Podcast
Questions and Answers
Which of the following substances can directly stimulate hormone secretion?
Which of the following substances can directly stimulate hormone secretion?
- Neurotransmitters
- Circulating Hormones
- Metabolites
- All of the above (correct)
Which layer of the adrenal cortex is responsible for secreting aldosterone?
Which layer of the adrenal cortex is responsible for secreting aldosterone?
- Medulla
- Reticularis
- Fasciculata
- Glomerulosa (correct)
Which hormone is primarily secreted in an episodic pattern?
Which hormone is primarily secreted in an episodic pattern?
- Cortisol
- Growth Hormone (correct)
- Thyroid Hormone
- Insulin
What is the primary function of the hypothalamus in relation to hormone secretion?
What is the primary function of the hypothalamus in relation to hormone secretion?
Which hormone exhibits a circadian secretion pattern, peaking in the morning?
Which hormone exhibits a circadian secretion pattern, peaking in the morning?
Which of the following is NOT a typical factor that influences hormone secretion patterns?
Which of the following is NOT a typical factor that influences hormone secretion patterns?
What is the term for hormone secretion that occurs locally within a gland to regulate neighboring cells?
What is the term for hormone secretion that occurs locally within a gland to regulate neighboring cells?
The adrenal gland is located on top of which organ?
The adrenal gland is located on top of which organ?
What type of feedback mechanism is responsible for the regulation of growth hormone (GH) secretion?
What type of feedback mechanism is responsible for the regulation of growth hormone (GH) secretion?
Which of the following correctly describes the role of the hypothalamus in the HPT axis?
Which of the following correctly describes the role of the hypothalamus in the HPT axis?
Which anterior pituitary hormone is responsible for stimulating the adrenal gland to produce cortisol?
Which anterior pituitary hormone is responsible for stimulating the adrenal gland to produce cortisol?
Which of the following is NOT a direct effect of growth hormone (GH)?
Which of the following is NOT a direct effect of growth hormone (GH)?
Which of the following accurately describes the role of the pituitary gland in the endocrine system?
Which of the following accurately describes the role of the pituitary gland in the endocrine system?
Which hormone is responsible for stimulating the release of both LH (luteinizing hormone) and FSH (follicle-stimulating hormone) from the anterior pituitary?
Which hormone is responsible for stimulating the release of both LH (luteinizing hormone) and FSH (follicle-stimulating hormone) from the anterior pituitary?
What is the primary difference between the long loop and short loop feedback mechanisms in hormone regulation?
What is the primary difference between the long loop and short loop feedback mechanisms in hormone regulation?
Which of the following is an example of positive feedback in hormone regulation?
Which of the following is an example of positive feedback in hormone regulation?
Which of the following is a characteristic of a primary endocrine disorder?
Which of the following is a characteristic of a primary endocrine disorder?
What is the primary function of the hypothalamus in the endocrine system?
What is the primary function of the hypothalamus in the endocrine system?
Flashcards
Hormone secretion signals
Hormone secretion signals
Signals that stimulate hormone secretion include neurotransmitters, hormones, metabolites, and paracrine factors.
Neurotransmitters
Neurotransmitters
Chemicals that transmit signals across a synapse, stimulating hormone secretion.
Neural hormones
Neural hormones
Hormones released by the hypothalamus that stimulate the pituitary gland.
Circulating hormones
Circulating hormones
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Paracrine secretion
Paracrine secretion
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Adrenal cortex layers
Adrenal cortex layers
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Circadian secretion
Circadian secretion
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Episodic secretion
Episodic secretion
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Hypothalamus function
Hypothalamus function
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HPG Axis
HPG Axis
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HPA Axis
HPA Axis
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HPT Axis
HPT Axis
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Negative Feedback Regulation
Negative Feedback Regulation
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Positive Feedback Regulation
Positive Feedback Regulation
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Hypo-secretion
Hypo-secretion
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Hyper-secretion
Hyper-secretion
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Hypo-responsiveness
Hypo-responsiveness
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Endocrine disorders
Endocrine disorders
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Study Notes
Hormone Secretion Stimuli
- Various signals stimulate hormone secretion, including:
- Neurotransmitters: Examples like glutamate, GABA, dopamine, epinephrine, norepinephrine, histamine, serotonin
- Neural Hormones: Hypothalamic hormones stimulating the pituitary
- Circulating Hormones: Hormones from other glands (e.g., gonads responding to LH/FSH; thyroid responding to TSH)
- Paracrine Hormones: Local regulation within a gland (e.g., testosterone stimulating sperm production)
- Metabolites: Substances like glucose, amino acids, calcium influencing hormone release (e.g., glucose/amino acids stimulating pancreas; calcium regulating PTH)
Adrenal Gland Structure and Function
- Located atop the kidneys, with two parts:
- Medulla: Inner part
- Cortex: Outer part, further divided into:
- Glomerulosa (orange): Stimulated by angiotensin II to secrete aldosterone
- Fasciculata (blue): Stimulated by ACTH to secrete cortisol
- Reticularis (green): Stimulated by ACTH to secrete androgens
Hormone Secretion Patterns
- Circadian Secretion: Daily cycle, e.g., cortisol peaking in the morning, helping prepare the body.
- Episodic Secretion: Bursts of varying duration/frequency; common in hypothalamic and pituitary hormones. Example: Growth hormone is secreted episodically, primarily at night during sleep.
The Hypothalamus
- Crucial integration center, receiving input from various sources (thalamus, limbic system, sensory systems, visceral system; hormonal and environmental stimuli like light, temperature, sleep, mood, activity, and glucose).
- Processes input and controls pituitary gland to maintain homeostasis.
- Acts as central control point for the endocrine system.
Hypothalamus-Pituitary Endocrine Axis
- The hypothalamus controls the pituitary gland, which in turn regulates target organs.
- Example axes:
- HPG (Hypothalamus-Pituitary-Gonads): GnRH → LH/FSH → Gonadal hormones (estrogen, androgen, progesterone)
- HPA (Hypothalamus-Pituitary-Adrenal): CRH → ACTH → Cortisol/Aldosterone
- HPT (Hypothalamus-Pituitary-Thyroid): TRH → TSH → T3/T4
- Other hypothalamic hormones:
- GHRH: Stimulates growth hormone (GH), influencing metabolism and IGF production.
- Somatostatin: Inhibits GH and TSH secretion.
- Dopamine and TRH: Stimulate prolactin production.
Anterior Pituitary Hormones
- Hormone | Cell Type | Structure
- ---|---|---
- ACTH | Corticotroph | 39 amino acids
- TSH | Thyrotroph | α subunit shared with LH/FSH; unique β subunit
- LH | Gonadotroph | α subunit shared with TSH/FSH; unique β subunit
- FSH | Gonadotroph | α subunit shared with TSH/LH; unique β subunit
Regulation of Hormone Secretion
- Negative Feedback: Target organ hormones inhibit pituitary/hypothalamic hormones (e.g., long, short, ultra-short loops).
- Positive Feedback: Target organ hormones stimulate pituitary/hypothalamic hormones (e.g., estrogen stimulating follicle maturation).
- Product Regulation: Hormone products (e.g., sodium, calcium, glucose) influence hormone secretion.
Endocrine Disorders
- Hypo-secretion: Low hormone levels, due to target gland, pituitary, or hypothalamic dysfunction.
- Hyper-secretion: High hormone levels, due to target gland, pituitary, or hypothalamic hyperactivity.
- Hypo-responsiveness: Reduced hormone response (e.g., type 2 diabetes).
- Hyper-responsiveness: Enhanced hormone response (e.g., overgrowth).
Example: Cortisol
- Secretion governed by the HPA axis
- Peaks in the morning, preparing the body.
- Suppression by long-term exogenous cortisol medication suppresses the HPA axis and ACTH.
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