Endocrine System Quiz
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Questions and Answers

What percentage of thyroid hormone output does T3 represent?

  • 75%
  • 90%
  • 10% (correct)
  • 50%
  • The thyroid gland is located above the larynx and posterior to the trachea.

    False (B)

    What hormones do follicular cells of the thyroid gland produce?

    Thyroid hormones (T3 and T4)

    The thyroid gland is shaped like a ______.

    <p>butterfly</p> Signup and view all the answers

    Match the thyroid hormones with their respective contributions:

    <p>T3 = 10% of thyroid output, responsible for tissue action T4 = 90% of thyroid output</p> Signup and view all the answers

    Which of the following substances is necessary for the synthesis of thyroid hormones?

    <p>Iodine (A)</p> Signup and view all the answers

    Calcitonin is produced by follicular cells of the thyroid gland.

    <p>False (B)</p> Signup and view all the answers

    What role does the hypothalamus play in the secretion of thyroid hormones?

    <p>Stimulates the secretion of thyroid releasing hormone (TRH)</p> Signup and view all the answers

    What hormones are secreted by the adrenal medulla in response to stress?

    <p>Epinephrine and norepinephrine (B)</p> Signup and view all the answers

    The pancreas functions solely as an endocrine gland.

    <p>False (B)</p> Signup and view all the answers

    What role does glucagon play in blood glucose regulation?

    <p>Increases blood glucose levels</p> Signup and view all the answers

    The main hormone secreted by the pineal gland is __________.

    <p>melatonin</p> Signup and view all the answers

    Match the hormone with its gland:

    <p>Melatonin = Pineal gland Testosterone = Testes Insulin = Pancreas Thymosin = Thymus gland</p> Signup and view all the answers

    Which of the following hormone-secreting cells in the pancreas decreases blood glucose levels?

    <p>Beta cells (A)</p> Signup and view all the answers

    Epinephrine and norepinephrine are released during a non-stressful situation.

    <p>False (B)</p> Signup and view all the answers

    What is the function of calcitonin?

    <p>Lowers blood calcium levels</p> Signup and view all the answers

    What is the primary function of thyroid hormones?

    <p>Increases basal metabolic rate (A)</p> Signup and view all the answers

    Hypothyroidism can lead to high metabolic rates.

    <p>False (B)</p> Signup and view all the answers

    What condition results from an excessive secretion of thyroid hormones?

    <p>Hyperthyroidism</p> Signup and view all the answers

    The major mineralocorticoid produced by the adrenal cortex is _____ .

    <p>aldosterone</p> Signup and view all the answers

    Match the following hormones to their primary functions:

    <p>Cortisol = Glucose formation under stress Calcitonin = Lowers blood calcium levels Parathyroid Hormone = Increases blood calcium levels Aldosterone = Regulates sodium and water reabsorption</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with hyperthyroidism?

    <p>Weight gain (A)</p> Signup and view all the answers

    Calcitonin is secreted by the C cells of the parathyroid glands.

    <p>False (B)</p> Signup and view all the answers

    What is the main effect of hypoparathyroidism?

    <p>Increased nerve excitability</p> Signup and view all the answers

    ___ are the two adrenal glands located one above each kidney.

    <p>Adrenal</p> Signup and view all the answers

    Which of the following conditions is characterized by low blood pressure and dehydration due to a deficiency of adrenal cortex hormones?

    <p>Addison’s disease (B)</p> Signup and view all the answers

    Androgens produced in the adrenal cortex primarily affect men.

    <p>False (B)</p> Signup and view all the answers

    What is the physiological effect of glucocorticoids during stressful situations?

    <p>Increase glucose formation</p> Signup and view all the answers

    Parathyroid hormone is responsible for increasing the level of _____ in the blood.

    <p>calcium</p> Signup and view all the answers

    What stimulates the secretion of Calcitonin?

    <p>High blood calcium levels (D)</p> Signup and view all the answers

    Match the following conditions to their respective hormone imbalances:

    <p>Cushing’s syndrome = Hypersecretion of glucocorticoids Addison’s disease = Hyposecretion of glucocorticoids and aldosterone Hyperthyroidism = Excessive thyroid hormone production Hypothyroidism = Insufficient thyroid hormone production</p> Signup and view all the answers

    Flashcards

    Where is the thyroid gland located?

    The thyroid gland is a butterfly-shaped organ located below the larynx and in front of the trachea. It has two lobes connected by a bridge-like isthmus.

    What are the structures within the thyroid gland?

    The thyroid gland is made up of tiny structures called thyroid follicles. The walls of these follicles contain two types of cells: follicular cells and parafollicular cells.

    What are the functions of the cells within the thyroid follicles?

    Follicular cells are responsible for producing thyroid hormones, which regulate metabolism. Parafollicular cells produce calcitonin, a hormone that helps regulate calcium levels in the blood.

    How are thyroid hormones made and stored?

    Thyroid hormones are synthesized from iodine and tyrosine. They are stored within the thyroid follicles as colloid and can sustain the body's needs for 1-3 months.

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    How are thyroid hormones transported in the body?

    Thyroid hormones are transported in the blood by plasma proteins.

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    What triggers the release of TRH?

    Low blood levels of thyroid hormones or a low metabolic rate trigger the hypothalamus to release thyroid-releasing hormone (TRH).

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    What does TRH do?

    TRH stimulates the anterior pituitary gland to release thyroid-stimulating hormone (TSH).

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    What does TSH do?

    TSH stimulates the thyroid follicular cells to produce and release thyroid hormones. It also promotes the growth of these cells.

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    Adrenal Medulla Hormones

    The adrenal medulla, an inner part of the adrenal gland, secretes two hormones - epinephrine (adrenaline) and norepinephrine. These hormones have effects similar to the sympathetic nervous system, essentially preparing the body for a 'fight or flight' response.

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    Epinephrine (adrenaline)

    Epinephrine, also known as adrenaline, is a hormone secreted by the adrenal medulla in response to stress. It plays a critical role in the fight-or-flight response, increasing heart rate, blood pressure, and blood sugar levels.

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    The Pancreas

    The pancreas is a gland located behind the stomach. It functions as both an endocrine and exocrine gland.

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    Pancreatic Islets

    The pancreas contains clusters of hormone-secreting cells called pancreatic islets (islets of Langerhans). These islets contain alpha cells(A) and beta cells (B).

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    Alpha Cells and Glucagon

    Alpha cells in the pancreas secrete glucagon, a hormone that increases blood glucose levels by promoting the breakdown of glycogen into glucose.

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    Beta Cells and Insulin

    Beta cells in the pancreas secrete insulin, a hormone that decreases blood glucose levels by promoting the uptake of glucose from the blood into cells.

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    Ovary Hormones

    The ovaries, female reproductive organs, produce three main hormones: estrogens, progesterone, and inhibin. These hormones regulate the menstrual cycle, maintain pregnancy, prepare the mammary glands for lactation, and establish and maintain female secondary sex characteristics.

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    Testes Hormone

    The testes, the male reproductive organs, produce testosterone, an androgen hormone. Testosterone plays a crucial role in regulating sperm production, promoting development, and maintaining male secondary sex characteristics.

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    Hyperthyroidism

    A condition where the thyroid gland is enlarged and produces excessive thyroid hormones leading to a high metabolic rate, hyperactivity, insomnia, nervousness, irritability, and chronic fatigue.

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    Hypothyroidism

    A state of deficiency or lack of thyroid hormones. In infants, it can cause cretinism, a condition characterized by mental retardation and abnormal skeletal features. In adults, it can lead to myxedema, with symptoms like slow heart rate, low body temperature, sensitivity to cold, dry hair and skin, muscular weakness, general lethargy, and weight gain.

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    Calcitonin

    A hormone secreted by the parafollicular cells or C cells in the thyroid gland. It inhibits osteoclast activity, lowering the blood level of calcium. Its secretion is controlled by calcium levels in the blood.

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    Parathyroid glands

    Small glands embedded on the posterior surfaces of the lateral lobes of the thyroid gland. Each thyroid lobe has two parathyroid glands attached to it.

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    Parathyroid hormone (PTH)

    The major hormone produced by the parathyroid glands, responsible for regulating calcium, magnesium, and phosphate levels in the blood. It increases osteoclast activity, promotes reabsorption of calcium from the urine, and inhibits phosphate reabsorption, leading to more phosphate excretion.

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    Hypoparathyroidism

    A condition caused by insufficient secretion of parathyroid hormone (PTH), leading to low blood calcium levels and increased nerve excitability, resulting in spontaneous muscle contractions.

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    Hyperparathyroidism

    A condition caused by excessive secretion of parathyroid hormone (PTH) due to a tumor in the thyroid gland. It increases osteoclast activity, removes calcium from the bones, and raises blood calcium levels. Excess calcium can cause kidney stones.

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    Adrenal glands

    Two glands, one superior to each kidney, consisting of an adrenal cortex (outer) and adrenal medulla (inner).

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    Adrenal cortex

    The outer layer of the adrenal gland, subdivided into three zones: zona glomerulosa, zona fasciculata, and zona reticularis, each producing different steroid hormones.

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    Mineralocorticoids

    Hormones produced by the zona glomerulosa of the adrenal cortex. The major mineralocorticoid is aldosterone, which regulates blood pressure and volume by increasing sodium and water reabsorption, decreasing potassium reabsorption, and promoting hydrogen ion excretion.

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    Glucocorticoids

    Hormones produced by the zona fasciculata of the adrenal cortex. The primary glucocorticoid is cortisol, which regulates glucose metabolism, increases protein breakdown, stimulates triglyceride breakdown, has anti-inflammatory effects, and suppresses immune response.

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    Androgens

    Hormones produced by the zona reticularis of the adrenal cortex. They have masculinizing sex hormone effects but have minimal effects in men, playing a role in libido in women.

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    Cushing's syndrome

    A condition caused by hypersecretion of hormones from the adrenal cortex, characterized by hyperglycemia, puffiness or edema, and loss of potassium ions.

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    Addison's disease

    A condition caused by hyposecretion of glucocorticoids and aldosterone from the adrenal cortex, leading to hypoglycemia, sodium loss, low blood pressure, dehydration, and muscle weakness.

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    Study Notes

    Endocrine System Overview

    • The endocrine system is a complex network of glands that release hormones into the bloodstream to regulate various bodily functions.
    • Visual aids (images) show various thyroid conditions and endocrine glands.
    • Learning objectives are to describe the locations, hormones, and functions of specific endocrine glands.

    Thyroid Gland

    • The butterfly-shaped thyroid gland is located below the larynx and in front of the trachea.
    • It has two lobes connected by an isthmus.
    • The thyroid gland is highly vascular.
    • The thyroid gland consists of follicles, with follicular cells producing thyroid hormones. Parafollicular cells (C cells) produce calcitonin.

    Thyroid Hormones

    • The thyroid gland produces two types of hormones: T3 (triiodothyronine) and T4 (thyroxine or tetraiodothyronine).
    • T4 constitutes 90% of thyroid output.
    • T3 is responsible for the majority of the thyroid hormone's tissue actions.
    • Thyroid hormones are synthesized from iodine and tyrosine.
    • Iodine sources include sea fish, bread, vegetables, and milk.

    Thyroid Hormone Secretion

    • Low thyroid hormone levels or low metabolic rate trigger the hypothalamus to release thyroid-releasing hormone (TRH).
    • TRH travels to the anterior pituitary, which then releases thyroid-stimulating hormone (TSH).
    • TSH stimulates the thyroid follicular cells, which release T3 and T4 hormones into the blood, maintaining normal metabolic rates.
    • Elevated T3 and T4 levels inhibit further TRH and TSH release (negative feedback).

    Thyroid Hormone Function

    • Thyroid hormones increase the basal metabolic rate (BMR).
    • They contribute to body temperature maintenance.
    • They stimulate protein synthesis.
    • They increase the use of glucose and fatty acids for ATP production.
    • Along with growth hormone and insulin, they stimulate body growth in nervous and skeletal systems.

    Clinical Applications (Hyperthyroidism)

    • Hyperthyroidism involves an enlarged thyroid gland and excessive thyroid hormone production.
    • It frequently leads to toxic goiter and Graves' disease.
    • Symptoms include elevated metabolic rate, hyperactivity, insomnia, nervousness, irritability, and chronic fatigue.

    Clinical Applications (Hypothyroidism)

    • Hypothyroidism is a deficiency or lack of thyroid hormones.
    • In infants, it can cause cretinism, leading to mental retardation and skeletal abnormalities.
    • In adults, it can lead to myxedema, presenting as symptoms like low heart rate, low body temperature, sensitivity to cold, dry skin and hair, muscular weakness, lethargy, and weight gain.

    Calcitonin

    • Parafollicular cells (C cells) in the thyroid gland secrete calcitonin.
    • Calcitonin inhibits osteoclast activity, lowering blood calcium levels.
    • Blood calcium levels regulate calcitonin secretion.

    Parathyroid Glands

    • These glands are embedded in the posterior surfaces of the thyroid lobes, two to each lobe.
    • Parathyroid glands contain chief cells, which produce parathyroid hormone (PTH).

    Parathyroid Hormone (PTH) Function

    • PTH is a major regulator of blood calcium, magnesium, and phosphate levels.
    • It increases osteoclast activity, releasing calcium ions from bone matrix and regulating phosphate reabsorption rate in urine.
    • PTH promotes calcitriol formation, stimulating Ca2+, Mg2+, and phosphate absorption from the gastrointestinal tract.
    • Hypoparathyroidism and hyperparathyroidism are disorders related to PTH secretion imbalances.

    Adrenal Glands

    • Paired adrenal glands, superior to each kidney, consist of an outer cortex and inner medulla.
    • The adrenal cortex produces steroid hormones, all derived from cholesterol.
    • Zones within the adrenal cortex secrete specific groups of hormones: mineralocorticoids, glucocorticoids, and androgens.

    Mineralocorticoids

    • Mineralocorticoids, primarily aldosterone, are produced in the zona glomerulosa of the adrenal cortex.
    • They regulate sodium and potassium levels in response to dehydration.
    • They increase sodium reabsorption and water retention.
    • They decrease potassium reabsorption and promote potassium excretion in the urine, helping control blood pressure.
    • The renin-angiotensin-aldosterone pathway controls aldosterone secretion.

    Glucocorticoids

    • Glucocorticoids, mainly cortisol, are produced in the zona fasciculata of the adrenal cortex.
    • They are vital for glucose metabolism in stressful situations.
    • Glucocorticoids promote glucose formation, stimulate protein breakdown, increase fat breakdown, and have anti-inflammatory effects.
    • ACTH (adrenocorticotropic hormone) regulates cortisol secretion, working through a feedback loop.

    Adrenal Androgens

    • Adrenal androgens are produced by the zona reticularis, impacting libido in females, with minimal effects in males.

    Clinical Applications (Adrenal Glands)

    • Cushing's syndrome is characterized by excess glucocorticoid secretion, leading to hyperglycemia, edema (swelling), and potassium loss.
    • Addison's disease results in insufficient glucocorticoid and mineralocorticoid secretion. Typical symptoms include hypoglycemia, sodium loss, low blood pressure (BP), dehydration, and muscle weakness.

    Adrenal Medulla

    • The adrenal medulla secretes epinephrine (adrenaline) and norepinephrine (noradrenaline).
    • These hormones create responses mimicking the sympathetic nervous system.
    • Secretion is triggered by stressful situations (fight-or-flight response).

    Pancreas

    • The pancreas is both an endocrine and exocrine gland.
    • It is located behind and slightly below the stomach.
    • The pancreas contains pancreatic islets (islets of Langerhans), which consist of alpha (α) and beta (β) cells.

    Pancreatic Hormones

    • Alpha cells secrete glucagon, increasing blood glucose levels.
    • Beta cells secrete insulin, decreasing blood glucose levels.

    Gonadal Hormones

    • Ovaries produce estrogens, progesterone, inhibin, and relaxin, regulating the menstrual cycle, maintaining pregnancy, and preparing mammary glands for lactation, establishing and maintaining secondary sex characteristics in females.
    • Testes produce testosterone (an androgen), regulating sperm production and developing and maintaining secondary sex characteristics in males.

    Pineal Gland

    • The pineal gland, located near the roof of the third ventricle of the brain, secretes melatonin.
    • Melatonin regulates the biological clock, impacting seasonal and daily cycles.

    Thymus Gland

    • The thymus gland secretes thymosin, promoting T-cell proliferation and maturation.
    • T cells are crucial to the immune response, destroying microorganisms and foreign substances.

    Recap/Quiz (multiple topics)

    • Presented in a question-and-answer format, summarizing key facts about various endocrine functions and related diseases like goiter, Graves' disease, cretinism, myxedema, Cushing's syndrome, and Addison's disease.

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    Endocrine System Notes PDF

    Description

    Test your knowledge on the endocrine system, focusing on hormones produced by the thyroid, adrenal medulla, and pancreas. This quiz covers hormone functions and the relationships between different glands in the body. Challenge yourself to match hormones with their respective glands and understand their roles in regulating various physiological processes.

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