Endocrinology Quiz on Hormones
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Questions and Answers

Which hormone is a mineralocorticoid produced by the adrenal cortex?

  • Testosterone
  • Aldosterone (correct)
  • Estrogen
  • Cortisol
  • What is the primary precursor for all steroid hormones?

  • Cortisol
  • Testosterone
  • Cholesterol (correct)
  • Insulin
  • Which class of hormones includes insulin and growth hormone?

  • Peptides (correct)
  • Thyroid hormones
  • Amines
  • Steroids
  • What does the adrenal medulla primarily secrete?

    <p>Catecholamines (C)</p> Signup and view all the answers

    Which hormone is produced only by the gonads?

    <p>Testosterone (A)</p> Signup and view all the answers

    What is the fate of water-soluble hormones in the bloodstream?

    <p>They are found as free form in blood. (A)</p> Signup and view all the answers

    Which of the following is a glucocorticoid produced by the adrenal cortex?

    <p>Cortisol (B)</p> Signup and view all the answers

    Which protein is primarily responsible for binding thyroid hormones in the blood?

    <p>Thyroid-binding globulin (TBG) (A)</p> Signup and view all the answers

    What hormone primarily stimulates the adrenal medulla to release cortisol?

    <p>Adrenocorticotropic Hormone (ACTH) (C)</p> Signup and view all the answers

    What is the role of cortisol in the hypothalamic-pituitary-adrenal (HPA) axis?

    <p>Inhibiting the synthesis of ACTH (C)</p> Signup and view all the answers

    Which of the following is a direct effect of increased cortisol levels in the body?

    <p>Increased glycogenolysis in the liver (B)</p> Signup and view all the answers

    Where is corticotropin releasing hormone (CRH) synthesized?

    <p>Paraventricular region of the hypothalamus (B)</p> Signup and view all the answers

    What is one consequence of the negative feedback loop in the HPA axis?

    <p>Inhibition of ACTH synthesis (A)</p> Signup and view all the answers

    In addition to ACTH, what other hormones are produced from the cleavage of proopiomelanocortin (POMC)?

    <p>α-MSN and β-endorphin (B)</p> Signup and view all the answers

    What physiological effect does increased lipolysis have in the body during stress?

    <p>Increased energy availability from stored fats (A)</p> Signup and view all the answers

    Which part of the brain primarily processes inputs to release CRH?

    <p>Limbic system (C)</p> Signup and view all the answers

    What is the primary mechanism by which T3 exerts its effects in target tissues?

    <p>By altering gene expression after binding to nuclear receptors (B)</p> Signup and view all the answers

    Which hormone is primarily responsible for stimulating the release of TSH?

    <p>Thyrotropin-releasing hormone (TRH) (C)</p> Signup and view all the answers

    What effect does TSH have on the thyroid gland?

    <p>Promotes the uptake of thyroglobulin into thyroid cells (D)</p> Signup and view all the answers

    Which of the following symptoms is associated with hyperthyroidism?

    <p>Increased basal metabolic rate (BMR) (A)</p> Signup and view all the answers

    Elevated levels of TRH can disrupt which of the following systems?

    <p>Reproductive system (B)</p> Signup and view all the answers

    What is the condition of goiter primarily related to?

    <p>Both hyperthyroid and hypothyroid conditions (A)</p> Signup and view all the answers

    What happens to T4 once it enters tissues?

    <p>It is converted to T3 by deiodinase (C)</p> Signup and view all the answers

    Which of the following statements about the regulation of thyroid hormones is true?

    <p>Thyroid hormones exert negative feedback on TSH production (C)</p> Signup and view all the answers

    What is the primary hormone responsible for calcium homeostasis in the body?

    <p>Parathyroid hormone (PTH) (C)</p> Signup and view all the answers

    Which type of bone makes up 80% of total bone mass and is known for its density and strength?

    <p>Cortical bone (C)</p> Signup and view all the answers

    Which bone cell is responsible for the resorption of bone?

    <p>Osteoclasts (B)</p> Signup and view all the answers

    What percentage of total body calcium is stored in bones?

    <p>99% (A)</p> Signup and view all the answers

    Which component forms the organic matrix of bone?

    <p>Osteoid (A)</p> Signup and view all the answers

    How does the balance between osteoclast and osteoblast activity influence plasma calcium concentrations?

    <p>The balance determines calcium release and uptake, influencing plasma levels. (B)</p> Signup and view all the answers

    What role does calcitonin play in calcium regulation?

    <p>It plays a minor role in regulating plasma calcium levels. (A)</p> Signup and view all the answers

    What percentage of bone is composed of hydroxyapatite?

    <p>60% (C)</p> Signup and view all the answers

    What occurs at the edge of the growth plate during bone development?

    <p>Osteoblasts convert cartilage to bone (B)</p> Signup and view all the answers

    During which developmental stage does brain growth primarily occur?

    <p>Fetal stage (D)</p> Signup and view all the answers

    Which nutrient type is essential for normal growth?

    <p>Essential fatty acids (C)</p> Signup and view all the answers

    What impact does malnutrition during infancy have on growth?

    <p>It leads to decreased growth and development (D)</p> Signup and view all the answers

    What is the most important hormone for postnatal growth?

    <p>Growth hormone (B)</p> Signup and view all the answers

    What occurs when growth hormone stimulates the release of IGF-1?

    <p>Cell division is stimulated (A)</p> Signup and view all the answers

    Which factor can temporarily stunt growth but usually results in a growth spurt upon recovery?

    <p>Sickness (D)</p> Signup and view all the answers

    Which of the following statements about stress and growth is accurate?

    <p>Stress impairs growth (B)</p> Signup and view all the answers

    What effect does high levels of cortisol have on DNA synthesis?

    <p>Inhibits DNA synthesis (A)</p> Signup and view all the answers

    What condition is characterized by excess growth hormone before puberty?

    <p>Gigantism (D)</p> Signup and view all the answers

    How does growth hormone deficiency affect growth if it occurs before puberty?

    <p>Inhibited growth (A)</p> Signup and view all the answers

    What is the effect of high levels of growth hormone on the rate of bone maturation?

    <p>Accelerated bone maturation (B)</p> Signup and view all the answers

    What is the primary result of thyroid deficiency on growth rate?

    <p>Very slow growth rate (B)</p> Signup and view all the answers

    Which effect is commonly associated with excess growth hormone after the closure of epiphyseal growth plates?

    <p>Increase in bone thickness (C)</p> Signup and view all the answers

    What impact does cortisol have on protein catabolism?

    <p>Stimulates protein catabolism (B)</p> Signup and view all the answers

    What clinical condition is associated with a lack of sex steroids?

    <p>Tall-eunichoid (C)</p> Signup and view all the answers

    Flashcards

    Catecholamines

    A class of hormones, including dopamine, norepinephrine, and epinephrine, that are derived from tyrosine.

    Steroid Hormones

    Hormones derived from cholesterol, characterized by their lipid solubility.

    Mineralocorticoids

    A type of steroid hormone, important for regulating salt and water balance.

    Glucocorticoids

    A class of steroid hormones, crucial for regulating blood sugar and metabolism.

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    Peptide Hormones

    Hormones composed of chains of amino acids, mostly water-soluble.

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    Hormone Transport (Water-soluble)

    Travel freely in the bloodstream (as free form).

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    Hormone Transport (Lipid-soluble)

    Travel bound to proteins in the blood.

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    Adrenal Gland

    The gland located above the kidney, producing hormones such as cortisol and aldosterone.

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    Shunting of blood

    Redirection of blood flow from internal organs (like the digestive system) to skeletal muscles during stress or exercise. This ensures that muscles receive adequate oxygen and nutrients for increased activity.

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    Decreased GI motility

    Slowing down of the digestive process during stress. This conserves energy and resources for immediate needs.

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    Renal retention of sodium and water

    The kidneys hold onto sodium and water during stress, increasing blood volume and pressure to support increased blood flow to muscles.

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    Increased glycogenolysis

    Breakdown of glycogen stored in the liver and muscles, releasing glucose to provide immediate energy during stress or exercise.

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    Increased gluconeogenesis

    The process of creating glucose from non-carbohydrate sources (like amino acids) in the liver to maintain blood sugar levels during stress.

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    Increased lipolysis

    Breakdown of fat stores to release fatty acids, which can be used as fuel for energy production during extended stress or exercise.

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    CRH (Corticotropin-Releasing Hormone)

    A hormone released by the hypothalamus in response to stress. It signals the pituitary gland to release ACTH.

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    ACTH (Adrenocorticotropic Hormone)

    A hormone released by the pituitary gland in response to CRH. ACTH travels to the adrenal glands and stimulates the release of cortisol.

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    Thyroid hormone transport

    Most T3 and T4 circulate bound to proteins in plasma, primarily thyroid-binding globulin (TBG), albumin, and transthretin. This binding ensures their stability and prevents rapid breakdown.

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    T3 intracellular action

    T3 enters cells and binds to its receptor inside the nucleus. This complex then binds to DNA, altering gene expression and influencing various metabolic processes.

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    HPT Axis: TRH

    Thyrotropin-releasing hormone (TRH) is secreted by the hypothalamus, stimulating the release of TSH by the pituitary gland. It also influences prolactin release.

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    TSH action

    Thyroid stimulating hormone (TSH) increases thyroid gland activity by stimulating thyroglobulin uptake, T3 and T4 release, thyroid cell growth, iodine metabolism, and overall thyroid gland metabolism.

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    Hyperthyroidism symptoms

    Increased Basal Metabolic Rate (BMR) with weight loss, enlarged thyroid gland (goiter), heat intolerance, excessive sweating, emotional lability, and potentially difficulty swallowing or breathing due to thyroid gland enlargement.

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    Hyperthyroidism: TSH levels

    In hyperthyroidism, the thyroid gland produces excessive thyroid hormones, leading to low TSH levels. This is because a negative feedback loop is triggered.

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    Goiter

    Enlargement of the thyroid gland, observed in both hyperthyroid and hypothyroid states, indicating thyroid gland dysfunction.

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    Hyperthyroidism: Iodine levels

    Iodine levels are generally normal in hyperthyroidism. The gland uses iodine efficiently but still overproduces thyroid hormones.

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    Bone's Role in Calcium

    Bone serves as the primary storage site for calcium (Ca2+) and phosphate in the body.

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    Parathyroid Hormone (PTH)

    The main hormone responsible for maintaining calcium balance in the blood. It increases calcium levels by promoting its release from bone and absorption in the gut.

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    Calcitriol (Vitamin D3)

    A hormone that aids in calcium absorption from the gut, thereby increasing blood calcium levels.

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    Calcitonin

    A hormone that lowers blood calcium levels by reducing bone resorption. It plays a lesser role compared to PTH.

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    Compact Bone

    The dense outer layer of bone, making up 80% of bone mass. Strong and rigid, it provides structural support and bears weight.

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    Spongy Bone

    The inner, less dense layer of bone, making up 20% of bone mass. It is light and porous, allowing it to withstand compressive forces.

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    Osteoblasts

    Bone-building cells that synthesize and secrete bone matrix, forming new bone tissue.

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    Osteoclasts

    Bone-resorbing cells that break down bone tissue, releasing calcium and phosphate into the blood.

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    Growth Plate Closure

    The process of the epiphyseal plate being converted to bone, ending longitudinal growth.

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    Brain Growth vs. Bone Growth

    Brain growth occurs primarily in early childhood while bone growth occurs later in life.

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    Growth Stages

    Human growth occurs in three main stages - fetal, postnatal, and puberty.

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    Nutritional Needs for Growth

    Growth requires essential amino acids, fatty acids, vitamins, minerals, and energy-providing nutrients like carbohydrates and protein.

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    Early Malnutrition's Impact

    Malnutrition during infancy and early childhood can lead to stunted growth and impaired cognitive development.

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    Growth Hormone's Main Role

    The most important hormone for postnatal growth, stimulating cell division and bone lengthening.

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    IGF-1's Connection to Growth Hormone

    Growth hormone stimulates the release of IGF-1 (Insulin-like Growth Factor-1), which mediates most of its growth-promoting effects.

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    Growth Hormone's Anti-Insulin Effects

    Growth hormone can stimulate lipolysis, gluconeogenesis, and reduce insulin-induced glucose uptake.

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    Cortisol's anti-growth effects

    High doses of cortisol inhibit growth by suppressing DNA synthesis, promoting protein breakdown, hindering bone growth, causing bone resorption, and interfering with growth hormone release.

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    Gigantism

    Excessive growth hormone production before puberty, resulting in increased bone length.

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    Acromegaly

    Excessive growth hormone production after puberty, leading to thickened bones and enlarged soft tissues (hands, feet, head).

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    Growth Hormone Deficiency

    Lack of growth hormone, leading to stunted growth before puberty and minimal clinical symptoms in adults.

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    Growth hormone release pattern

    Growth hormone is released most during adolescence and declines with age.

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    Growth Hormone Treatment: Children

    Growth hormone therapy is used to treat growth deficiencies in children.

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    Growth Hormone Treatment: Elderly

    Growth hormone therapy may be used in elderly patients to improve muscle mass and bone density.

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    Growth Hormone Treatment: Athletes

    Growth hormone is banned in sports due to its potential for performance enhancement.

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    Study Notes

    Introduction to Endocrine Physiology

    • Hormones are transported in the blood. Some are bound to proteins, which affects their action.
    • Hormone receptors have different types, each binding to specific hormones.
    • The hypothalamic-pituitary axis (HPA) is made up of the hypothalamus, anterior pituitary, and posterior pituitary.
    • The anterior pituitary releases hormones that regulate other endocrine glands.
    • Negative feedback regulation controls the release of these anterior pituitary hormones.

    Overview of Endocrinology

    • The endocrine system is a major communication system in the body.
    • Endocrine glands are not anatomically connected.
    • Hormone action is specific due to receptors on the target tissues.
    • Hormone responses vary in speed, from seconds to days.
    • Hormone concentrations are very low in plasma (10⁻⁹ M to 10⁻¹² M).

    Hormones from Previous Lectures

    • Epinephrine and norepinephrine are related to the autonomic nervous system.
    • Atrial natriuretic peptide (ANP) is related to the cardiovascular system.
    • The gastrointestinal system includes hormones like gastrin, secretin, cholecystokinin, and motilin.
    • Renin-angiotensin, aldosterone, parathyroid hormone, vitamin D, and antidiuretic hormone (ADH) are all components of the renal system.

    Chemical Classification of Hormones

    • Amines—derived from the amino acid tyrosine, including catecholamines (dopamine, norepinephrine, epinephrine, from adrenal medulla).
    • Steroids—derived from cholesterol, including mineralocorticoids (aldosterone), glucocorticoids (cortisol), and sex steroids.
    • Peptides—polypeptide chains, such as proopiomelanocortin (POMC) and insulin.

    Thyroid Hormone

    • 3,5,3',5'-Tetraiodothyronine (thyroxine, T4) and 3,5,3'-Triiodothyronine (T3) are thyroid hormones.
    • Cholesterol is the precursor to all steroid hormones.

    Steroid Secreting Glands

    • The adrenal gland (above the kidneys) is divided into cortex and medulla.
    • Cortex produces mineralocorticoids (aldosterone), glucocorticoids (cortisol), and androgens (DHEA).
    • Gonads (testes and ovaries) produce sex steroids.
    • Testes produce testosterone.
    • Ovaries produce estrogen, progesterone.
    • Placenta produces estrogen and progesterone.

    Peptide Hormones

    • Proopiomelanocortin (POMC) and insulin are examples.
    • POMC processes into other hormones (ACTH, endorphins).
    • Insulin synthesis involves preproinsulin, proinsulin, and insulin.

    Hormonal Transport in Blood

    • Water-soluble hormones (e.g., catecholamines, peptides) travel freely in blood.
    • Protein-bound hormones (e.g., steroids, thyroid hormone) are bound to transport proteins.

    Biotransformation

    • Hormones are metabolized or deactivated in the liver or kidneys.
    • Some metabolites are biologically active, while others are inactive.
    • The transformation of hormones can be activation or inactivation.

    Membrane Bound Receptors

    • Hormone binding to receptors on the plasma membrane activates intracellular signaling pathways.
    • These pathways can produce rapid effects or alter gene expression.

    Intracellular Receptors

    • Steroid hormones, thyroid hormones, and vitamin D use intracellular receptors.
    • Hormone binding to receptor activates the receptor as a transcriptional factor.

    Integration of Hormone Action

    • Hormone actions can be complementary (similar effects), antagonistic (opposite effects), or permissive (one hormone needing another).

    Control of Hormone Secretion

    • Hormones can be secreted in pulses or cyclical patterns (e.g., circadian).
    • Some hormonal releases are regulated by nutrient levels, physical stimuli, or neural control (e.g., autonomic and hypothalamic-pituitary axis).

    Anatomy of Hypothalamus and Pituitary

    • The hypothalamus regulates the release of hormones from the pituitary gland.
    • The anterior pituitary is connected to the hypothalamus by portal vessels.
    • The pituitary gland is divided into the anterior and posterior lobes.

    Posterior Pituitary

    • The posterior pituitary consists of axons and nerve endings from hypothalamic neurons.
    • The posterior pituitary releases antidiuretic hormone (ADH) and oxytocin.

    Hypothalamic-Pituitary Axis

    • Hypophysiotropic hormones from the hypothalamus control the release of anterior pituitary hormones.
    • Anterior pituitary hormones regulate other endocrine glands (tropic hormones).
    • Several hypothalamic hormones (CRH, GHRH, TRH, GnRH, DA) control the release of other hormones.

    Anterior Pituitary Hormones

    • Anterior pituitary hormones are secreted from different cell types (e.g., lactotrophs, corticotrophs, thyrotrophs, gonadotrophs, somatotrophs).

    Hormonal Feedback Control Systems

    • Negative feedback loops regulate hormone levels.
    • Downregulation occurs with excessive stimulation.
    • Upregulation occurs with insufficient stimulation.

    Endocrine Disorders

    • Primary endocrine disorders affect the gland directly.
    • Secondary endocrine disorders result from problems regulating the gland.
    • Hypo-secretion results in decreased hormone levels.
    • Hyper-secretion results in increased hormone levels.

    Introduction to Metabolism

    • Metabolism studies anabolic and catabolic processes.
    • Anabolism builds new molecules, while catabolism breaks them down for energy.
    • Key metabolic organs are liver, skeletal muscle, adipose tissue, and brain.

    Carbohydrates, Lipids, and Protein Metabolism

    • Post-prandial state is after eating and involves glucose, triglyceride, and amino acid usage.
    • Fasting state involves glycogenolysis and gluconeogenesis.
    • Proteins are metabolized for fuel and some energy creation pathways (e.g., glycolysis, Krebs cycle)
    • Lipids, especially fatty acids are metabolized through beta-oxidation.

    Absorptive State (Postprandial)

    • Briefly described as post-meal and involves the metabolic processing of carbohydrates (glucose), protein, and fats to provide energy or store the excess as fat, glycogen, and protein, including some hormone regulation.

    Fasting State (Post-absorptive)

    • Briefly described as the period between meals and involves the use of stored energy (glycogen, fat, and protein) to maintain glucose levels and provide energy, including some hormone regulation.

    Glucose-Counterregulatory Systems

    • Describes the systems acting in opposition to insulin, maintaining blood glucose levels.
    • Key hormones include glucagon (by liver), epinephrine (by adrenal medulla, effect on liver and muscles), cortisol (by adrenal cortex, effect on lipid, protein, and carbohydrate metabolism), and thyroid hormone.

    Sympathetic Control of Plasma Glucose

    • Sympathetic nervous system directs the body to increase carbohydrate and fat metabolism to provide glucose.
    • Sympathetic activation increases gluconeogenesis, glycogenolysis, and lipolysis, leading to increased plasma glucose and other metabolic substrates (e.g., fatty acids, glycerol).

    Cortisol and Growth Hormone

    • Cortisol plays a permissive role in gluconeogenesis and lipolysis in the post-absorptive period.
    • Growth hormone is responsible for stimulating protein synthesis and bone growth.
    • Their effects can be permissive or active depending on blood levels.

    Hypoglycemia and Symptoms

    • Describes the symptoms and mechanisms associated with low blood glucose (e.g., headache, confusion, dizziness).
    • Describes the cause of these symptoms, and possible triggers including insulin overdose or drugs.

    Thyroid Diseases

    • Goiter is an enlargement of the thyroid gland, possibly resulting from either hypothyroidism or hyperthyroidism.
    • Hyperthyroidism causes increased metabolic rate, weight loss despite increased appetite, intolerance to heat, emotional instability and other symptoms.
    • Hypothyroidism causes decreased metabolic rate, weight gain, intolerance to cold, and other symptoms.

    Hypothalamic-Pituitary-Adrenal (HPA) Axis

    • The HPA axis is responsible for the body's response to stress.
    • Corticotropin-releasing hormone (CRH from hypothalamus) stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH).
    • ACTH stimulates the release of cortisol from the adrenal cortex.
    • Cortisol's release is regulated by negative feedback (cortisol inhibits the release of CRH and ACTH).

    Calcium Homeostasis

    • Involved mainly in the process of regulating calcium uptake, excretion (with hormone, Vitamin D) and bone health/regrowth, including the major factors regulating blood calcium homeostasis.
    • The major regulators include parathyroid hormone (PTH), vitamin D, and calcitonin.

    Bone Remodeling

    • Explains the continuous process of bone breakdown and formation.
    • Osteoclasts break down bone, releasing calcium.
    • Osteoblasts create new bone, incorporating calcium.

    Vitamin D Synthesis and Effects

    • Vitamin D3 (cholecalciferol) is produced in the skin through UV light and obtained from foods, and is converted to 1,25 dihydroxyvitamin D3.
    • This active form regulates calcium absorption from the intestines.

    Parathyroid Hormone (PTH)

    • PTH increases blood calcium by acting on the bone, kidneys, and intestines.
    • PTH stimulates the release of calcium from the bone and the conservation of calcium by the kidneys.
    • PTH encourages the production of vitamin D to stimulate calcium absorption by the intestines.

    Calcitonin

    • Calcitonin decreases blood calcium by inhibiting bone resorption by osteoclasts.

    Growth

    • Growth hormone (GH) is a key regulator of growth, affecting bones, muscle, and other tissues.
    • Insulin plays an important role in growth—especially important during the periods of bone and cell growth, especially in adolescents.
    • Thyroid hormone is necessary for growth and brain development.
    • Sex hormones (androgens and estrogens) play a crucial role in growth spurts and bone maturation.

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    Description

    Test your knowledge on various hormones produced by the endocrine system. This quiz covers mineralocorticoids, glucocorticoids, and the role of hormones in the hypothalamic-pituitary-adrenal axis. Perfect for students studying endocrinology or related fields.

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