on the patient's abilities at home?

<p>Functional Activities Questionnaire (FAQ) (C)</p> Signup and view all the answers

Which of the following assessments is LEAST likely to be included as part of the nurse practitioner’s assessment for Alzheimer's disease?

<p>Pupillary response to light (A)</p> Signup and view all the answers

A 60-year-old patient with moderate cognitive deficits due to Alzheimer's disease has been started on a cholinesterase inhibitor. What best describes the primary goal of this medication in this scenario?

<p>To provide a temporary improvement in cognitive function and daily living activities. (B)</p> Signup and view all the answers

Which laboratory assay is most sensitive for screening an ambulatory patient for primary hypothyroidism?

<p>TSH (Thyroid Stimulating Hormone) (A)</p> Signup and view all the answers

Bariatric surgery is generally recommended for patients with what condition?

<p>BMI &gt; 35 kg/m² with one or more obesity-related comorbidities (C)</p> Signup and view all the answers

Which of the following is NOT a diagnostic criterion for metabolic syndrome?

<p>Hyperthyroidism (C)</p> Signup and view all the answers

In patients with metabolic syndrome, what would be an expected finding?

<p>Elevated triglycerides (B)</p> Signup and view all the answers

Meglitinide analogs (Prandin) are used in type 2 diabetes to minimize the risk of what?

<p>Postprandial hyperglycemia (D)</p> Signup and view all the answers

An Advanced Practice Nurse (APN) is determining the appropriate T4 replacement dosage for a 35-year-old hypothyroid woman. Which patient factor is MOST critical for the APN to consider in order to establish a euthyroid state?

<p>Patient's weight in kilograms (D)</p> Signup and view all the answers

A 40-year-old patient with newly diagnosed type 2 DM is on metformin 1000 mg BID, but their latest HbA1c is 8.1%. What is the most appropriate next step?

<p>Add a second oral hypoglycemic agent (C)</p> Signup and view all the answers

A patient is suspected of having hypothyroidism. Which of the following laboratory findings is MOST indicative of this condition?

<p>Elevated TSH and low free T4 (B)</p> Signup and view all the answers

In the progression of hypothyroidism, which change in hormone levels typically occurs FIRST?

<p>Decrease in serum free T4 concentration (B)</p> Signup and view all the answers

An active 72-year-old patient with type 2 DM is on metformin 500 mg BID with HbA1c of 7.4%. The patient feels well and has no symptoms. What would you recommend?

<p>Maintain current treatment and monitor (A)</p> Signup and view all the answers

A 42-year-old diabetic patient is on metformin and a sulfonylurea with well-controlled HbA1c of 6.5%, but is complaining of dizziness and low blood sugar episodes. Which change is most appropriate?

<p>Reduce the dose of the sulfonylurea (D)</p> Signup and view all the answers

After initiating thyroid replacement therapy, when is the OPTIMAL time to measure TSH levels to assess the effectiveness of the treatment?

<p>4-6 weeks (D)</p> Signup and view all the answers

A 75-year-old patient, weighing 155 pounds and with no significant medical history, is diagnosed with hypothyroidism. Which of the following is the MOST appropriate initial starting dose of levothyroxine?

<p>25-50 mcg daily (C)</p> Signup and view all the answers

A 70-year-old woman presents with weight loss, palpitations, and constipation. Her TSH is 0.03 mIU/L (reference range: 0.4-4.0 mIU/L) and free T4 is 33 pmol/L (reference range: 9-25 pmol/L). What is the MOST appropriate next step in evaluating her thyroid function?

<p>Order a radioactive iodine uptake and scan. (A)</p> Signup and view all the answers

A patient with known hypothyroidism has been stable on levothyroxine for several years. They start taking an iron supplement for iron deficiency anemia. How should their levothyroxine dosage be adjusted?

<p>Increase the levothyroxine dosage, as iron can interfere with levothyroxine absorption. (B)</p> Signup and view all the answers

Which of the following symptoms, if present in a patient already diagnosed with hypothyroidism and on thyroid replacement therapy, would raise suspicion for poor medication adherence or inadequate dosage?

<p>Fatigue and constipation (A)</p> Signup and view all the answers

Why is Metformin typically discontinued before and after a procedure involving contrast dye?

<p>To reduce the risk of lactic acidosis. (B)</p> Signup and view all the answers

A newly diagnosed 120 kg type 1 diabetic patient is being started on insulin. Which of the following is the MOST appropriate initial daily insulin dose?

<p>60 units (B)</p> Signup and view all the answers

Which test is LEAST useful in the initial evaluation of a patient newly diagnosed with type 2 diabetes?

<p>Complete blood count (CBC) (D)</p> Signup and view all the answers

An appropriate intervention for microalbuminuria in a patient with diabetes mellitus includes which of the following?

<p>Initiation of an ACE inhibitor or ARB. (C)</p> Signup and view all the answers

Early morning hyperglycemia without preceding nocturnal hypoglycemia is BEST described as what phenomenon?

<p>Dawn phenomenon (D)</p> Signup and view all the answers

How often should Hemoglobin A1c (HbA1c) be tested in patients with well-controlled diabetes?

<p>Every 6 months (D)</p> Signup and view all the answers

A diabetic patient on insulin experiences elevated morning blood sugar levels despite increased insulin dosages. Nighttime glucose monitoring reveals hypoglycemia at 3:00 AM. How should this phenomenon be managed?

<p>Decrease the bedtime insulin dose. (D)</p> Signup and view all the answers

A primary care nurse practitioner is deciding on an initial pharmacological treatment for an older adult male with Alzheimer's disease. Which class of medication is the most appropriate first choice?

<p>Cholinesterase inhibitors (C)</p> Signup and view all the answers

When managing a patient with dementia, which outcome is most likely to be achieved with Cholinesterase inhibitors?

<p>Modest symptomatic benefit on cognition (B)</p> Signup and view all the answers

A 65-year-old male is seen for a checkup. Which intervention represents secondary prevention in this patient?

<p>Scheduling a colonoscopy to screen for colon cancer. (A)</p> Signup and view all the answers

What type of assessment provides information on the functional performance of complex activities in an elderly patient presenting with memory problems?

<p>Functional Activities Questionnaire (B)</p> Signup and view all the answers

Which of the following is LEAST likely to be included as part of a standard nurse practitioner's assessment for Alzheimer's disease?

<p>Genetic testing for specific Alzheimer's-related genes on all patients (D)</p> Signup and view all the answers

When evaluating a patient for dementia, which initial tests are the MOST appropriate to include?

<p>Complete blood count (CBC), comprehensive metabolic panel (CMP), Vitamin B12 level (B)</p> Signup and view all the answers

A 60-year-old patient with moderate cognitive deficit due to Alzheimer's disease is started on a cholinesterase inhibitor. What is the primary purpose of this medication?

<p>To improve cognitive function temporarily (C)</p> Signup and view all the answers

A patient presents with an elevated thyroid-stimulating hormone (TSH) level and a normal thyroxine (T4) level. Which condition is the MOST likely diagnosis?

<p>Subclinical hypothyroidism (C)</p> Signup and view all the answers

Which of the following are established criteria for the diagnosis of type 2 diabetes mellitus?

<p>Fasting plasma glucose ≥ 126 mg/dL, A1C ≥ 6.5%, and Symptoms of hyperglycemia (A)</p> Signup and view all the answers

A 72-year-old male with hypertension is prescribed amlodipine 5mg daily, lisinopril 5mg daily, and enalapril 5mg daily. Which guideline, applicable to this regimen according to Beers and STOPP criteria, would prompt consideration of deprescribing a medication?

<p>Beers criteria suggest avoiding concurrent use of multiple ACE inhibitors (lisinopril, enalapril) due to increased risk of hyperkalemia and hypotension. (B)</p> Signup and view all the answers

An 81-year-old patient on seven medications is suspected of medication non-adherence due to forgetfulness. What is the MOST effective initial intervention?

<p>Simplify the medication regimen by consolidating medications or reducing the number of doses per day, in collaboration with the provider. (C)</p> Signup and view all the answers

A 78-year-old patient scores 22 on an MMSE during an annual physical. How should this result be interpreted?

<p>Indicates possible moderate cognitive impairment, warranting further evaluation. (A)</p> Signup and view all the answers

A 76-year-old male received a Td immunization six years ago and a flu shot in November. He has no record of other vaccinations. Which TWO immunizations should the nurse practitioner recommend?

<p>Zoster Vaccine Recombinant (Shingrix) (C), Pneumococcal Vaccines (PPSV23 or PCV15/PCV20) (D)</p> Signup and view all the answers

An 80-year-old woman has experienced two falls in the past year. Which of the following is the MOST appropriate initial intervention for fall prevention?

<p>Initiating a strength and balance training program, along with a review of medications. (A)</p> Signup and view all the answers

A nurse practitioner is discussing fall prevention with a 70-year-old patient. Which statement by the patient indicates a need for further teaching?

<p>&quot;It's fine for me to walk without my glasses because I know my house well.&quot; (D)</p> Signup and view all the answers

A nurse practitioner is evaluating a 77-year-old woman who recently had an unwitnessed fall. The patient reports no mobility limitations or obvious risk factors, stating, "I suddenly found myself on the floor" and did not attempt to break the fall. This statement MOST strongly suggests:

<p>The patient experienced a syncopal episode or drop attack. (D)</p> Signup and view all the answers

An APN is assessing an older adult diagnosed with Alzheimer's disease. Which assessment finding is MOST indicative of the disease progression, rather than other age-related changes?

<p>Impaired judgment and decision-making affecting daily safety. (C)</p> Signup and view all the answers

Flashcards

T4 Replacement Dosage Factors

Patient's weight in kilograms is important for determining the appropriate T4 replacement dosage.

Hypothyroidism Lab Values

High TSH and low T4 levels are common laboratory findings in hypothyroidism.

TSH Response to Low T4

When serum free T4 concentration falls, TSH levels increase.

Optimal TSH Measurement Time

6-8 weeks after initiating thyroid replacement therapy to allow TSH levels to stabilize.

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Levothyroxine Dosage

70 mcg

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Next step to evaluate the thyroid

Measure Free T3

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Alzheimer's Manifestation

Progressive cognitive decline

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Delirium vs. Dementia

Delirium has acute onset, dementia is gradual.

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Delirium Characteristic

Slow onset is NOT typical of delirium.

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Cholinesterase Inhibitors

Improve cognitive function by inhibiting acetylcholinesterase.

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Functional Assessment

Assesses ability to perform activities for daily independent living.

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Cholinesterase Inhibitor Purpose

To stabilize cognitive function.

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Subclinical Hypothyroidism

High TSH, normal T4 indicates subclinical hypothyroidism.

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Metformin & Contrast

Temporary discontinuation of Metformin is recommended to reduce the risk of contrast-induced nephropathy.

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Initial Insulin Dose (Type 1 DM)

A starting dose of 0.5 units/kg/day is commonly used for Type 1 DM patients initiating insulin therapy.

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Differentiating DM Types

C-peptide levels help differentiate between Type 1 and Type 2 DM.

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Microalbuminuria Intervention (DM)

ACE inhibitors or ARBs reduce microalbuminuria in diabetic patients.

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Dawn Phenomenon

Dawn phenomenon causes early morning hyperglycemia without preceding nocturnal hypoglycemia.

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Hgb A1C Testing Frequency

Hgb A1C should be tested at least twice a year in patients who are meeting treatment goals.

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DM Treatment Goal (A1C)

Hgb A1C <7% is generally the goal for non-pregnant adults with DM.

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Somogyi Effect Management

Somogyi effect is managed by reducing the insulin dose.

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Hypothyroidism screening lab?

TSH (Thyroid Stimulating Hormone) assay.

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Bariatric surgery criteria?

BMI ≥40 kg/m2 or BMI ≥35 kg/m2 with obesity-related comorbidities.

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Metabolic Syndrome criteria EXCEPT?

Elevated HDL cholesterol.

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Expected finding in Metabolic Syndrome?

Hypertriglyceridemia.

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Meglitinides minimize risk of?

Hypoglycemia.

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Next step for uncontrolled DM?

Add a medication from a different class (e.g., DPP-4 inhibitor, SGLT2 inhibitor).

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Management of well controlled DM?

Continue current treatment and monitor HGbA1C.

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TZD contraindication?

A woman of childbearing age NOT using contraception.

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Medication Metabolism in Elderly

Age-related changes affect how medications are metabolized, meaning processing and using drugs changes.

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Multiple Hypertension Meds

Both the BEERS criteria and STOPP criteria highlight potential issues with using multiple antihypertensives concurrently, increasing risk for hypotension.

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Medication Reconciliation

Medication reconciliation creates an accurate list of all medications a patient is taking and ensures medications are appropriately prescribed.

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MMSE Score of 22

An MMSE score of 22 suggests cognitive impairment; further evaluation is needed.

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Vaccination Recommendations (77 yr old)

Recommend pneumococcal and zoster vaccinations, given his age and vaccination history.

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Fall prevention

Recommended interventions are exercise programs.

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Fall Prevention understanding

Further teaching is needed when the patient states that limiting exercise to prevent muscle strain is an effective method for fall prevention.

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Unexpected Fall - Syncope

Loss of balance or sudden fall without attempting to break the fall suggest syncope due to a cardiac cause.

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Initial Alzheimer's drug choice

Cholinesterase inhibitors are typically the initial choice for managing Alzheimer's disease in older adults.

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Cholinesterase inhibitor benefit

Cholinesterase inhibitors offer benefits in managing dementia symptoms.

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Memory problem assessment

Assess functional performance of complex activities in elderly patients with memory problems.

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High TSH, normal T4

Elevated TSH with normal T4 indicates subclinical hypothyroidism.

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Type 2 diabetes diagnosis

Criteria include elevated fasting plasma glucose, HbA1c, and classic symptoms with random glucose.

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Donepezil

Donepezil is often the first-line treatment, improving cognitive function by inhibiting acetylcholinesterase, increasing acetylcholine levels in the brain.

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Study Notes

  • A 35-year-old woman has hypothyroidism, the APN considers the patient's PT weight in kg to determine T4 replacement needed for a euthyroid state.
  • Hypothyroidism commonly presents with high TSH and low T4 levels.
  • In hypothyroidism, TSH levels increase when serum free T4 concentration falls.
  • TSH is best measured after initiating thyroid replacement therapy.
  • A 75-year-old patient with hypothyroidism, weighing 155 pounds, needs medication and appropriate dosage.
  • A 70-year-old woman with weight loss, palpitations, constipation, TSH: 0.03, T4: 33 requires further thyroid evaluation.
  • Meglitinide analogs (Prandin) are helpful in type 2 diabetes to minimize risk.
  • A 40-year-old newly diagnosed type 2 DM patient on metformin 1000 mg BID, with HbA1c of 8.1%, requires the next appropriate step.
  • A TZD drug can be prescribed depending on the patient.
  • For a 42-year-old diabetic patient on metformin and sulfonylurea with HbA1c of 6.5% complaining of dizziness with episodes of low blood sugar, changes would be appropriate.
  • A 55-year-old type 2 DM patient maximizing two oral medications, HbA1c 9.8%, weight 120 kg requires the next step.
  • A 38-year-old female in good health with a strong family history of type 2 DM and symptoms of polydipsia, polyuria, and polyphagia, with a fasting blood glucose of 285.
  • For a 45-year-old patient, diabetic for five years, on metformin with elevated fasting glucose and HbA1c of 8.2%, consider adding a second oral medication.
  • For Dan, who is 45 years old, obese and has type 2 DM with difficulty getting his HGbA1C under control, an appropriate response would be to GLP-1 receptor agonist(Byetta) cause weight loss.
  • Metformin should be discontinued the day of and up to 48 hours after surgery or a procedure with contrast due to the increased risk.
  • Intervention for microalbuminuria for a person with DM requires medical intervention.
  • Early morning increase in blood sugar, with no corresponding hypoglycemia during the night: this phenomenon needed to be tested.
  • HbA1c should be tested based on medical guidelines.
  • The maintenance goal of DM treatment in most non-pregnant adults required.
  • A test is needed to differentiate between type one and type 2 DM.
  • For a diabetic patient on insulin with elevated morning blood sugar despite increased insulin, checking glucose in the middle of the night (3:00 AM) and managing accordingly would be useful
  • For a 72-year-old male diagnosed with hypertension, with BP at 134/82 and with no complaints, taking amlodipine 5 mg daily, lisinopril 5 mg daily, and enalapril 5 mg daily, stopping one medication should be considered.
  • An MMSE score of 22 requires that the patient be assessed.
  • For a 60-year-old patient with moderate cognitive deficit attributed to Alzheimer's disease, the purpose of this Cholinesterase inhibitor is to promote memory and thinking.
  • A patient with high TSH and normal T4 requires and appropriate diagnosis.
  • An APN assessing an older adult with Alzheimer's disease will determine the patient's capabilities.
  • Delirium differs from dementia.
  • With dementia, cholinesterase inhibitors offer the greatest benefit.
  • The appropriate initial test includes tests that apply to dementia.

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