Endocrine System Quiz

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Questions and Answers

What is the primary way that non-steroidal hormones exert their effects on target cells?

  • By altering gene transcription directly
  • By activating nuclear receptors directly
  • By binding to receptors on the outer surface of the plasma membrane (correct)
  • By diffusing through the plasma membrane

Which of the following mechanisms is NOT a common way to regulate hormone release?

  • Humoral stimuli
  • Neural stimuli
  • Hormonal stimuli
  • Electrical stimuli (correct)

What role do G proteins play in the action of hormones on target cells?

  • They initiate gene transcription directly
  • They directly bind to hormones in the cytoplasm
  • They facilitate hormone diffusion through the plasma membrane
  • They serve as second messengers that activate enzymes (correct)

How do steroid hormones typically exert their effects on target cells?

<p>By changing plasma membrane permeability (A)</p> Signup and view all the answers

How many hormones are secreted by the anterior pituitary gland?

<p>6 (D)</p> Signup and view all the answers

Which component is involved in activating or inactivating enzymes upon hormone binding?

<p>G protein complexes (A)</p> Signup and view all the answers

Which hormone is primarily responsible for stimulating muscle and bone growth?

<p>Growth Hormone (B)</p> Signup and view all the answers

What results from low secretion of growth hormone during childhood?

<p>Dwarfism (D)</p> Signup and view all the answers

What type of feedback is most commonly associated with hormone regulation?

<p>Negative feedback (B)</p> Signup and view all the answers

What is the primary function of melatonin produced by the pineal gland?

<p>Induces drowsiness (B)</p> Signup and view all the answers

For a hormone to initiate a response in a target cell, what must be present?

<p>Specific receptors that can bind the hormone (A)</p> Signup and view all the answers

Which of the following statements about non-steroidal hormones is true?

<p>They act through second messengers after binding to receptors on the membrane (A)</p> Signup and view all the answers

Which gland is often referred to as the 'Master Endocrine Gland'?

<p>Anterior Pituitary (C)</p> Signup and view all the answers

How many hormones are produced by the hypothalamus?

<p>2 (A)</p> Signup and view all the answers

What is a result of excess growth hormone secretion in adults?

<p>Acromegaly (A)</p> Signup and view all the answers

When is melatonin production at its peak?

<p>Night (C)</p> Signup and view all the answers

What is the primary function of calcitonin?

<p>Regulates calcium ion concentrations by decreasing them (C)</p> Signup and view all the answers

Which condition is associated with the hyposecretion of TSH in childhood?

<p>Cretinism (D)</p> Signup and view all the answers

What is the consequence of a lack of iodine in the diet?

<p>Goitre (B)</p> Signup and view all the answers

Which of the following hormones is produced by the thyroid gland?

<p>Calcitonin (C)</p> Signup and view all the answers

What is the primary action of parathyroid hormone (PTH)?

<p>Increases calcium ion concentrations in the blood (B)</p> Signup and view all the answers

Which disease is characterized by hyperthyroidism and often includes exophthalmos?

<p>Graves’ disease (C)</p> Signup and view all the answers

What is the result of severely low calcium levels in the body?

<p>Muscular spasms or convulsions (D)</p> Signup and view all the answers

Where is the thyroid gland primarily located?

<p>Throat (base) (C)</p> Signup and view all the answers

What is the primary outcome of glycolysis?

<p>Production of ATP (D)</p> Signup and view all the answers

Which type of diabetes is characterized by insulin dependence?

<p>Type I Diabetes Mellitus (A)</p> Signup and view all the answers

What happens to glucose levels in the absence of insulin?

<p>They increase significantly (D)</p> Signup and view all the answers

Which condition results from excess glucose spilling into the urine?

<p>Diabetes Mellitus (A)</p> Signup and view all the answers

What is a common symptom associated with diabetes mellitus?

<p>Frequent urination (B)</p> Signup and view all the answers

What characterizes Type II Diabetes Mellitus?

<p>Insulin receptor resistance (A)</p> Signup and view all the answers

How are Type II diabetics typically treated?

<p>Diet and oral medications (B)</p> Signup and view all the answers

Which of the following is NOT a cardinal sign of diabetes mellitus?

<p>Polycythemia (D)</p> Signup and view all the answers

What role does glucagon play in blood glucose regulation?

<p>It acts as an antagonist of insulin to raise blood glucose levels. (B)</p> Signup and view all the answers

Which symptom is NOT considered a cardinal sign of diabetes mellitus?

<p>Hyperactivity (D)</p> Signup and view all the answers

What is the primary risk factor for cardiovascular disease in diabetic patients?

<p>Atherosclerosis (C)</p> Signup and view all the answers

What complication may arise from microangiopathies affecting the nephron?

<p>Chronic kidney disease (D)</p> Signup and view all the answers

Which of the following medications is used to prevent plaque buildup in arteries for diabetic patients?

<p>Statins (D)</p> Signup and view all the answers

What effect does diabetic microangiopathy have on capillary membranes?

<p>Thickening of membranes (B)</p> Signup and view all the answers

What is a common symptom associated with glucosuria in diabetes?

<p>Frequent urination (D)</p> Signup and view all the answers

Which dietary adjustments may help manage cardiovascular complications in diabetic patients?

<p>Reduced salt or increased potassium/magnesium intake (D)</p> Signup and view all the answers

Which hormone synthesized by the hypothalamus is responsible for stimulating the secretion of hormones in the anterior lobe of the pituitary gland?

<p>Releasing Hormone (RH) (C)</p> Signup and view all the answers

What is a characteristic feature of endocrine glands compared to exocrine glands?

<p>They are ductless. (A)</p> Signup and view all the answers

Which organ is primarily affected by insulin according to its targets?

<p>Adipocytes (C)</p> Signup and view all the answers

What condition may result from hyposecretion of FSH or LH?

<p>Sterility (D)</p> Signup and view all the answers

How does the hypothalamus regulate adrenal medullae hormone release?

<p>By controlling sympathetic output (A)</p> Signup and view all the answers

What is the primary function of the hormones released by the anterior lobe of the pituitary gland?

<p>To control the activity of other endocrine organs (D)</p> Signup and view all the answers

Which of the following hormones is synthesized by the hypothalamus as an endocrine organ?

<p>Antidiuretic Hormone (ADH) (C)</p> Signup and view all the answers

What is the main difference between endocrine and exocrine glands?

<p>Endocrine glands do not have ducts, while exocrine glands have ducts. (C)</p> Signup and view all the answers

Flashcards

Steroid hormones

Hormones that are lipid-soluble and can pass through the plasma membrane.

Non-steroid hormones

Hormones that are water-soluble and cannot pass through the plasma membrane, requiring cell surface receptors.

Second messenger system

A mechanism of hormone action where the hormone binds to a receptor on the cell surface, initiating a signaling cascade that involves a second messenger like cAMP.

Negative feedback

A system where the product of a pathway inhibits its own production, maintaining a stable internal environment.

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Hormonal stimulus

The regulation of hormone release by other hormones.

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Humoral stimulus

The regulation of hormone release by changes in blood composition.

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Neural stimulus

The regulation of hormone release by nerve impulses.

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Target cell receptors

Specialized proteins on target cells that bind to specific hormones, initiating cellular responses.

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Thyroxine (T4)

A hormone produced by the thyroid gland that regulates metabolism, growth, and development.

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Calcitonin

A hormone produced by the thyroid gland that helps regulate calcium levels in the blood.

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Goiter

An enlargement of the thyroid gland caused by iodine deficiency.

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Cretinism

A condition characterized by an underactive thyroid gland in childhood, leading to stunted growth and mental development.

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Graves' disease

A condition characterized by an overactive thyroid gland, leading to increased metabolism, weight loss, and other symptoms.

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Parathyroid hormone (PTH)

A hormone produced by the parathyroid glands that helps regulate calcium levels in the blood by increasing them.

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Hypocalcemia

A term referring to a decrease in calcium levels in the blood, which can lead to muscle spasms and convulsions.

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PTH & Calcitonin feedback loop

A negative feedback loop between PTH and calcitonin to regulate blood calcium levels.

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Hormone Specificity

The ability of a hormone to influence only specific cells that have the necessary receptors for that hormone.

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Hormones

The chemical messengers that are secreted by endocrine glands and travel through the bloodstream to target cells.

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Hypothalamic Control over Endocrine Organs

The hypothalamus controls the endocrine glands, primarily the anterior pituitary gland, by releasing specific hormones that either stimulate or inhibit hormone production.

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Pituitary Gland

The pituitary gland is often referred to as the master gland of the endocrine system as it regulates the activity of several other endocrine glands.

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Pancreas and Insulin/Glucagon

The pancreas produces insulin and glucagon, which are key regulators of blood sugar levels. Insulin helps lower blood sugar by promoting glucose uptake into cells, while glucagon promotes the release of sugar from storage, increasing blood sugar.

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What hormones are produced by the anterior pituitary?

The anterior pituitary gland is responsible for producing six key hormones: growth hormone (GH), prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH). These hormones play crucial roles in regulating various bodily functions, including growth, metabolism, and reproduction.

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How does the hypothalamus connect to the anterior pituitary?

The hypothalamus, a brain region, plays a critical role in regulating the anterior pituitary gland's function. It produces releasing and inhibiting hormones that control the synthesis and release of hormones from the anterior pituitary.

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What hormones does the posterior pituitary produce?

The posterior pituitary gland is responsible for secreting two key hormones: antidiuretic hormone (ADH), also known as vasopressin, and oxytocin. While these hormones are produced by the hypothalamus, they are stored and released from the posterior pituitary.

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What is the function of growth hormone (GH)?

The anterior pituitary hormone, growth hormone (GH), plays a vital role in regulating growth, particularly during childhood. It stimulates the growth of bones and muscles. Insufficient GH production can lead to dwarfism, while excessive production can lead to gigantism or acromegaly.

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What is the function of melatonin?

Melatonin, produced by the pineal gland, is a hormone that regulates sleep-wake cycles. Melatonin production is influenced by light, with higher levels produced during darkness and lower levels during daylight.

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What is the pineal gland and its function?

The pineal gland is a small, cone-shaped gland located in the brain. It is responsible for producing the hormone melatonin, which regulates sleep-wake cycles and other physiological processes.

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Compare and contrast the number of hormones produced by the anterior and posterior pituitary.

The anterior pituitary gland produces six major hormones, while the posterior pituitary gland produces only two. Both glands play vital roles in the endocrine system, influencing various physiological functions.

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Explain the relationship between the hypothalamus and the anterior pituitary.

The anterior pituitary, a master endocrine gland, regulates the function of other endocrine glands through the hormones it produces. The hypothalamus controls the release of hormones from the anterior pituitary by releasing its own specific hormones.

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Glycolysis

The breakdown of glucose into pyruvate within cells, generating ATP for energy.

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Genesis

The process of forming something, often through a complex series of steps.

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Lysis

The disintegration or breakdown of a substance into smaller components.

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Diabetes Mellitus

A condition characterized by high blood sugar levels due to the body's inability to produce or use insulin properly.

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Type I Diabetes (IDDM)

Type 1 diabetes, where the body's immune system attacks and destroys insulin-producing cells.

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Type II Diabetes

Type 2 diabetes, where the body's cells become resistant to insulin, leading to high blood sugar.

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Insulin Resistance

The inability of cells to respond to insulin, leading to high blood sugar.

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Cardinal Signs of Diabetes

Frequent urination, excessive thirst, and increased hunger, common symptoms of diabetes.

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Diabetes Mellitus (DM)

A condition characterized by high blood glucose levels due to either the pancreas not producing enough insulin or the body's cells not responding properly to insulin.

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Polyuria

Frequent urination, especially at night, caused by the body trying to flush out excess glucose in the urine.

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Polydipsia

Excessive thirst due to the loss of fluids through frequent urination.

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Polyphagia

Increased hunger despite eating more due to the body's inability to properly use glucose for energy.

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Glucosuria

Presence of abnormally high levels of glucose in the urine, a hallmark of diabetes.

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Angiopathies

A complication of diabetes affecting blood vessels, leading to problems in the kidneys, eyes, and lower limbs.

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Diabetic Macroangiopathy

A type of angiopathy affecting large blood vessels, causing blockages and poor circulation, especially in the legs.

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Diabetic Microangiopathy

A type of angiopathy affecting small blood vessels, causing thickening and abnormal exchange of substances, leading to local tissue damage.

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Study Notes

The Endocrine System

  • The study of hormones and endocrine organs is called endocrinology
  • The endocrine system is a collection of widely scattered glands and specialized cells
  • These cells secrete hormones into the bloodstream
  • Works alongside the nervous system
  • Regulates all aspects of body function
  • Regulates growth, development, coordination, homeostasis, glandular secretion, metabolism, hunger, reproduction, digestion, circadian rhythm, electrolyte balance, moods, emotions, and immune response

Learning Outcomes

  • Describe/define the endocrine system
  • Define hormone action
  • Define signaling cascades/second messenger
  • Identify Major endocrine organs (hypothalamus, pituitary, thyroid, parathyroid, pineal, and pancreatic islets)
  • Provide examples of diseases associated with hormone imbalance
  • Focus on diabetes mellitus

The Chemistry of Hormones

  • Hormones are chemical substances secreted by endocrine cells
  • Travel through the bloodstream affecting other parts of the body
  • Non-steroidal hormones: amino-acid based(proteins, peptides, amines)
    • Bind to receptors and activate G proteins
    • Exert effects through second messengers (e.g., cAMP) altering enzyme activity in target cells
    • Cannot diffuse through plasma membranes as not lipid-soluble
    • Bind to receptors on the outer surface of the plasma membrane
  • Steroid hormones: made from cholesterol
    • Include sex hormones from gonads (ovaries/testes) and hormones from adrenal cortex
    • Diffuse through target cell membranes
    • Bind to receptors in the cytoplasm or nucleus
    • Affect gene activity and protein synthesis directly

Mechanism of Hormone Action

  • Hormones can change plasma membrane permeability.
  • Hormones can activate or inactivate enzymes.
  • Hormones can stimulate or inhibit cell division
  • Hormones can promote or inhibit secretion of a product.
  • Hormones can turn on or turn off transcription of certain genes

Control of Hormone Release

  • Stimulation of endocrine glands occurs through 3 mechanisms
    • Hormonal
    • Humoral
    • Neural
  • Hormonal stimuli involves hormones that stimulate other endocrine glands
  • Humoral stimuli is the change in blood contents stimulating the secretion of hormones
  • Neural stimuli involves nerve impulses stimulating endocrine glands

The Role of Target Cell Receptors

  • For the hormone to affect a target cell, the cell must contain specific receptors
  • Receptors that bind to the hormone to initiate the cellular activity change
  • Only cells possessing receptors will be affected by the hormone

Major Organs and Hormones of the Endocrine System

  • The slide provides a detailed diagram of different organs and highlighting their related hormones

Three Mechanisms of Hypothalamic Control over Endocrine Organs

  • The hypothalamus acts as an endocrine organ, producing hormones ADH and oxytocin.
  • Releases regulatory hormones to control activity of anterior lobe of the pituitary gland
  • Controls sympathetic output to adrenal medulla

Endocrine & Exocrine Glands

  • Endocrine glands are ductless
  • Secrete Hormones into the Bloodstream
  • Exocrine glands have ducts
  • Release secretions into ducts

Insulin and Glucose Issues

  • Hormone secreted by beta cells of pancreas
  • Regulates metabolism of carbohydrates, fats, and proteins
  • Regulates gene expression
  • Only hormone reducing blood glucose by promoting its absorption from blood into cells
  • Low or absent insulin leads to hyperglycaemia, and a shorter lifespan
  • Summary statistics and diagrammatic representation on Blood Glucose Homeostasis

Conditions Associated With Insulin: Diabetes Mellitus

  • Type I: Insulin-dependent Diabetes Mellitus, requiring insulin shots
  • Type II: Non-insulin-dependent Diabetes Mellitus, often treated with special diets or medications to improve insulin sensitivity in target cells

Symptoms of Diabetes

  • Glucosuria
  • Polyuria
  • Polydipsia
  • Polyphagia
  • Angiopathies (affecting vessels supplying kidneys, eyes, and lower limbs)

Diabetic Complications

  • Macroangiopathy (peripheral arterial occlusive disease)
  • Microangiopathy (structural abnormalities of capillary membranes resulting in abnormal exchange and local ischemia)
  • Retinopathy (complication affecting retina)
  • Cardiovascular disease
  • Nephropathy (affecting small vessels of nephron and leading to chronic kidney disease)

Quiz Questions

  • The questions cover various aspects of the endocrine system covering hormones, glands, functions, and associated conditions. Multiple choice answers are provided for each question.

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